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  • 1
    Electronic Resource
    Electronic Resource
    Transient electric dichroism studies of nucleosomal particles (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 4525-4533 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00614a026
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  • 2
    Electronic Resource
    Electronic Resource
    Gallbladder perforation: Comparison of US findings with CT (1994)
    Springer
    Abdominal imaging 19 (1994), S. 239-242 
    Details
    ISSN: 1432-0509
    Keywords: Gallbladder perforation ; US, gallbladder perforation ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the ultrasound (US) findings of gallbladder (GB) perforation with computed tomography (CT) in 13 patients with GB perforation confirmed at surgery. The common findings of GB perforation were pericholecystic fluid collection and layering of GB wall on US, pericholecystic fluid collection, streaky omentum or mesentery, and GB wall defect on CT. Pericholecystic fluid collection, layering of GB wall, and cholelithiasis were similarly detected on US or CT. GB wall defect and/or bulging of the GB wall suggested a site of perforation was revealed in five patients (38.5%) on US and nine (69.2%) on CT. CT further disclosed the findings of streaky omentum or mesentery (84.6%). CT was superior to US for diagnosis of GB perforation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203516
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  • 3
    Electronic Resource
    Electronic Resource
    Intraperitoneal seeding from hepatoma (1994)
    Springer
    Abdominal imaging 19 (1994), S. 309-312 
    Details
    ISSN: 1432-0509
    Keywords: Liver ; hepatoma ; Intraperitoneal seeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report three cases of intraperitoneal seeding from hepatoma. Manifestation of intraperitoneal seeding from hepatoma were intraperitoneal masses (N = 2) and peritoneal thickening (N = 1). Main vascular feeder to intraperitoneal masses was omental branches of the gastroduodenal artery and/or the superior mesenteric artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198185
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  • 4
    Electronic Resource
    Electronic Resource
    Bromodeoxyuridine labeling study of intracranial meningiomas: proliferative potential and recurrence (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 311-317 
    Details
    ISSN: 1432-0533
    Keywords: Meningioma ; Bromodeoxyuridine ; Cell kinetics ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-six patients with intracranial meningiomas and two with hemangiopericytic variants received a 30-min intravenous infusion of bromodeoxyuridine (BrdUrd), 200 mg/m2, before tumor removal. Excised tumor specimens were stained by the indirect immunoperoxidase method to determine the BrdUrd labeling index (LI), or percentage of cells in DNA synthesis. The BrdUrd LI was 〈 1% in 63 (86.3%) of 73 nonmalignant meningiomas and 〈 1% in 20 (87%) of 23 malignant meningiomas. Of 23 malignant meningiomas 11 were recurrent tumors; 8 patients had recurrence 3 to 33 months after the study. The recurrence rate was 100% (five of five) in patients whose tumors had a BrdUrd LI 〉 5%, 44% (11 of 25) in those with a BrdUrd LI 1% to 5%, and 6.1% (4 of 66) in those with an LI 〈 1%. Thus, meningiomas with a BrdUrd LI 〉 1% may grow faster and recur more frequently. Among patients with malignant mengngiomas, the mean time to recurrence after the study was 7.5 months in those with a BrdUrd LI 〉 5% and 20.2 months for those with an LI 1% to 5%. The mean time to recurrence was 97.8 months in patients with nonmalignant meningiomas. Both hemangiopericytic variants were recurrent and showed LIs of 0.5% and 4.1%; the former tumor recurred 8 years after complete resection, while the latter recurred three times in 3.5 years. Thus, the proliferative potential of intracranial meningiomas as reflected by the BrdUrd LI appears to be a prognostic variable that can help to elucidate the biological behavior of individual meningiomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294650
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of sediment nitrogen-availability on carbon and nitrogen dynamics in the seagrass Thalassia testudinum (1999)
    Springer
    Marine biology 134 (1999), S. 217-226 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Variations in tissue carbon (C), nitrogen (N) content, and non-structural carbohydrate (NSC) reserves in the turtle grass Thalassia testudinum Banks ex König were examined in relation to changes in sediment-N availability in Corpus Christi Bay (CCB) and lower Laguna Madre (LLM), Texas, USA, from May to October 1997. Under natural conditions, sediment pore-water NH+ 4-concentrations were higher at CCB (100 μM) than at LLM (30 μM); this difference was reflected in a significantly higher leaf and rhizome N-content at CCB than at LLM. However, sediment NH+ 4-enrichment using a commercial fertilizer resulted in significantly higher tissue N-content relative to controls at both sites. N enrichment also influenced plant carbon metabolism, as reflected by distinct increases in leaf C-content at both sites. Significant decreases in rhizome NSC-content was recorded during the first two months of the experiment, suggesting that C was reallocated from rhizomes to leaves to support stimulated leaf growth at both sites. At LLM, leaf growth-rates increased and leaf turnover-time decreased as a result of sediment NH+ 4-enrichment. With respect to chlorophyll, concentrations did not change significantly at CCB, but increased steadily at LLM after the first month following fertilization. In general however, chlorophyll concentrations in control plots were significantly higher at CCB than that at LLM. These observations suggest that leaf function related to C-fixation is enhanced under higher sediment N conditions, as reflected in higher leaf growth-rates and increased blade chlorophyll-content. In contrast, under low-N conditions, below-ground tissue production is enhanced at the expense of the above-ground shoots and leaves, resulting in the high below: above-ground biomass ratios often observed in seagrass beds of oligotrophic environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050540
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat (1977)
    Springer
    Experimental brain research 29 (1977), S. 475-485 
    Details
    ISSN: 1432-1106
    Keywords: Deafferentation ; Bouton proliferation ; Dentate gyrus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative morphological study of the changes in the dentate gyrus molecular layer in response to the removal of perforant path afferents was made utilizing electron microscopic techniques. Alterations in 1. the population of remaining afferents, 2. glial cells, and 3. granule cell dendrites are reported. The major observation was an increase in intact bouton density in the region of denervation which began at 5 days post-lesion and continued through 11 days post-lesion, the longest post-lesion survival time studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236185
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  • 7
    Electronic Resource
    Electronic Resource
    Solitary maxillary central incisor and congenital nasal pyriform aperture stenosis (1997)
    Springer
    European journal of pediatrics 157 (1997), S. 39-44 
    Details
    ISSN: 1432-1076
    Keywords: Key words Solitary maxillary central incisor ; Holoprosencephaly ; Congenital nasal pyriform aperture Chromosome 18p- ; or ring(18) ; Stenosis ; Hypopituitarism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Solitary maxillary central incisor (SMCI) and congenital nasal pyriform aperture stenosis (CNPAS) have been reported as an isolated morphogenic defect or associated with pituitary deficiency, holoprosencephaly, ocular coloboma, or chromosomal abnormalities. We report two cases and analyse 40 cases of SMCI and 24 cases of CNPAS, including 15 cases of combined SMCI and CNPAS, obtained from the literature. Of the patients with SMCI, 69% had short stature, 48% growth hormone deficiency or hypopituitarism, 23% pituitary absence or hypoplasia, and 17% had del (18p-) or r(18). Of the patients with CNPAS, 63% had SMCI, 75% were short, 43% had hypopituitarism or growth hormone deficiency, 36% had pituitary or CNS anomaly, and 33% had del (18p), r(18), or del (13q). Conclusions Solitary maxillary central incisor and congenital nasal pyriform aperture stenosis can be a diagnostic clue to pituitary hypofunction, CNS, ophthalmological and cytogenic anomalies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050763
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  • 8
    Electronic Resource
    Electronic Resource
    A reproducible model of reversible, focal, neocortical ischemia in Sprague-Dawley rat (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 66-71 
    Details
    ISSN: 0942-0940
    Keywords: Reperfusion ; cerebral ischemia ; Sprague-Dawley rat ; middle cerebral artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A reproducible model of reversible, focal ischemia was developed for use with the normotensive, Sprague-Dawley rat. Blood flow to the left cerebral hemisphere was interrupted by occluding simultaneously the left middle cerebral artery and both carotid arteries (CCA). The arterial occlusion lasted for 1, 2 or 3 hours after which animals survived for 3 days. The volume of brain infarction was determined utilizing computer-assisted measurements of serial brain sections stained with triphenyltetrazolium. Tissue infarctions of variable size were observed following arterial occlusions which persisted 1 or 2 hours. In contrast, remarkably-consistent infarction size was obtained following a three hours period of occlusion. Tissue edema was also estimated by measuring the volumes of the two hemispheres and expressing these values as a ratio for each animal. The volume ratio was significantly greater in the 3 hour ischemic group, indicating the occurrence of edema in the infarcted hemisphere. These results demonstrate that reversible vascular occlusion in the normal, Sprague-Dawley rat results in consistent amounts of tissue infarction. This approach represents an attractive model system for studying the pathophysiological effects of transient, focal ischemia and for testing the effects of putative, therapeutic strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02001472
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  • 9
    Electronic Resource
    Electronic Resource
    Enhanced magnetic resonance imaging of the rat brain using a stereotaetic device with a small head coil: Technical note (1995)
    Springer
    Acta neurochirurgica 133 (1995), S. 87-92 
    Details
    ISSN: 0942-0940
    Keywords: MRI ; rat, brain ; stereotactic atlas ; Gamma Knife
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A stereotactic device (SDM) was developed for performing consistent magnetic resonance imaging (MRI) of the rat brain. The SDM was developed by adapting a radiofrequency transmit/receive head coil of 4.4 cm inner diameter (quadrature birdcage head coil), and utilizing partial acrylic construction for the positioning elements. The small head coil provides improved resolution and accuracy of the image, while the stereotactic holder permits repeatable and accurate imaging of identified brain structures. This system provides several advantages over existing experimental MRI devices. The SDM ensures that the head is always placed in the center of the coil in a uniform fashion. Standardized positioning of the skull optimizes image quality and provides a consistent orientation of the brain. In addition, a widely-utilized coordinate system described by Paxinos and Watson can be employed to assist in the identification of structures and to facilitate surgical planning. The SDM is compatible with a recently-developed stereotactic device for radiosurgery with the Gamma Knife, thus permitting the planning and performance of experimental radiosurgery using the same coordinate system. The SDM also provides the ability to perform MRI and radiosurgery at different times, thus avoiding the need for prolonged anesthesia during an experimental study. Finally, the SDM allows repeated MRI of the same, identifiable positions in the brain during longitudinal experimental studies. The utility of this device is demonstrated here by examining the time course of cerebral damage that evolved within a radiosurgical focus after gamma irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404955
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  • 10
    Electronic Resource
    Electronic Resource
    A stereotactic device for experimental Gamma Knife radiosurgery in rats (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 156-160 
    Details
    ISSN: 0942-0940
    Keywords: Gamma Knife ; radiosurgery ; rat ; stereotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A rat stereotactic device was designed for use in Gamma Knife radiosurgery. Experimental radiosurgical lesions were made in superficial and deep cerebral structures to verify the accuracy of the coordinate system, which is based on a standard rat stereotactic atlas. Calculated dosages were shown to be accurate utilizing thermoluminescence dosimetry. Two additional features of the device permit the surgical positioning and placement of electrodes, and postmortem slicing of the brain according to the same coordinate system. This new apparatus allows precise and repeatable gamma irradiation of the rat brain without the need for expensive and time-consuming imaging techniques. Studies of this type will provide a rapid means for examining the effects of radiosurgery on the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401844
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