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  • 1
    Electronic Resource
    Electronic Resource
    Successful 96- and 144-hour experimental kidney preservation: A combination of standard machine preservation and newly developed normothermic ex vivo perfusion
    Amsterdam : Elsevier
    Cryobiology 17 (1980), S. 473-477 
    Details
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0011-2240(80)90057-7
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  • 2
    Electronic Resource
    Electronic Resource
    Preoperative imaging of a choledochal cyst in children: non-breath-holding magnetic resonance cholangiopancreatography (1999)
    Springer
    Pediatric surgery international 15 (1999), S. 546-548 
    Details
    ISSN: 1437-9813
    Keywords: Key words Cholangiography ; Choledochal cyst ; Cholestasis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance cholangiopancreaticography (MRCP) was used to visualize the biliary tract in two children, aged 7 weeks and 10 years, with a choledochal cyst. MRCP was successful in both cases and the findings were confirmed by intraoperative cholangiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050667
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  • 3
    Electronic Resource
    Electronic Resource
    Cadaveric organ retrieval for transplantation (1982)
    Springer
    World journal of surgery 6 (1982), S. 478-483 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Pour pallier l'insuffisance persistante des organes de cadavre à transplanter, le prélèvement des organes doit devenir une méthode systématique dans tout hôpital général. A cet effet, l'article décrit la sélection des donneurs, le traitement de ceux-ci, les techniques de prélèvement des reins, du foie, du pancréas et les méthodes de conservation des organes prélevés. Les critères d'organisation d'un programme régional de prélèvements d'organes impliquant un coordinateur sont définis.
    Notes: Abstract To relieve the persistent shortage of cadaveric donor organs for transplantation, organ harvesting may become a routine procedure in all general hospitals. Because of that prospect, the selection of donors, donor management, techniques of nephrectomy, hepatectomy, and pancreatectomy, and preservation procedures are described. Finally, criteria for the establishment of regional procurement programs, involving a professional transplant coordinator, are elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01657686
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    90. Die halboeffene Behandlung der eitrigen Peritonitis (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 322-322 
    Details
    ISSN: 1435-2451
    Keywords: Generalized peritonitis ; Open-wound treatment ; Marlex-mesh ; Diffuse Peritonitis ; Offene Wundbehandlung ; Marlex-Netz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dem bewähren chirurgischen Prinzip entsprechend eine infizierte Wunde offen zu behandeln, verschließ wir die Bauchhöhle bei schwerer Perforationsperitonitis nicht. Es wird auf Darmnähte und Anastomosen verzichtet, Drains werden eingelegt und ein für Flüssigkeit durchlässiges Marlex-Next wird in die offene Wunded eingenäht. So lange wie möglich wird gespült. Es wird über 17 Patieten mit einer Kombination von schwerer Perforationsperitonitis und ≫multiple organ disease≪ berichtet. Durch diese Methode wurde es ermöglicht, die ehemalige Letalität von 50 auf 25% herabzusetzen.
    Notes: Summary According to approved surgical principles of open treatment of infected wounds, we refrained from closing the abdominal wall in cases of severe generalized peritonitis. Suture lines of intestines and anastomoses were avoided, drains were established, and permeable Marlex-Mesh was sutured into the abdominal wall defect. Lavage was practiced as long as possible. All 17 patients suffering from severe generalized peritonitis and 〉multiples organ diseases〈 were treated in this way, and mortality went down from 50% to 25%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292051
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  • 5
    Electronic Resource
    Electronic Resource
    Open or laparoscopic preperitoneal mesh repair for recurrent inguinal hernia? (1999)
    Springer
    Surgical endoscopy and other interventional techniques 13 (1999), S. 323-327 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Inguinal hernia — Laparoscopy — Mesh — Randomized trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Giant prosthetic reinforcement of the visceral sac (GPRVS), an open preperitoneal mesh repair, is a very effective groin hernia repair. Laparoscopic transabdominal preperitoneal repair (TAPP), based on the same principle, is expected to combine low recurrence rates with minimal postoperation morbidity. Methods: Seventy-nine patients with 93 recurrent and 15 concomitant primary inguinal hernias were randomized between GPRVS (37 patients) and TAPP (42 patients). Operating time, complications, pain, analgesia use, disability period, and recurrences were recorded. Results: Mean operating time was 56 min with GPRVS versus 79 min with TAPP (p 〈 0.001). Most complications were minor, except for a pulmonary embolus and an ileus, both after GPRVS. Patients experienced less pain after a laparoscopic repair. Average disability period was 23 days with GPRVS versus 13 days with TAPP (p= 0.03) for work, and 29 versus 21 days, respectively (p= 0.07) for physical activities. Recurrence rates at a mean follow-up of 34 months were 1 in 52 (1.9%) for GPRVS versus 7 in 56 (12.5%) for TAPP (p= 0.04). Hospital costs in U.S. dollars were comparable, with GPRVS at $1,150 and TAPP at $1,179. Conclusions: Laparoscopic repair of recurrent inguinal hernia has a lower morbidity than GPRVS. However, laparoscopic repair is a difficult operation, and the potential technical failure rate is higher. With regard to recurrence rates, the open preperitoneal prosthetic mesh repair remains the best repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900981
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  • 6
    Electronic Resource
    Electronic Resource
    Diabetes induction and pancreatic transplantation in the cynomolgus monkey: methodological considerations (1991)
    Springer
    Transplant international 4 (1991), S. 103-109 
    Details
    ISSN: 1432-2277
    Keywords: Pancreatic transplantation, in the monkey ; Diabetes induction, in the monkey ; Streptozotocin, in the monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to develop a model for pancreatic transplantation in the primate in order to test a new immunosuppressive drug. Initially, streptozotocin was used to induce insulin-dependent diabetes mellitus, but it was found to be ineffective and associated with a high morbidity. Furthermore, streptozotocin-induced insulin-dependent diabetes mellitus did not always persist, thus invalidating the evaluation of pancreatic graft function. Therefore, total pancreatectomy was introduced and combined with the pancreatic allotransplantation as a single procedure. Enteric diversion of the pancreatic juice was chosen since this avoids exocrine pancreatic insufficiency and facilitates the oral administration of the test drug. Intra-arterial monitoring of blood pressure and blood gases during the operation and avoidance of hypothermia in the animal were found to be the most improtant factors contributing to a successful outcome from the operative procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336407
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  • 7
    Electronic Resource
    Electronic Resource
    Retrograde oxygen persufflation in combination with UW solution enhances adenine nucleotide contents in ischemically damaged rat kidney during cold storage (1996)
    Springer
    Transplant international 9 (1996), S. 396-402 
    Details
    ISSN: 1432-2277
    Keywords: Kidney, preservation, retrograde oxygen ; Preservation, kidney, retrograde oxygen ; Retrograde oxygen, preservation, kidney ; Adenosine, kidney, preservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Retrograde oxygen persufflation (ROP) has been reported to be beneficial to kidney preservation. The purpose of this study was to investigate whether use of ROP during cold storage (CS) with Universita of Wisconsin (UW) solution could ameliorate energy metabolism and functional recovery of ischemically injured rat kidneys and, moreover, to study the particular role of adenosine (ADO) in CS with ROP. Kidneys subjected to 30 min of warm ischemia (WI) were preserved for 24 h in 4°C UW solution with or without ROP and with or without ADO. Measurements of tissue highenergy phosphate levels showed that reduced total adenine nucleotides (TAN) after 30 min of WI further declined during the subsequent CS. In ROP kidneys, however, TAN were less reduced, suggesting that even during CS, TAN can still be regenerated in the injured kidneys when ROP is combined with UW solution. When UW did not contain ADO, regeneration of TAN by ROP was slightly less than in the case of UW with ADO. This indicates that the supply of molecular oxygen is a significant factor in TAN resynthesis during CS. There was no statistically significant difference in survival rate between the ROP and CS group, indicating that an improved energy status is not the sole determinant of functional recovery. We conclude that the gaseous oxygen supply provided by ROP during CS in UW solution ameliorates the energy state of ischemically injured rat kidneys and that exogenous ADO from the UW solution contributes to the improvement of energy metabolism to a limited extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335702
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  • 8
    Electronic Resource
    Electronic Resource
    Vascular anatomy in abdominal surgery (1991)
    Springer
    Transplant international 4 (1991), S. 193-193 
    Details
    ISSN: 1432-2277
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335344
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  • 9
    Electronic Resource
    Electronic Resource
    Outcome of machine-perfused non-heart-beating donor kidneys, not allocated within the Eurotransplant area (1998)
    Springer
    Transplant international 11 (1998), S. S421 
    Details
    ISSN: 1432-2277
    Keywords: Key words Non-heart-beating ; Donor kidney ; Machine perfusion ; Viability assessment ; Kidney transplantation ; αGST
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eleven non-heart-beating (NHB) donor kidneys considered vital during machine perfusion (MP), could not be allocated inside Eurotransplant (ET). With the help of ET, five kidneys were transplanted in Karachi and six in Basel. Our goal was to prove that NHB kidneys successfully passing MP viability tests can be transplanted safely. Methods: Donor age, serum creatinine (some post-mortem) and warm ischaemic time were, respectively, (mean and range): 44 (14–70) years, 137 μmol/l, and 44 (9–80) min. Reasons for refusal were: bold ureter (one), suboptimal flush (one), relatively long hypotensive phase (seven), and donor age of 70 years (two). After 8 h of MP, mean lactate dehydrogenase, intrarenal resistance and alpha glutathione S-transferase were (including range): 556 U/l (range 366–819 U/l), 0.86 mmHg/ml per min (0.41–1.15 mmHg/ml per min) and 1188 μg/l (575–2677 μg/l), respectively. Mean cold ischaemic time was 45 (range 28–72) h. Results: Two kidneys showed immediate function, and nine showed delayed function. Mean creatinine levels after 1, 3 and 6 months were 295, 200 and 206 μmol/l, respectively. Four patients died for reasons not related to their kidney transplantation. Conclusions: We claim that MP can successfully assess viability of NHB donor kidneys. The reluctance to accept MP, and judged vital, NHB donor kidneys is no longer justified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050513
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibition of CD18-dependent leukocyte adherence by mAb 6.5 E does not prevent ischemia-reperfusion injury as seen in grafted kidneys (1995)
    Springer
    Transplant international 8 (1995), S. 126-132 
    Details
    ISSN: 1432-2277
    Keywords: Ischemia, leukocyte adherence, dog kidney ; Reperfusion, leukocyte adherence, dog kidney ; Leukocyte adherence, reperfusion, dog kidney ; Monoclonal antibody, leukocyte adherence, reperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was designed to determine whether β-2 integrin-mediated leukocyte adherence to the endothelium is involved in renal ischemia-reperfusion damage and to evaluate the therapeutic intervention potency of monoclonal antibody (mAb) 6.5 E, directed against the leukocyte CD18 adhesion molecule. To answer these questions, we used a clinically relevant canine model for the autotransplantation of kidneys that had been subjected to 30 min of normothermic ischemia, followed by 24 h of cold storage preservation. Intravital fluorescence microscopy of capsular microvessels showed that substantial leukocyte adherence occurred after renal ischemia and reperfusion. Leukocyte adherence was observed in both arterioles and venules, but predominantly in the latter. Reperfusion of the graft resulted in a statistically significant reduction of the venular red blood cell velocity (RBCV). Moreover, the venular diameter increased. No significant changes in the arteriolar RBCV or in the arteriolar diameter were observed. Administration of mAb 6.5 E, 1 h before reperfusion, inhibited leukocyte adherence to the renal microvascular endothelium, resulting in an improved venular flow 2 h after reperfusion. However, we observed no beneficial effect of mAb 6.5 E pretreatment on posttransplant graft function and survival. We conclude that leukocyte adherence does not play a critical role in the development of renal injury following reperfusion of kidneys that have been subjected to prolonged warm and cold ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344422
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