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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 7 (1974), S. 277-283 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0509
    Keywords: Mucus ; Mucinous cancer ; CT ; US ; Duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Although duct ectasia due to mucus-producing pancreatic cancer has been well known, its occurrence in other organs has not been reported. We have studied the pathologic basis of the radiologic features in cases of mucus-producing cancer with intraductal extension. Methods We conducted a comparative study of detailed various radiographic images and pathological findings in 10 cases of mucus-producing cancers (four of mucusproducing pancreatic cancer, two of mucinous gastric cancer with diffuse lymphangitic liver metastasis, and four cases of bronchoalveolar cell carcinoma with cyst or cavity). Results When mucus-producing cancer occurs in a secretory duct or extends into lymphatic ducts, the normal duct is dilated due to the mucus and increased internal pressure, leading to the formation of a cyst and cavity. Because of having the liquid property of mucus floating cancer cells, the lesion can easily progress to continuous ducts as well as regionally. Conclusions In cases of mucus-producing cancer with extension into the ductal structure not only in the pancreas but also in the lung and liver, continuous duct ectasis and cysts filled with mucus or cavities of all sizes made by the nature of the mucus may be detected by CT and US.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0509
    Keywords: Pancreas, cysts ; Rupture ; Panniculitis ; Duodenum ; CT studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a patient with transient periduodenal panniculitis due to spontaneous rupture of a pancreatic pseudocyst into the duodenum. He developed sudden onset of severe epigastric and back pain with jaundice, mimicking the symptoms of acute pancreatitis. However, the serum and urinary amylase levels did not increase. CT scans showed disappearance of his pseudocyst and periduodenal panniculitis without any evidence of acute pancreatitis. The CT findings of periduodenal panniculitis and his symptoms both improved within 3 weeks. A duodenal fistula leading to the remnant pseudocyst and narrowing of the periduodenal portion of the common bile duct were demonstrated by endoscopic retrograde cholangiopancreatography.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 59 (1983), S. 79-87 
    ISSN: 1432-0533
    Keywords: Pick's disease ; Panencephalic type ; Pick bodies ; Subcortical gliosis ; Chronic trichloroethylene intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A man aged 64, with a history of chronic trichloroethylene intoxication, presented early headache, impairment of memory, and “stehende Redensarten”, later on mental deterioration with muteness and oral tendency. He died of bronchopneumonia. The brain was studied by light and electron microscopy. Numerous inflated cells, intraneuronal argentophil Pick bodies and central chromatolysis of neurons were found throughout the cerebral cortex. Widespread diffuse fibrillary gliosis was the finding bearing a striking resemblance to “progressive subcortical gliosis”. Severe loss of nerve cells was observed in the temporal lobe (except the posterior of T1) and moderate or mild loss in the gyrus rectus, insula, gyrus cinguli, and partial areas of the frontal, parietal, and occipital lobes. By electron microscopy, the argentophil Pick bodies consisted of a conglomeration of randomly arranged short 100–150Å filaments, ribosomes, vesicles mitochondria, and scanty paired helical filaments. The present case was considered to represent a rare case of Pick's disease of the temporo-fronto-parieto-occipital type or panencephalic type.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0533
    Keywords: Granulovacuolar degeneration ; Hippocampus ; Topography ; Aging ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's disease (PD; 5 cases) and atypical dementia [5 cases; non-Alzheimer, non-Pick dementia with Fahr's syndrome (NANPDF)] were investigated. GVD was rarely found in control cases below the age of 60 years. In elderly normal brains, the statistically most representative ranking order of predilection for GVD (in decreasing severity) was: in the 60 s, CA1〉prosubiculum 〉CA2 (no GVD was found in the CA3 and CA4); in the 70 s, CA1〉prosubiculum 〉CA2 〉CA3〉CA4; in the 80 s, CA1〉prosubiculum 〉CA2〉CA3〉CA4; in the 90s, CA1〉prosubiculum 〉CA2〉CA3〉CA4. In the brains of demented patients, the rank order for GVD was: for AD, CA1 〉CA2〉CA3〉 prosubiculum 〉CA4; for MID, CA1 〉 prosubiculum 〉CA2〉CA3〉CA4; for PD, CA1 〉CA2〉CA3〉 prosubiculum 〉CA4; and for atypical dementia (NANPDF), CA1〉CA2〉 prosubiculum 〉CA3〉CA4. The similarity of the predilection to ranking order was noted both in normal aged subjects and in MID as well as both in AD and in PD. The qualitative investigation disclosed that the affected neurons with GVD in the cases of AD were found in all the examined areas outside the hippocampus (gyrus praecentralis, temporal and occipital cortex, globus pallidus, amygdaloid nuclei, mammillary bodies, medial thalamic nuclei, red nuclei, nuclei basalis of Meynert, dentate nuclei and inferior olivary nuclei) and, contrary to the results in AD, there were no affected neurons with GVD in the cases of MID. The occurrence and distribution of GVD in demented patients were different in these respective disorders.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 64 (1984), S. 12-14 
    ISSN: 1432-0533
    Keywords: Burkitt-type lymphoma ; Central nervous system (CNS)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A primary Burkitt-type lymphoma of the central nervous system (CNS) is presented. The right temporoparietal tumor in a woman of 55 was diagnosed histologically as a Burkitt-type lymphoma. Primary Burkitt-type lymphoma of the CNS is extremely rare and has been reported previously only four times. This is the first case reported in Eastern Asia.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The growth cycle and related vertical distribution of the thecosomatous pteropod Spiratella (“Limacina”) helicina (Phipps) were studied. S. helicina has a life cycle of approximately 1.5 to 2 years in the central Arctic Ocean (Canada Basin). It spawns mainly during the spring to summer period, and on a small scale during the winter. The young double their sizes during the winter months of October to May, slow down in growth until late summer, and attain maximum size in early winter. The oldest disappear by late March. Gonadal tissue was first seen in young pteropods of 0.7 mm diameter, the predominant size from February to April. S. helicina 0.8 mm in diameter, the size predominant from May through July, are mature and hermaphroditic. Growth during the winter months suggests that particulate organic matter is available during this period to these obligate ciliary feeders. Vertical distribution is size and season-dependent. The youngest specimens collected (0.2 to 0.4 mm) were found concentrated in the first 50 m. The larger sizes dispersed during the summer months, and tended to concentrate in the top 150 m during the rest of the year. They aggregated in the top 50 m from late winter through early spring, and fall through early winter; then concentrated in the 100 to 50 m level until the end of winter. Numerous environmental factors seem to be involved in determining the vertical distribution of the species in the central Arctic Ocean.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Marine biology 73 (1983), S. 221-226 
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Hematocrit and hemoglobin concentration of yellowtail blood elevated more than 30% during severe hypoxia for 35 or 40 min. About 40% of the hematocrit elevation is considered to have been caused by erythrocyte supply from the spleen, and about 60% by hemoconcentration due to water shift out of the circulating plasma. Osmotic swelling of erythrocytes is considered not to have occurred, judging from the constant level in the saturation index of the blood.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1238
    Keywords: Key words Adult respiratory distress syndrome ; Nitric oxide ; Sheep ; Lung lavage ; Pulmonary circulation ; Pressure-flow relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Inhalation of nitric oxide (NO) selectively dilates pulmonary vessels in well-ventilated regions. Prostaglandin F2α (PGF2α) is a vasoconstrictor and is reported to enhance hypoxic pulmonary vasoconstriction. The objective of this study was to examine whether the combination of intravenous PGF2α and inhaled NO in ARDS lungs has a beneficial effect on oxygenation. Design: We investigated the effect of intravenous PGF2α infusion (0.05–10.0 μg/kg per min) with and without NO inhalation (60 ppm) on the hemodynamics and gas exchange in an ovine ARDS model, examining the pulmonary artery pressure versus the flow plot by varying cardiac output. Measurements and results: After lung lavage, NO inhalation reduced the mean pulmonary arterial pressure (MPAP) by decreasing the zero-flow pressure intercept from 10.6±3.8 (mean±SD) to 8.5±3.8 mmHg (p〈0.05) with no significant change in slope. NO inhalation improved PaO2 from 56±12 to 84±38 mmHg (p〈0.005) and reduced pulmonary shunt from 65±5 to 53±8% (Qs/Qt) (p〈0.001). The dose-dependent effects of PGF2α infusion were: (1) increased MPAP attributed to an increased slope in pulmonary artery pressure-flow plot; (2) decreased cardiac index; (3) decreased Qs/Qt with unchanged PaO2. The dose-dependent decrease in Qs/Qt after PGF2α infusion was attributed to the decreased cardiac output. Conclusions: It is suggested that inhalation of NO reduced the critical vascular pressure near alveoli without affecting upstream vessels, while infused PGF2α constricted the larger upstream pulmonary artery vessels without appreciably affecting the critical pressure. Inhalation of NO into well-ventilated lung areas shifted perfusion to well-oxygenated areas, and there was no supplemental shift in blood flow by adding an infusion of PGF2α.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1211
    Keywords: Key words HLA ; Peptide ; VKH disease ; Tyrosinase ; T-cell response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Human T-cell-mediated autoimmune diseases are often genetically linked to particular alleles of HLA class II genes. Vogt-Koyanagi-Harada’s (VKH) disease, which is regarded as an autoimmune disorder in multiple organs containing melanocytes, has been found to be associated with HLA-DR4 (DRB1*0405) and HLA-DR53 (DRB4*0101). Tyrosinase is a melanoma antigen (Ag) expressed by normal melanocytes as well as melanoma cells against which responses by autologous T cells have been detected. We established a T-cell line from the peripheral blood of a patient with VKH disease which responded to synthetic peptides corresponding to tyrosinase. The T-cell line was generated which recognized the tyrosinase p188 – 208 peptide when presented by the HLA-DR4 (DRB1*0405) molecule on the surface of HLA class II-expressing L-cell transfectants. The minimal antigenic peptide which induced T-cell responses was an 11-amino-acid sequence and located at tyrosinase p193 – 203 (E-I-W-R-D-I-D-F-A-H-E). This peptide contained the DRB1*0405-binding peptide motif (hydrophobic residues (Y, F, W) at position 1 as an anchor residue, and negatively charged residues (D, E) at position 9), which corresponded to the W at p195 and the D at p203. These observations demonstrate that tyrosinase peptides are immunogenic, and may be a candidate for an autoantigen in VKH disease, suggesting that probing the T-cell responses against synthetic peptides is a productive approach for identifying the autoantigenic peptides associated with autoimmune diseases including VKH disease.
    Type of Medium: Electronic Resource
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