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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 33 (1994), S. 3852-3854 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 5417-5423 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 7 (1968), S. 2653-2662 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Intensivmedizin ; Surveillance ; Infektionsraten ; Prävention ; Qualitätsmanagement ; Keywords Intensive care ; Surveillance ; Prevention ; Quality management ; Infection rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Objectives. To establish a surveillance system as an element of internal quality management, participating intensive care units (ICUs) report their ICU-associated infection surveillance data for aggregation into a national database. Methods. In order to provide data on ICU-associated infections, a nosocomial surveillance system in German intensive care units (Krankenhaus-Infektions-Surveillance-System (KISS)) started in 1997. The method of data collection is based on the (adult) ICU surveillance component from the National Nosocomial Infections Surveillance (NNIS)-System. Until now 113 German ICUs (most of them medical/surgical ICUs) were included in this system. We continuously collected and calculated the data from site-specific infections (device-associated pneumonias, blood stream infections and urinary tract infections). Results. There are now a total of 393.177 patient-days (100.015 patients) among them 176.415 ventilator-days, 295.221 central line-days and 316.799 urinary catheter-days in the data base. The data analysis showed the following device-associated infection rates: 11.2 pneumonias/1000 ventilator-days, 1.8 primary bloodstream infections/ 1000 central line-days and 4.0 urinary tract infections/1000 urinary catheter-days. Conclusion. The project has reached high interest in Germany and animated more ICUs to take part or to apply the same method in order to use the reference data for comparison.
    Notes: Zusammenfassung Die fortlaufende, systematische Erfassung, Analyse und Interpretation (=Surveillance) nosokomialer Infektionsraten spielt die wesentliche Rolle bei der Problemidentifikation und der nachfolgenden Problemlösung im Rahmen der Infektionsprävention. Ziel des Nationalen Referenzzentrums für Krankenhaushygiene und des Robert Koch-Instituts war die Etablierung einer einheitlichen Surveillance-Methode auf mehreren Intensivstationen und die Bereitstellung der gewonnenen Daten als nationale Referenzdaten. Seit Januar 1997 wird für Deutschland eine Referenzdatenbank zur Surveillance nosokomialer Infektionen auf Intensivstationen aufgebaut. Auf 113 Intensivstationen wurden bisher die Daten von 100.015 Patienten (393.177 Patiententage) erfasst. Als Methode der Standardisierung wird die Anzahl der Infektionen, die während der Anwendung eines Risikofaktors auftreten (Harnwegskatheter, ZVK oder maschinelle Beatmung) auf die Anwendungshäufigkeit des Risikofaktors bezogen (“device”-assoziierte Infektionsrate). Folgende “device”-assoziierten Infektionsraten wurden ermittelt: 4, 0 Harnwegsinfektionen/1.000 Harnwegskathetertage, 1, 8 primäre Septikämien/1000 ZVK-Tage und 11, 2 Pneumonien/1.000 Beatmungstage (Mittelwerte). Durch den Vergleich der eigenen Daten mit denen der Referenzdatenbank haben Intensivstationen Gelegenheit, Anhaltspunkte für eine Optimierung von Präventionsmaßnahmen zu erhalten.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 25 (2000), S. 286-289 
    ISSN: 1432-0509
    Keywords: Key words: Gaucher disease—Spleen in Gaucher disease—Splenic nodules—Computed tomography—Magnetic resonance imaging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a 26-year-old male patient with Gaucher disease who presented with epigastric pain and a palpable mass in the left abdomen. Ultrasound, abdominal computed tomography, and magnetic resonance imaging showed massive splenomegaly with multiple splenic nodules up to 7 cm in diameter. Splenic nodules should be included in the differential diagnosis of splenic masses. Follow-up is necessary because of the increased incidence of hematologic malignancies in Gaucher disease.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1440
    Keywords: HIV infection ; AIDS ; Pneumocystis carinii pneumonia ; Pentamidine inhalation ; Prophylaxis ; Pneumocystoma ; Nodular infiltrates ; Pulmonary masses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atypical pulmonary manifestations of Pneumocystis carinii infection and fair numbers of extrapulmonary and disseminated infections have lately been documented in patients with human immunodeficiency virus infection treated prophylactically with inhalative pentamidine. We report the case of a 32-year-old homosexual patient who was assessed for complaints of night sweats, weight loss, and progressive malaise. The patient denied any respiratory tract symptoms such as cough, sputum production, pleuritic chest pain, or shortness of breath. Chest X-ray revealed two large round noncavitating lesions in the lower lobe of the right lung. Pneumocystomas were diagnosed by fine-needle aspiration. A 3-week course of intravenous high-dose cotrimoxazole resulted in amelioration of symptoms but no change in the radiographic appearance of the pulmonary lesions. Four months later the patient is alive and stable and is being treated with pentamidine inhalation of 300 mg per 2 weeks and two tablets of pyrimethamine sulfadoxine per week.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 168 (1999), S. 131-139 
    ISSN: 1432-1424
    Keywords: Key words: Cell shrinkage — Volume regulation — Patch clamp — Cell lines — Flufenamate — Cation channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Osmotic cell shrinkage activates a nonselective cation (NSC) channel in M-1 mouse cortical collecting duct cells (Volk, Frömter & Korbmacher, 1995, Proc. Natl. Acad. Sci. USA 92: 8478-8482). To see whether shrinkage-activated NSC channels are an ubiquitous phenomenon, we tested the effect of hypertonic extracellular solution on whole-cell currents of HT29 human colon carcinoma cells, BSC-1 renal epithelial cells, A10 vascular smooth muscle cells, and Neuro-2a neuroblastoma cells. Addition of 100 mm sucrose to an isotonic NaCl bath solution induced cell shrinkage of HT29 cells as evidenced by a decrease in cell diameter from 18 ± 1 μm to 12 ± 1 μm (n= 13). Upon cell shrinkage whole-cell currents of HT29 cells increased within 8 ± 1 min by about 30-fold (n= 13). Cell shrinkage and current activation were reversible upon return to isotonic solution. Replacement of bath Na+ by K+ or Li+ had almost no effect on the stimulated inward current. In contrast, replacement by N-methyl-d-glucamine (NMDG) completely abolished it and shifted the reversal potential from −4.5 ± 0.7 mV to −57 ± 4.1 mV (n= 10). Thus, the stimulated conductance is nonselective for alkali cations but highly selective for cations over anions with a cation-to-anion permeability ratio of about 13. Flufenamic acid (100 μm) inhibited the stimulated current by 84 ± 4.7% (n= 8). During the early phase of hypertonic stimulation single-channel transitions could be detected in whole-cell current recordings, and a gradual activation of 12 and more individual channels with a single-channel conductance of 17.6 ± 0.9 pS (n= 4) could be resolved. In analogous experiments similar shrinkage-activated NSC channels were also observed in BSC-1 renal epithelial cells, A10 vascular smooth muscle cells, and Neuro-2a neuroblastoma cells. These findings indicate that shrinkage-activated NSC channels are an ubiquitous phenomenon and may play a role in volume regulation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 177 (2000), S. 231-242 
    ISSN: 1432-1424
    Keywords: Key words: Cell shrinkage — Volume regulation — Patch clamp — Nonselective cation channels — Cytoskeleton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. It has previously been shown that osmotic cell shrinkage activates a nonselective cation (NSC) channel in M-1 mouse cortical collecting duct cells [54] and in a variety of other cell types [20]. In the present study we further characterized the shrinkage-activated NSC channel in M-1 cells and its mechanism of activation using whole-cell current recordings. Osmotic cell shrinkage induced by addition of 100 mm sucrose to the bath solution caused a 20-fold increase in whole-cell inward currents from −10.8 ± 1.5 pA to −211 ± 10.2 pA (n= 103). A similar response was observed when cell shrinkage was elicited using a hypo-osmotic pipette solution. This indicates that cell shrinkage and not extracellular osmolarity per se is the signal for current activation. Cation substitution experiments revealed that the activated channels discriminate poorly between monovalent cations with a selectivity sequence NH4 (1.2) ≥ Na+ (1) ≈ K+ (0.9) ≈ Li+ (0.9). In contrast there was no measurable permeability for Ca2+ or Ba2+ and the cation-to-anion permeability ratio was about 14. The DPC-derivatives flufenamic acid, 4-methyl-DPC and DCDPC were the most effective blockers followed by LOE 908, while amiloride and bumetanide were ineffective. The putative channel activator maitotoxin had no effect. Current activation was dependent upon the presence of intracellular ATP and Mg2+ and was inhibited by staurosporine (1 μm) and calphostin C (1 μm). Moreover, cytochalasin D (10 μm) and taxol (2 μm) reduced the current response to cell shrinkage. These findings suggest that the activation mechanism of the shrinkage-activated NSC channel involves protein kinase mediated phosphorylation steps and cytoskeletal elements.
    Type of Medium: Electronic Resource
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