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  • 1
    Electronic Resource
    Electronic Resource
    Collagen distribution in human membranous glomerulonephritis (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 14-21 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Glomerular extracellular matrix   ;   Type IV collagen chains   ;   Fibrillar collagen   ;   Immunofluorescence   ;   Immunogold electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In membranous glomerulonephritis (MGN), thickening of the glomerular basement membrane (GBM) is partly due to the accumulation of basement membrane material between and around immune deposits located on the epithelial aspect of the GBM. We investigated the distribution of type IV collagen chains (α1/α2, α3, α4, α5, α6) and of types I, III, V, and VI collagen in the glomeruli from 16 patients, by indirect immunofluorescence in 13 and the high-resolution immunogold technique in 6. No changes were detected in stage I MGN. The spiky projections of the GBM in stage II MGN and the basement membrane layers encircling immune deposits in stage III contained the α3, α4, and α5 chains of type IV collagen. In contrast, the α1/α2 chains of type IV, as well as type VI collagen accumulated in the subendothelial aspect of the GBM. No significant staining for types I, III, and V collagens or for the α6 chain of type IV collagen was detected. The results show that, as in the normal glomeruli, the different chains of type IV collagen are not co-distributed in the glomerular extracellular matrix in MGN. They also indicate that type IV collagen chains and type VI collagen play an important role in the thickening of the GBM in human MGN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00863429
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Alport syndrome, basement membranes and collagen (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 523-532 
    Details
    ISSN: 1432-198X
    Keywords: Alport syndrome ; Hereditary nephritis ; Basement membranes ; Collagen IV ; X-linkage ; Post-transplant anti-glomerular basement membrane nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alport syndrome, an inherited disorder of the kidney, eye and ear, has fascinated nephrologists, pathologists, and geneticists for nearly a century. With the recent application of molecular biochemical and genetic techniques, this mysterious disease has begun to yield some of its secrets. Alport syndrome can now be viewed as a generalized disorder of basement membranes that appears to result from mutations in an X-chromosome-encoded basement membrane collagen chain. This chain, along with two other novel collagen chains, is absent from Alport basement membranes, in contrast to the classical chains of collagen IV. Phenotypic heterogeneity in Alport syndrome probably arises from allelic mutations at a single genetic locus. The phenomenon of post-transplant anti-glomerular basement membrane nephritis may be a manifestation of specific mutations at the Alport locus that prevent synthesis of the gene's protein product and the establishment of immunological tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869840
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Collagen distribution in human membranous glomerulonephritis (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 14-21 
    Details
    ISSN: 1432-198X
    Keywords: Glomerular extracellular matrix ; Type IV collagen chains ; Fibrillar collagen ; Immunofluorescence ; Immunogold electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In membranous glomerulonephritis (MGN), thickening of the glomerular basement membrane (GBM) is partly due to the accumulation of basement membrane material between and around immune deposits located on the epithelial aspect of the GBM. We investigated the distribution of type IV collagen chains (α1/α2, α3, α4, α5, α6) and of types I, III, V, and VI collagen in the glomeruli from 16 patients, by indirect immunofluorescence in 13 and the high-resolution immunogold technique in 6. No changes were detected in stage I MGN. The spiky projections of the GBM in stage II MGN and the basement membrane layers encircling immune deposits in stage III contained the α3, α4, and α5 chains of type IV collagen. In contrast, the α1/α2 chains of type IV, as well as type VI collagen accumulated in the subendothelial aspect of the GBM. No significant staining for types I, III, and V collagens or for the α6 chain of type IV collagen was detected. The results show that, as in the normal glomeruli, the different chains of type IV collagen are not co-distributed in the glomerular extracellular matrix in MGN. They also indicate that type IV collagen chains and type VI collagen play an important role in the thickening of the GBM in human MGN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00863429
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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