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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 56-61 
    ISSN: 1432-1440
    Keywords: Non-Hodgkin's lymphoma ; Gastrointestinal involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1978 and 1983 a total of 33 patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal tract were seen in our institution. Pathological classification was performed according to Kiel. Low grade NHL was diagnosed in 17, high grade NHL in 16 patients. The most frequent histological entity was lymphoplasmocytoid immunocytoma (11 patients). The most common sites of origin were the stomach (23 patients) and the ileocecal region (6 patients). The majority of patients presented with stage I and II disease (20 of 33 patients). As a rule primary therapy consisted of surgery with curative intent. Most of the patients received additional chemotherapy or radiotherapy. Patients with limited disease and complete tumour resection showed long-term survival from 12+ to 57+ months (mean 32.9+ months). Patients with advanced disease (stage III and IV) and only palliative surgery or with lymphoblastic lymphoma had a probability of survival of less than 12 months.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Antibiotika ; Caecum ; Diarrhoe ; Elektrolyt-transport ; Antibiotics ; Caecum ; Diarrhoea ; Electrolyte transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An oral antibiotic treatment with bacitracin, streptomycin, neomycin and nystatin for 2 wk induced growth and electrolyte transport stimulation of the rat caecum. In comparison with controls, caecal dry weight and mucosal surface area increased without histological evidence for enterocolitis. Stools and caecal contents were more liquid. After removal of the contents, caecal net absorption in vivo of fluid, sodium and chloride per unit weight or area were enhanced as was potassium secretion and the transmural electrical potential difference. These findings are similar to those reported for germfree rats or rats fed poorly absorbable polymers. Under all three conditions, osmotic water binding within the intestinal lumen could play an important role and hypothetically explain antibiotic-associated diarrhoea. The stimulation of caecal growth and electrolyte transport may represent adaptive phenomena counteracting the diarrhoea.
    Notes: Zusammenfassung Unter einer oralen Antibiotikakombination von Bacitracin, Streptomycin, Neomycin und Nystatin über 2 Wochen kam es zum Wachstum des Caecums von Ratten und zur Erhöhung des Elektrolyttransports. Im Vergleich zu Kontrollen nahmen Trockengewicht und Schleimhautoberfläche des Caecums zu ohne histologische Zeichen einer Enterocolitis. Stuhl und Caecuminhalt waren flüssiger. Nach Entfernen des Inhalts war die Nettoresorption von Flüssigkeit, Natrium und Chlorid pro Einheit Caecumgewebe in vivo gesteigert, ebenso die Kaliumsekretion und die transmurale elektrische Potentialdifferenz. Diese Befunde entsprechen früheren Beobachtungen an keimfreien Tieren oder an Ratten, die schlecht resorbierbare Substanzen mit der Diät erhalten. Unter allen drei Bedingungen könnte eine osmotische Wasserbindung im Darmlumen eine wichtige Rolle spielen und hypothetisch die antibiotika-assoziierte Diarrhoe erklären. Die Stimulierung von Wachstum und Elektrolyttransport des Caecums kann als der Diarrhoe entgegenwirkender Adaptationsprozeß aufgefaßt werden.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 415-424 
    ISSN: 1432-1440
    Keywords: Thyroid carcinoma ; Thyroid carcinoma, histological types ; Thyroid carcinoma, endemic goiter area ; Thyroid carcinoma, Prognosis ; Thyroid carcinoma, iodine deficiency ; Schilddrüsencarcinom ; Schilddrüsencarcinom, histologische Typen ; Schilddrüsencarcinom, Struma-Endemiegebiet ; Schilddrüsencarcinom, Prognose ; Schilddrüsencarcinom, Jodmangel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die 284 in der Zeit von 1960 bis 1975 im Pathologischen Institut der Universität München als Zentrum des Bayerischen Struma-Endemiegebietes diagnostizierten Schilddrüsenmalignome wurden nach der WHO-Klassifikation neu eingeteilt. In 249 Fällen war eine TNM-Einteilung durchführbar, die 5-Jahres-Überlebensrate in Abhängigkeit vom Tumortyp konnte bei 96 Patienten ermittelt werden. Ein Vergleich mit Nicht-Endemiegebieten und Regionen mit jahrzehntelanger Jodsalzprophylaxe ergibt in dem bayerischen Endemiegebiet ein Überwiegen der prognostisch ungünstigeren Carcinom-Formen mit 45% follikulären, 26% anaplastischen und nur 24% papillären Carcinomen. Nur 30% der Frauen und 25% der Männer waren 5 Jahre postoperativ am Leben, die Überlebensrate ist im internationalen Vergleich schlecht. Die schlechteste Prognose bietet das anaplastische Carcinom, beim follikulären Carcinom ergibt sich eine deutliche Abhängigkeit des biologischen Wachstumsverhaltens vom Differenzierungsgrad. Generell lag bei der Operation bereits in einem hohen Prozentsatz aller SD-Ca-Fälle ein fortgeschrittenes TNM-Stadium vor. Besonders die mit 60% niedrige 5-Jahres-Überlebensrate bei Patienten mit papillären Carcinomen werden dadurch erklärt. Diese zeigten bei der Operation in 45% ein organüberschreitendes Wachstum, in 65% regionäre Lymphknotenmetastasen und mit 21% eine für diesen Carcinomtyp hohe Rate an Fernmetastasen. Anhand einer detaillierten Aufschlüsselung des Untersuchungsmaterials werden als Ursachen dafür die in einem Kropfgebiet zu späte Entdeckung des Carcinoms bei in 96% präexistenter Struma benigna, der Jodmangel und eine chronisch erhöhte TSH-Stimulation diskutiert.
    Notes: Summary 284 primary thyroid carcinomas collected in the Bavarian endemic goiter area between 1960 and 1975 were reclassified according to the WHO-classification: 45% were follicular, 26% anaplastic, 24% papillary and 3.2% medullary carcinomas, the rest were squamous cell carcinomas and other malignomas. 17.1% of the patients had been operated for benign goiter, on an average of 15.4 years before the operation for thyroid carcinoma. Of these patients, 67% had follicular carcinoma. An analysis based on the TNM-system of 249 cases and the 5-year survival rate of 96 patients revealed unfavourable biological tumour behaviour and bad prognosis in patients operated on before 1970. Only 30% of the women and 25% of the men were alive 5 years p.op. Biological tumour behaviour and prognosis were most unfavourable in patients with anaplastic carcinoma, and were clearly correlated with the grade of histological differentiation of follicular carcinoma, since 52% of patients with well differentiated and 25% of patients with moderately differentiated follicular carcinomas were alive 5 years after operation. A high percentage of papillary carcinomas was at an advanced stage and 21% had distant metastases at the time of operation, probably due to delayed detection of papillary carcinomas in goitrous glands. Accordingly, the 5-years survival rate of patients with papillary carcinoma was only 60%. Comparison with middle European areas without endemic goiter and those with longterm iodine-prophylaxis showed significant differences in distribution of the main histological types of thyroid carcinoma. The reasons for the predominance of the prognostically more unfavourable follicular and anaplastic carcinomas in 71% of our own material and the relatively bad survival rates of the patients from the Bavarian endemic goiter area are discussed with regard to iodine deficiency, TSH-stimulation and the late detection of carcinomas in goitrous thyroid glands.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 48 (1970), S. 244-245 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To become acquainted with the pathomechanism of uremic enterocolitis the cell cycle in the epithelium of the small and large bowel of mice with experimental chronic uremia was analysed by autoradiographic methods. It was found that the physiological regeneration of the epithelium is impeded: A prolongation of the generation time of about 30% in the small and 55% in the large bowel can be observed. These changes of generation time are caused by a prolongation of the S-phase (small and large bowel) and of the G1-phase (large bowel). The retardation of the regeneration leads to a shortening of villi and crypts in all parts of the bowel.
    Notes: Zusammenfassung Um Aufschluß über den Entstehungsmechanismus urämischer Darmschäden zu gewinnen, wurde bei Mäusen mit einer experimentellen chronischen Urämie der Generationscyclus des Darmepithels autoradiographisch untersucht. Hierbei fand sich eine Hemmung der physiologischen Epithelregeneration auf Grund einer Verlängerung der Generationszeit um 30% im Dünndarm und um 55% im Dickdarm. Diese Generationszeitveränderungen beruhen auf einer Verlängerung der S-Phase (Dünn- und Dickdarm) und der G1-Phase (Dickdarm). Durch die Regenerationshemmung kommt es zu einer Zotten- bzw. Cryptenreduktion in allen Darmabschnitten.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 1303-1304 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We report on 46,XX true hermaphroditism and 46,XX maleness coexisting in the same pedigree, with maternal as well as paternal transmission of the disorder. Molecular genetic analysis showed that both hermaphrodites as well as the 46,XX male were negative for Y-chromosomal sequences. Thus, this pedigree is highly informative and allows the following conclusions: first, the maternal as well as paternal transmission of the disorder allows the possibility of an autosomal dominant as well as an X-chromosomal dominant mode of inheritance; second, testicular determination in the absence of Y-specific sequences in familial 46,XX true hermaphrodites as well as in 46,XX males seems to be due to the varying expression of the same genetic defect; and third, there is incomplete penetrance of the defect.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2307
    Keywords: Thyroid tumour ; Immunohistochemistry ; Keratin ; Thyroglobulin ; Differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 56 thyroid gland tumours and non neoplastic alterations were studied for keratin and thyroglobulin staining, using the indirect immunoperoxidase method on serial formalin fixed paraffin embedded sections. Papillary carcinomas showed a strong reaction with anti-keratin serum but a weak reaction with anti-thyroglobulin serum. Follicular adenomas and carcinomas showed virtually no reaction for keratin but a strong reaction for thyroglobulin. Undifferentiated and medullary carcinomas did not react with either antiserum, except for single cells in two undifferentiated carcinomas which reacted with anti-keratin serum. In nodular goiters, hyperplastic follicles showed little or no reaction with anti-keratin serum and strong reaction with anti-thyroglobulin serum. It is suggested that this virtually type-specific staining for keratin or thyroglobulin may be related to different degrees of cellular differentiation and organelle content in the tumour cells.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2307
    Keywords: Acromegaly ; Osteoporosis ; Collagen type II ; Lysyl hydroxylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although it is now 60 years after Erdheim's (1931) detailed description of vertebral alterations in severe acromegaly, it is still unclear whether osteoporosis is a consistent feature of acromegalic bone disease or not. We studied the vertebral trabecular bone of a 44-year-old woman who had suffered active acromegaly for more than 20 years, and compared it with 17 normal as well as 2 osteoporotic controls. Histomorphometry revealed a very low trabecular bone volume and thus documented the presence of osteoporosis. The mean trabecular plate thickness was strikingly increased in acromegaly (possibly caused in part by a low-dose fluoride treatment), whereas it was normal or reduced in the osteoporotic controls. The meticulous analysis showed islands of cartilaginous tissue in the core of the acromegalic trabeculae which were not present in any other sample. In these areas collagen II was detected by immunohistochemistry. Biochemical analysis revealed that collagen II accounted for 7% of the total collagenous matrix. The degree of hydroxylation of lysyl residues of collagen I was close to the average value of all control samples studied. Our data show that osteoporosis can occur in acromegaly and that it is characterized by unusual architectural and compositional features. These findings challenge the prevailing view that the matrix of osteoporotic bone always shows a normal composition.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 429 (1996), S. 139-147 
    ISSN: 1432-2307
    Keywords: HIV ; Parotid gland ; Lymphoepithelial cyst ; Lymphoepithelial lesion ; Sjögren disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whether lymphoepithelial cysts in the parotid glands in HIV-infected patients develop from pre-existing salivary gland inclusions in intraparotid lymph nodes or from a lymphoepithelial lesion of salivary parenchyma is unclear. To examine their pathogenesis we performed a histological and immunohistochemical study of salivary specimens from 100 AIDS patients in different disease stages. There is a continuous morphological spectrum of changes within the salivary parenchyma, starting with lymphoid stroma infiltration and evolving to characteristic lymphoepithelial duct lesions with a immunohistochemically proven basal cell proliferation and to fully developed ductal cysts. Involvement of myoepithelial cells — postulated in comparable Sjögren-associated duct lesions — is excluded immunohistochemically. Computer-assisted 3-D reconstructions confirm an association of the cysts with the intralobular duct system. Our study disproves the prevailing hypothesis, which suggests that the lymphoid cell compartment of HIV-associated lymphoepithelial cysts stems from pre-existing intraparotid lymph nodes. The results demonstrate that a secondary lymphatic infiltration of salivary parenchyma provokes a lymphoepithelial lesion of striated ducts with basal cell hyperplasia. The frequent progression to a multifocal cystic lymphoepithelial lesion may be supported by ductal compression through a high degree of lymphofollicular hyperplasia in early disease.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 418 (1991), S. 301-309 
    ISSN: 1432-2307
    Keywords: Flow cytometry ; Gastric cancer ; DNA-aneuploidy ; Prognosis ; Histological type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 125 gastric carcinomas the nuclear DNA content was determined by flow cytometry from formalin-fixed and paraffin-embedded tissue of surgical specimens. The carcinomas were of intestinal or mixed type (85), and diffuse type (40). DNA-aneuploidy was found in 46% of the intestinal type and in 42% of the mixed type, but only in 15% of the diffuse-type carcinomas (P〈0.01). The total rate of DNA-aneuploidy was 34%. Carcinomas localized in the cardia were more frequently DNA-aneuploid than tumours in other localizations (P〈0.01). DNA-aneuploid carcinomas had metastasized more frequently to regional lymph nodes (P〈0.05) whereas no correlations with tumour stage and cytological/histological grade were detected. In 94 patients follow-up data were available. DNA-aneuploidy was associated with a statistically significant poorer prognosis when compared to DNA-diploid tumours only in advanced gastric carcinomas with lymph node metastases (P=0.0488) and in the subgroup of advanced intestinal and mixed-type tumours (P=0.0289).
    Type of Medium: Electronic Resource
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