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  • 1
    ISSN: 1432-1440
    Keywords: 125J-fibrinogen uptake test ; Venous thrombosis ; Anticoagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sensitivity of the radiofibrinogen test was investigated to determine the accuracy of the test in diagnosis of venographically proven venous thrombosis in 70 heparinized patients.125J-fibrinogen was administered between 2 h and 4 days (mean: 1.5 days) after initiating heparin therapy. There were two criteria for a positive test: (a) if the difference between the counts for adjacent points on the same leg or equivalent sites on opposite legs was at least 15%; and/or (b) if there were three adjacent points each with counts 〉5% that of the same three points on the other leg. The fibrinogen uptake test was positive at the first examination in 67 of 70 patients, giving a sensitivity of 96%. The respective frequencies of truly abnormal results for the 3×5% and the 1×15% criteria were 94% and 71%. As far as localization and extension of thrombosis were concerned, the fibrinogen uptake test agreed with phlebography in 73% of the cases, when the counts in the groin and the upper third of the thigh were ignored. The125J-fibrinogen uptake test is an accurate method for detecting established deep leg vein thrombosis even in anticoagulated patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 552-555 
    ISSN: 1432-1440
    Keywords: Hodgkin's disease ; Hypothermia ; Exploratory laparotomy ; Corticosteroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypothermia is a rare complication of unknown origin in Hodgkin's disease which has been reported after the administration of antineoplastic agents, chlorpromazine and paracetamol. We report a highly febrile patient with stage IV-B Hodgkin's disease of mixed cellularity type who underwent exploratory laparotomy. Because of suspected septic shock high-dose prednisolone was given during surgery. Postoperatively the patient's body temperature fell progressively to 32.9° C and remained at less then 35.5° C for the following 5 days. There seems to be some functional disorder of thermoregulation in Hodgkin's disease. Physical factors during surgery or certain drugs, especially cytotoxics, corticosteroids, anesthetics or antipyretics may lead to prolonged hypothermia.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Hemorheology ; Acute Phase Proteins ; Vascular Surgery ; Carotid Arteries ; Arterial Occlusive Diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 39 patients with hemodynamically significant stenoses of the internal carotid artery thrombendarterectomy was performed. Hemorheological properties and plasma protein levels were studied pre- and postoperatively over a period of 14 days. In comparison to age-matched healthy controls preoperative plasma viscosity, red cell aggregation, fibrinogen, haptoglobin and alpha-1-antitrypsin were significantly elevated. After surgical trauma there was an increase in fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin, whereas alpha-2-macroglobulin, immunglobulin A and immunglobulin G decreased significantly. Plasma viscosity, red cell aggregation, red cell filterability, fibronectin and immunglobulin M remained unchanged. We conclude that our patients showed a non specific chronic “hematological stress syndrome” with raised acute phase reactants and corresponding hemorheological changes preoperatively; despite postoperative acute phase reaction no further deterioration of the rheological parameters could be observed; this might be caused by a decrease of plasma proteins with high frictional ratios compensating the increase of acute phase proteins. Besides, tissue damage and consecutive acute phase reaction in carotid arterial surgery seem to be of relatively minor degree.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Periarteritis nodosa ; Magnetic resonance imaging ; Cerebral lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The course is reported of a patient with periarteritis nodosa who initially presented with neurological symptoms. Multiple cerebral lesions were documented by the first magnetic resonance imaging (MRI) investigation. The majority of these had disappeared completely in the follow-up MRI studies. In contrast to neurological improvement the patient eventually died due to multiorgan failure. Postmortem histological examination revealed no pathological findings in the brain except one single necrotic area already known from MRI. Remissions of histological and angiographic alterations in periarteritis nodosa have been described as “local healing” leading to fibrosis and scarring. Our findings suggest that restitutio ad integrum may occur, at least in cerebral lesions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 324-324 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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