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  • 1
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 48 (1999), S. 549-557 
    ISSN: 1432-055X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Geo-marine letters 18 (1998), S. 97-114 
    ISSN: 1432-1157
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Drilling two mud domes on the Mediterranean Ridge during ODP Leg 160 has demonstrated that the eruption of mud breccia began at least 1.5 Ma ago. An evolution through extrusive building of a cone, followed by successive eruptions of clast-bearing mud debris flows and subsequent subsidence can be deduced for both domes. Results from permeability and shear strength tests, grain size analyses, sedimentary textures, and clast provenance provide clues concerning the mechanism of mud volcanism. The collision of Africa with Eurasia resulted in backthrusting of the evaporite-dominated accretionary wedge against a rigid backstop. This allowed egress of overpressured fluid-rich mud of presumed Messinian age from the décollement, although many of the clasts may have originated from the overlying accretionary wedge.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 6945-6955 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report results of a molecular dynamics simulation of an "isotope" mixture of polymer chains, which are represented by a standard bead–spring model, and whose two species differ only by their monomer masses. Detailed analysis of the Rouse modes shows that for sufficiently short (non-entangled) chains this system can be well described by the Rouse model. Each species is described by its individual monomeric friction coefficient, whose dependence on both mass ratio as well as mixing ratio is studied. The main effect of mixing is an acceleration of the slower chains and a slowdown of the faster ones, while both species remain dynamically different. Some microscopic insight into the mechanism is obtained by studying the short-time behavior of the monomeric velocity autocorrelation function. Studies in the slightly entangled regime (chain length up to N=150, where the typical entanglement chain length is Ne(approximate)35) seem to further corroborate the hypothesis that the "tube diameter" of the reptation model is a quantity which results mainly from the static configurations, i.e., is an equilibrium thermal average. The usefulness of recently suggested analysis methods in this regime is briefly discussed. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 29 (2002), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty consecutive patients suffering from myofascial pain dysfunction (MPD) were assigned to a waiting-list, serving as a no-treatment control period. Inclusion criteria were: (i) pain in the temporomandibular region for at least 3 months, (ii) no evidence of internal derangement or osteoarthritis and (iii) symptoms of postural dysfunction. Treatment consisted of active and passive jaw movement exercises, correction of body posture and relaxation techniques. The following main outcome measures were evaluated: (i) pain at rest, (ii) pain at stress, (iii) impairment, (iv) mouth opening at base-line, before and after treatment and at 6-month follow-up. All patients completed the study and no adverse effects occurred. During control period no significant changes occurred. After treatment six patients had no pain at all (chi-square: P 〈 0·01) and seven patients experienced no impairment (chi-square: P 〈 0·005). Pain at stress, impairment and incisal edge clearance improved significantly (Wilcoxon test P 〈 0·001). This result did not change until follow up, except pain at stress, which further improved significantly (Wilcoxon test P 〈 0·03). At follow up 16 patients experienced no pain at all, 13 patients were not impaired and only three patients had a restricted mouth opening, in contrast to 12 before treatment (chi-square test P 〈 0·001). Conclusion:  Exercise therapy seems to be useful in the treatment of MPD Syndrome.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study intended in evaluating the effectiveness of exercise therapy in patients with craniomandibular disorders (CMD). Twenty consecutive patients suffering from CMD with anterior disc displacement without reduction consulting a CMD service were included in the study if they met following criteria: (i) pain in the temporomandibular region, (ii) reduced incisal edge clearance (〈35 mm), (iii) magnet resonance imaging confirmed anterior disc displacement without reduction and (iv) evidence of postural dysfunction. All patients were assigned to a waiting list, serving as a no-treatment control period, according to a before–after trial. The treatment consisted of active and passive jaw movement exercises, correction of body posture and relaxation techniques. A total of 18 patients completed the study, no adverse effects occurred. Following main outcome measures were evaluated: (1) pain at rest (2) pain at stress (3) impairment (4) mouth opening at base-line, before and after treatment and at 6 month follow-up. As a result of treatment pain, impairment and mouth opening improved significantly more than during control period (paired samples t-test P 〈 0·05). After treatment four patients had no pain at all (chi-square: P 〈 0·05) and only seven patients revealed an impaired incisal edge clearance after treatment. (chi-square Test, P 〈 0·001). At follow up, seven patients had no pain and experienced no impairment. Exercise therapy seems to be useful in the treatment of anterior disc displacement without reduction.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Atypical mole syndrome is a sporadic or an inherited condition with an increased risk of melanoma. Germline mutations in the CDKN2A, ARF, CDK4 and somatic mutations in the PTEN and BRAF genes have been associated with melanoma. In this study, we evaluated genes associated with familial and sporadic melanoma for mutations in 28 probands with the atypical mole syndrome. No sequence alterations in the coding regions or in the splice junctions of CDKN2A, ARF, CDK4, PTEN or BRAF were identified. These data suggest that genes evaluated in this study are unlikely to be candidate genes for atypical mole syndrome and support the notion that unknown susceptibility gene/s for this disease exist.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Fluency Disorders 19 (1994), S. 186 
    ISSN: 0094-730X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Linguistics and Literary Studies , Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Atypical melanocytic nevi (AMN) share some or all of the clinical features of malignant melanoma (MM). The clinical sensitivity for diagnosing MM by physicians experienced in evaluating pigmented lesions is reported to range from 73% to 89%. This study attempted to determine whether clinical sensitivity can be increased by dermoscopy (epilumnescence microscopy, dermatoscopy).〈section xml:id="abs1-2"〉〈title type="main"〉Methods: A total of 72 melanocytic neoplasms were histologically diagnosed as either AMN or early MM (〈1 mm Breslow thickness). Prior to excisional biopsy, each lesion was photographed without oil being applied to its surface (clinical photo); subsequently it was photographed with oil applied (dermoscopic photo). Each 35 mm color transparency, visualized on a rear-view projector, was analyzed by two experienced and two less experienced observers. Each of them recorded one clinical, one “overall” dermoscopic, and one “scored” dermoscopic diagnosis: either AMN or MM for each.〈section xml:id="abs1-3"〉〈title type="main"〉Results: Histologically, 21 lesions were diagnosed as MM and 51 as AMN. The observers, except one of the less experienced, had an increase in sensitivity ranging from 5 to 15% for diagnosing MM with dermoscopy. The increase was higher for the scored dermoscopy than for overall dermoscopy. Diagnostic Accuracy (DA) changed from −20% to +11%. Specificity (SP) changed from −23% to +24% with scored dermoscopy. Three of the 21 MMs were missed by one or more observers using all three in vivo diagnostic methods.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions: In this study dermoscopy, when used by experienced dermatologists, increased diagnostic sensitivity and index of suspicion but decreased specificity and diagnostic accuracy for diagnosing MM. Therefore, dermoscopy may result in an increased number of biopsies of benign lesions (AMN), but would decrease the probability of missing MM.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Skin research and technology 3 (1997), S. 0 
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Differentiation between early (Breslow thickness less than 1 mm) malignant melanoma (MM) and atypical melanocytic nevus (AMN) remains a challenge even to trained clinicians. The purpose of this study is to determine the feasibility of reliable discrimination between early MM and AMN with noninvasive, objective, automatic machine vision techniques.Methods: A data base of 104 digitized dermoscopic color transparencies of melanocytic lesions was used to develop and test our computer-based algorithms for classification of such lesions as malignant (MM) or benign (AMN). Histopathologic diagnoses (30 MM and 74 AMN) were used as the “gold standard” for training and testing the algorithms.Results: A fully automatic, objective technique for differentiating between early MM and AMN from their dermoscopic digital images was developed. The multiparameter linear classifier was trained to provide 100% sensitivity for MM. In the blind test, this technique did not miss a single MM and its specificity was comparable to that of skilled dermatologists.Conclusions: Reliable differentiation between early MM and AMN with high sensitivity is possible using machine vision techniques to analyze digitized dermoscopic lesion images.
    Type of Medium: Electronic Resource
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