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  • 1
    ISSN: 1437-160X
    Keywords: Early rheumatoid arthritis ; IgA-alpha-1-antitrypsin complex ; Radiological deterioration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We followed the levels of serum IgA-alpha-1-antitrypsin (IgA-AT) complex in 37 patients with early rheumatoid arthritis (RA) during the first 3 years of the disease. The changes in IgA-AT were correlated with a radiological damage score (DS) of the hands assessed according to Larsen. At the onset of the disease, the IgA-AT serum concentration was significantly higher as compared to the control group (0.72±0.22 U vs 0.29±0.14 U, P〈0.01). The level significantly decreased during the 3-year observation period. The DS was significantly higher after 3 years. However, this difference was due to changes in only 11 patients; in 26 patients the DS was almost unchanged. In the group of 11 patients with radiological progression, the level of IgA-AT either remained high or increased significantly (0.95±0.18 U at the onset, 0.97±0.25 U after 3 years), whereas we observed a decrease in IgA-AT in 26 patients without radiological progression (0.63±0.16 U at the onset of the disease, 0.45±0.10 U after 3 years, P〈0.01). Moreover, a relationship between changes in IgA-AT serum level and radiological progression was shown (r=0.60, P〈0.01). Our studies suggested that the relationship between IgA-AT level and radiological progression of the disease should be considered. We cannot exclude the possibility that the constant high level of IgA-AT may cause worsening in bone erosions.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-160X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1437-160X
    Keywords: Key words Lupus erythematosus ; Cyclophosphamide ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the long-term effect of intravenous pulse cyclophosphamide (CY) on lymphocyte surface antigens in systemic lupus erythematosus (SLE) patients. Blood samples derived from 17 lupus erythematosus patients were analysed using two- and three-colour flow cytometry. During the CY therapy, the total number of T lymphocytes (CD3+) was reduced by 31.4%, B lymphocytes (CD19+) by 67.4% and NK cells (CD16+) by 27.4%. Six months after the end of the CY regimen, these values recovered to entry levels. At the onset of the study we observed increased percentages of CD3+ CD25+, CD3+ CD4– CD8–, CD4+ CD29+, CD19+ and CD19+ CD5+ cells. The CY treatment regimen decreased the CD3+ CD25+, CD3+ CD4– CD8–, CD19+ and CD19+ CD5+ cells, but increased the CD3+ CD8+ subpopulation. Taken together, a deficiency of CD8+ T cells associated with CD4+ CD29+ predominance may imply an immune regulatory imbalance leading to abnormal CD4+ cell activation and in consequence to autoimmunity. Depletion of CD19+ cells combined with an enlargement of CD8 cells as a result of CY therapy may reduce the enhanced immune response in SLE patients.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Alpha-1-Acid-Glycoprotein ; Synovial Fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microheterogeneity of alpha-1-acid glycoprotein was studied using affinity immunoelectrophoresis with concanavalin A as a ligand in the samples of serum and synovial fluid obtained at the same time from 22 patients with rheumatoid arthritis. Individuals with intercurrent infection or other illnesses were excluded from the study. The results were expressed as reactivity coefficient (RC). Disease activity was evaluated by Mallya-Mace Activity Score, Lansbury Joint Index and laboratory tests. In most of the studied samples the glycosylation pattern was similar, composed of a nonreactive variant and 2 reactive (the first and the second) with Con A variants. In seven samples of synovial fluid an extra third peak representative of the strongly reactive one with Con A fraction was observed. It was the cause of the remarkable elevation of AGP-RC. Moreover, the level of IgM and IgA RF was higher in the synovial fluid derived from these patients — with the presence of the third peak in AFF-EP with Con A — than in those without the considered fraction.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-9949
    Keywords: Early Rheumatoid Arthritis ; IgA-alpha-1-antitrypsin Complex ; Acute Phase Proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We followed the levels of serum IgA-alpha-1-antitrypsin complex (IgA-AT), C-reactive protein (CRP), alpha-1-acidglycoprotein (AGP), and alpha-1-antichymotrypsin (ACT) in twenty-seven early rheumatoid arthritis (RA) patients during the first three years of the disease duration. Fifteen patients were treated with methotrexate (MTX), twelve patients with NSAIDs only. The IgA-AT serum concentrations were significantly higher in RA patients as compared to the control group (0.72±0.39 U, vs. 0.27±0.15 U, p〈0.01). It decreased in almost all individuals (23 cases) during the observation. This decrease occurred in both MTX treated and untreated patients; however, it was statistically significant (p〈0.01) only in MTX treated patients. On average, the levels of ESR, CRP, AGP, and ACT were higher at the beginning of the disease as compared to healthy controls. After three years duration of the disease, a significant decrease in serum levels of all these markers of acute phase response was observed. At the onset of the disease, AGP and ACT reactivity coefficients were normal; after three years they dropped. We demonstrated an association between IgA-AT level and erythrocyte sedimentation rate. No relationships were shown between IgA-AT levels and APP serum concentrations and APP glycosylation patterns in RA patients treated with MTX. Since decrease in IgA-AT level does not correlate with decrease in APP, we can suppose that observed changes in IgA-AT concentration depend rather on direct action of MTX on the complex, than the changes in disease course. Besides gold salts, D-penicillamine, and sulphasalazine, methotrexate may also destroy covalent linkage between IgA and antitrypsin.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-9949
    Keywords: Systemic Lupus Erythematosus ; Rheumatoid Arthritis ; Interleukin-10 ; Interleukin-6 ; Acute Phase Proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We sought to investigate the influence of interleukin-10 (IL10) and IL-6 on the acute phase proteins (APP) in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10, IL-6, Creative protein (CRP), alpha-1-acid glycoprotein (AGP), and alpha1 antichymotrypsin (ACT) serum levels were determined in one hundred-eight patients (71 with SLE, 37 with RA). Quantification of the serum IL-10 level showed increased levels in SLE and RA patients as compared to healthy controls. Serum IL-6 level was found to be elevated in SLE and RA patients. A correlation between IL-10 and IL-6 serum level was found only in SLE. CRP and AGP serum levels were increased in RA as compared to controls, whereas in SLE only AGP was found elevated. A statistically significant correlation between IL-6 serum level and CRP, AGP and ACT was found only in RA. No correlation between IL-10 and serum level of CRP, AGP and ACT was established. Since IL-10 has a potent immunosuppressive activity, we expected it to be negatively correlated with APP levels. Surprisingly, IL-10 did not correlate with APP either in SLE or RA patients. However, the elevation of IL-10 serum levels in SLE and RA and the correlation between IL-10 and IL-6 in SLE may suggest that IL-10 may play a central role in inflammatory connective tissue diseases.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-160X
    Keywords: Key words Rheumatoid arthritis ; Radiological progression ; TNF-α gene polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was undertaken in order to investigate the relationship between tumor necrosis factor-α (TNF-α) gene polymorphism and the radiological progression of rheumatoid arthritis (RA) within the first 3-years of the disease. Sixty-eight RA patients (59 women and nine men) were observed for 3-years. TNF-α polymorphism analysis was performed in all patients. Radiographs of the hands were taken at the onset of study and after 3-years of follow-up. Radiographs were assessed according to the Larsen index (damage score and progression of damage score). We did not observe any correlation between TNF gene polymorphism and damage score or progression of damage score. The obtained data suggests that TNF-308 polymorphism cannot serve as an indicator of the disease course in RA patients.
    Type of Medium: Electronic Resource
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