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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 143 (1975), S. 113-118 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The three haploid yeast strains T2tmp1-3, T2tmp1-1, and T6tmp1-51 auxotrophic for 5′-dTMP differ in their requirement for thymidylate: 72, 16, and 3 μg 5′-dTMP/ml will restore optimal growth, respectively. Thymidylate low requirement in strain T2tmp1-1 and T6tmp1-51 is termed tlrA and tlrC, respectively. When the growth medium is made 5x10-4 M for 5′-dTMP only strain T6tmp1-51 is severely inhibited in RNA and DNA synthesis. This inhibition is reversible after removal of excessive 5′-dTMP. The inhibitory characteristic is in marked contrast to “thymineless death” due to the lack of 5′-dTMP in strain T6tmp1-51 where only DNA synthesis stops while RNA synthesis continues. The inhibitory effect of 5x10-4 M 5′-dTMP is not due to the 5′-dTMP auxotrophy but to the thymidylate low requiring character (tlrC) in strain T6tmp1-51. The arrest of RNA and DNA synthesis by high concentrations of exogenous 5′-dTMP suggests a regulatory role of either the monoor triphosphate on nucleoside or nucleotide biosynthesis in yeast.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 131 (1974), S. 351-358 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Cells of Saccharomyces cerevisiae strain 211-1atmp1-1 which are auxotrophic for 5′-dTMP exhibit “thymineless death” (TLD) when deprived of the nucleotide. After an initial lag of about one generation time cells lose viability in exponential fashion halving their titer every 90 min. Thymine and thymidine (100 μg/ml) cannot prevent TLD in the absence of 5′-dTMP. Although the cell titer is constant during 24 hrs of 5′-dTMP deprivation, the cell mass synthesized increases by a factor of six during this period. Budding is stopped and cells attain a swollen shape. Synthesis of RNA and protein does occur in cells deprived of 5'-dTMP, the rates of synthesis being significantly lower than those in the controls.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 117 (1984), S. 2452-2463 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Photochemistry of 1,3,5-TristyrylbenzeneDepending on the reaction conditions the irradiation of the title compound 1 yields the cyclophane 5, the pyrene derivative 6, or the polycondensed aromatic system 9. An X-ray analysis was performed for 5, representing a new type of cyclophane in which two benzene rings are bridged again by rings.
    Notes: In Abhängigkeit von den Reaktionsbedingungen erhält man bei der Belichtung der Titelverbindung 1 das Cyclophan 5, das Pyrenderivat 6 oder das polykondensierte aromatische System 9. Für den neuen Cyclophantyp 5, bei dem zwei Benzolringe selbst wieder durch Ringe verbrückt sind, wurde eine Röntgenstrukturanalyse durchgeführt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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