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  • 1
    Electronic Resource
    Electronic Resource
    Diphenylhydantoin (DPH) blocks HIV-receptor on T-lymphocyte surface (1986)
    Springer
    Annals of hematology 53 (1986), S. 447-450 
    Details
    ISSN: 1432-0584
    Keywords: Diphenylhydantoin ; T-Lymphocyte ; HIV-Receptor ; Radioactive labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous reports have shown the capacity of diphenylhydantoin (DPH) to attach to the membranes of lymphatic cells as a hapten and thus exert an unspecific influence on their ability to express certain recognition molecules. This led us to the hypothesis, that DPH might as well serve to manipulate the t-helperlymphocytes in a way that the mode of infection of these cells by the HIV might be blocked. In order to verify this hypothesis, we exposed normal control lymphocytes as well as lymphocytes from DPH-treated patients (3×100–150 mg DPH/day, Phenhydan®, for a minimum of 10 days) to radioactively labeled HIV (125I). Remaining radioactivity was assessed using a gamma-counter and measured 64.000–92.000 counts/min (n=24, mean 80.000) for the control lymphocytes, while remaining radioactivity for the DPH-treated lymphocytes ranged between 2000 and 7000 counts/min (n=24, mean 4.000, p〈0.001). These results and similar experiments obtained with FITC-labeled HIV led us to the conclusion that DPH inhibits HIV recognition of T-lymphocytes and therefore might be used in therapy and prophylaxis of AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320308
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Einfluß von Aethanol auf die Neurotransmitter Glutamat und GABA (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 183-189 
    Details
    ISSN: 1433-8491
    Keywords: Ethanol ; Barbiturate ; Cortex ; GABA ; Glutamate ; Hippocampus ; Nigra ; Striatum ; Aethanol ; Barbiturat ; Cortex ; GABA ; Glutamat ; Hippocampus ; Nigra ; Striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In zwei Versuchsserien wurde der Einfluß von chronischer Aethanolgabe (5 g/kg täglich) über 2 bzw. 4 Wochen auf die Neurotransmitter Glutamat und GABA bei Ratten untersucht. Dabei fand sich ein durch Barbiturat maskierter Anstieg der GABA-Konzentration in Striatum, Hippocampus und Substantia nigra, 8 bzw. 12 Stunden nach der letzten Aethanolgabe. Für Glutamat konnte ebenfalls ein Anstieg in den untersuchten Hirnregionen gefunden werden, der mit den für Dopamin bekannten Veränderungen unter Aethanol vereinbar ist. Die Bedeutung für die Pathogenese hirnorganischer Anfälle und psychotischer Symptome nach chronischem Alkoholmißbrauch wird diskutiert.
    Notes: Summary The effect of chronic ethanol administration, 5 g/kg per day for 2 or 4 weeks, on the neurotransmitters glutamate and GABA was investigated in rats. An increase in GABA was found in the striatum, hippocampus, and substantia nigra, 8 or 12 h after the last ingestion of ethanol, this being masked by injection of barbiturate. In addition an increase of glutamate has been found in the examined brain areas. This is consistent with the known effect of ethanol on brain Dopa metabolism and release. Finally, the relevance of the results for the pathogenesis of withdrawal seizures and delirious states is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343699
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    L-glutamate and L-aspartate concentrations in the developing and aging human putamen tissue (1993)
    Springer
    Journal of neural transmission 93 (1993), S. 145-150 
    Details
    ISSN: 1435-1463
    Keywords: Aspartate ; glutamate ; postmortem ; human brain ; putamen ; ontogenesis ; aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously reported that the developmental regulation of NMDA receptor expression in human brain is characterized by a sharp postnatal increase peaking at about age 1 year. We have now extended this work by measuring concentrations of L-glutamate and L-aspartate in the putamen from 45 human autopsy specimens. Both amino acids increased steeply within the first postnatal year after which they remained fairly constant throughout life. There was no impact on glutamate and aspartate levels in putamen of sex, side of the brain, postmortem time and storage time of brain tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245343
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    Paper (German National Licenses)
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