ISSN:
1432-1440
Keywords:
Myocardial infarction
;
Endothelin-1
;
Complications
;
Creatine kinase
;
Left ventricular function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Endothelin-1 concentrations were measured in peripheral venous blood samples from 42 patients with acute myocardial infarction. In patients with ischemic or hemodynamic complications (n = l1), endothelin-1 concentrations were significantly higher already on admission (P = 0.008) and remained significantly higher until day 6 after admission compared to patients with uncomplicated infarctions (n = 31; P = 0.035). There were no close correlations between peak concentrations of endothelin-1 and creatine kinase or creatine kinase isoenzyme MB mass in either group. Only in complicated patients did left ventricular ejection fraction correlate closely and inversely with peak endothelin-1 concentrations (r = −0.71; P = 0.03). Therefore, plasma endothelin-1 concentrations in patients with acute myocardial infarction patients may reflect states of markedly depressed cardiac performance and recurrent myocardial ischemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00184545
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