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  • 1
    Electronic Resource
    Electronic Resource
    Ein Beitrag zur Frage über die Verbreitung der Tuberculose unter den Marinemannschaften des Kronstädter Hafens (1897)
    Springer
    Medical microbiology and immunology 24 (1897), S. 351-372 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02220475
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High Cell Density Fermentation of Recombinant Escherichia coli with Computer-Controlled Optimal Growth Rate (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 646 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb18592.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Laboratory-scale permeabilization of Escherichia coli cells for recovery of a small recombinant protein – Staphylokinase (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 35-38 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The recovery of recombinant proteins includes a purification process that has to be compressed to a minimum of steps in order to get high yields with a low cost expenditure. A selective liberation of recombinant proteins by cell permeabilization leads to both a high product purity just in the beginning of the recovery process and to a simplification of the cell residue separation compared to the mechanical cell disruption. In case of the purification of the bacterial plasminogen activator Staphylokinase from E. coli cells, yields of 82% with a purity of 46% were attained by utilization of permeabilization by biomass freezing, resuspension in a Tris/EDTA-buffer and following micro-diafiltration. A recovery process without interruption (freezing) is possible due to the addition of guanidine-HCl and Triton X100 to the buffer. These methods were developed on a laboratory-scale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008954
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Model aided design of repeated fed-batch penicillin fermentation (1987)
    Springer
    Bioprocess and biosystems engineering 2 (1987), S. 169-173 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Structured models of antibiotic fermentation that quantify maturation and aging of product forming biomass are fitted to experimental data. Conditions of superiority of repeated fed batch cultivation are characterized on the basis of a performance criterion that includes penicillin productivity and costs of operation. Emphasis is placed on the relevance of such research to the model aided design of optimal cyclic operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387324
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Growth of Escherichia coli in phosphate limited cultures : Measurements and modelling (1979)
    Springer
    Biotechnology letters 1 (1979), S. 377-382 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The batch cultivation ofEscherichia coli limited by inorganic phosphate shows an exponential growth phase followed by a linear phase when the phosphate in the medium is exhausted. Data analysis and modelling of batch cultivation with different initial concentrations of the limiting factor give information about an exchangeable phosphate store, with RNA as the main component, and a non-exchangeable store.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01386703
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  • 6
    Electronic Resource
    Electronic Resource
    Definition und Bestimmung des Verstärkungsfaktors in zellulären Regelsystemen (1968)
    Springer
    Radiation and environmental biophysics 5 (1968), S. 24-31 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Description / Table of Contents: Zusammenfassung Nach einer Definition der Verstärkung in biologischen Systemen wird am Beispiel desβ-Galaktosidase-Systems inEscherichia coli gezeigt, daß der aus der Regelungstechnik übernommene Begriff sinnvoll eingeführt werden kann. Es erweist sich, daß man im Verstärkungsfaktor eine weitere Größe zur Charakterisierung desβ-Galaktosidase-Systems zur Verfügung hat, die spezifische Aussagen über das dynamische Verhalten des Systems ermöglicht. Die näherungsweise Bestimmung des Verstärkungsfaktors aus experimentellen Daten läßt Oszillationen des Verstärkungsfaktors erkennen.
    Notes: Summary It is shown that the concept of amplification is meaningful in cellular control systems. The coefficient of amplification (gain) is defined for theβ-galactosidase system inEschericha coli. The amplification in theβ-galactosidase system is evaluated by an approximation method. In an example the coefficient of amplification is determined from experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01388129
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  • 7
    Electronic Resource
    Electronic Resource
    Computer controlled transient state in a fed batch culture (1980)
    Springer
    Biotechnology letters 2 (1980), S. 315-320 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A controlled shift down of the specific growth rate in a fed batch culture is proposed for microbial product formation processes. The growth kinetics depend on three preset parameters: initial biomass concentration, initial specific growth rate, and the transient constant (time derivative of the specific growth rate). An experimental example is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172644
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Instabilities of product formation in a fed-batch culture of Penicillium chrysogenum (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 1563-1572 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: By investigation of a model of benzylpenicillin fermentation it was demonstrated that high fermentation productivity is connected with low stability. The increasing instability is not the result of external disturbances but of peculiarities inherent to the system. The main process variables and the essential parameters were selected by analysis of data obtained from fermentation runs in a pilot plant. By simulation on an analog computer it was shown that the proposed model gives a sufficient description of the kinetic behavior of the fermentation runs. By varying the initial conditions it was possible to obtain two types of fermentation runs. One type is distinguished by a high productivity connected with low initial concentrations of sucrose. An increase of the initial sucrose concentration also causes an increase of productivity. When a certain value of this concentration is exceeded a changeover to a faster growth of biomass takes place combined with the breakdown of productivity. The same phenomenon occurs at a defined initial concentration of sucrose if a disturbance of oxygen transfer rate takes place. Whether the culture stays in the one or in the other state after the disturbance has passed depends on the duration, the strength, and the beginning of the disturbance. In the pilot plant similar behavior can be observed. The sensitivity of fermentation processes to disturbances increases with the increase of productivity.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260230715
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Optimal substrate profile for antibiotic fermentations (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 2771-2777 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The optimal substrate profile is calculated by Pontryagin's maximum principle for a simplified mathematical model of microbial growth and product formation. This model is fitted to experimental data of turimycin fermentation. Sub optimal control is studied for comparison.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260231211
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis and simulation of complex interactions during dynamic microfiltration of Escherichia coli suspensions (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 59 (1998), S. 189-202 
    Details
    ISSN: 0006-3592
    Keywords: artificial neural network (ANN) ; microfiltration ; cell harvesting ; membrane fouling ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Microfiltration is an important unit operation in downstream processing. However, due to the influence of membrane fouling, prediction of the filtration performance for biological suspensions is difficult. This paper describes a modeling approach that allows a comprehensive description of filtration performance. On the basis of experimental data and linguistic information, a specific artificial neural network was developed that predicts the process behavior within a certain range of parameters. This approach allows us to analyze influences of fermentation on filtration. By using extensive simulations, the interactions of 17 parameters were examined and the fouling causes determined. The model was developed for cell harvesting of Escherichia coli through a shear-enhanced module. The method can be applied to any cross-flow filtration process. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59:189-202, 1998.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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