ISSN:
1420-9071
Keywords:
Drug metabolism
;
indoxyl derivatives
;
aldehyde intermediates
;
benzodiazepines
;
benzophenones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01966155
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