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  • 1
    Electronic Resource
    Electronic Resource
    Individual and combined toxicity of some petroleum aromatics to the marine amphipod Elasmopus pectenicrus (1978)
    Springer
    Marine biology 48 (1978), S. 215-222 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Toxicity of 4 components of petroleum oils to the marine amphipod Elasmopus pectenicrus (Bate) has been assessed. Two ephemeral aromatic hydrocarbons, naphthalene (A) and 1, 2, 4-trimethylbenzene (B) were more toxic than two persistent aromatics, o-cresol (C) and o-toluidine (D). The acute toxicity concentrations obtained for individual aromatic compounds were always greater than the actual concentrations found in the water-soluble fractions (WSF) of fuel oils. Results from mixtures of 2 or more components indicated that the LC50 levels were primarily determined by the more toxic substances, A and B. Naphthalene and 1, 2, 4-trimethylbenzene became more toxic to the E. pectenicrus when present in a mixture of more than 2 components, and the toxicity increased with increasing numbers of components present. Synergistic effects, therefore, possibly occur in the whole WSF. No antagonistic effects were observed among the 4 petroleum aromatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397147
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  • 2
    Electronic Resource
    Electronic Resource
    NOS-like immunoreactive neurons express GABA-like immunoreactivity in rabbit and rat retinae (1998)
    Springer
    Experimental brain research 120 (1998), S. 109-113 
    Details
    ISSN: 1432-1106
    Keywords: Key words Nitric oxide synthase ; GABA ; Retina ; Rabbit ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In rabbit and rat retinae, wholemounted preparations and 40 μm thick vibratome sections were processed for nitric oxide synthase (NOS) immunoreactivity and consecutive semithin sections were immunostained with anti-NOS and anti-GABA antisera, respectively. Two types of NOS-labelled amacrine cells were identified: type 1 cells with larger somata were intensely stained, and type 2 cells with smaller somata were weakly stained. A few displaced amacrine cells also showed NOS-like immunoreactivity. All these NOS-like immunoreactive neurons also expressed GABA-like immunoreactivity. Thus, nitric-oxide-containing neurons might constitute a subpopulation of GABAergic neurons in rabbit and rat retinae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050383
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  • 3
    Electronic Resource
    Electronic Resource
    Reaction of Müller cells after increased intraocular pressure in the rat retina (1998)
    Springer
    Experimental brain research 121 (1998), S. 419-424 
    Details
    ISSN: 1432-1106
    Keywords: Key words Glial fibrillary acidic protein ; Müller cell ; Increased intraocular pressure ; Retina ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Using light microscopy and immunocytochemistry, we investigated the morphological changes of retinal tissues and the reaction of Müller cells in the ischemic rat retina induced by increasing intraocular pressure. At early stages (from 1 h to 24 h after reperfusion), cells in the ganglion cell layer and in the inner nuclear layer showed some degenerative changes, but at later stages (from 72 h to 4 weeks) marked degenerative changes occurred in the outer nuclear layer (ONL). At 4 weeks after reperfusion, the ONL was reduced to 1 or 2 cell layers. Immunoreactivity for glial fibrillary acidic protein (GFAP) appeared in the endfeet and distal processes of Müller cells as of 1 h after reperfusion. GFAP immunoreactivity in Müller cells increased up to 2 weeks and then decreased at 4 weeks after reperfusion. Our findings suggest that Müller cells are involved in the pathophysiology of retinal ischemia through the expression of GFAP. The degree of GFAP expression in Müller cells closely correlated with that of the degeneration of retinal neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050476
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  • 4
    Electronic Resource
    Electronic Resource
    The birthdates of GABA-immunoreactive amacrine cells in the rat retina (1999)
    Springer
    Experimental brain research 128 (1999), S. 309-314 
    Details
    ISSN: 1432-1106
    Keywords: Key words GABA ; Bromodeoxyuridine ; Proliferation ; Immunohistochemistry ; Retina ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The birthdates of GABAergic amacrine cells in the rat retina were investigated by immunocytochemistry using anti-GABA and anti-bromodeoxyuridine (BrdU) antisera. The ratio of co-localization of GABA to BrdU increased gradually from embryonic-day 13 (E13) and showed a peak value on E18 in the central retina and on E20 in the periphery. After birth, until postnatal-day 3 (P3), a few co-localized cells were observed in the inner nuclear layer (INL). However, in the peripheral retina, co-localized cells were observed in the INL and ganglion cell layer until P5. Our results suggest that the birthdates of GABA-immunoreactive cells vary, depending on cell-type and that there is a temporal lag in the GABA-immunoreactive cell production in the peripheral retina relative to the central retina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050851
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  • 5
    Electronic Resource
    Electronic Resource
    The Application of Transcranial Doppler Sonography in Patients with Chronic Subdural Haematoma (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 835-839 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Cerebral blood flow velocity (CBFv); middle cerebral artery (MCA); chronic subdural haematoma (CSDH).
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The aim of this study was to evaluate the haemodynamic changes of the middle cerebral artery (MCA) and their clinical significance before and after surgical aspiration in patients with chronic subdural haematoma (CSDH).  Nineteen patients with CSDH (17 unilateral and 2 bilateral) received transcranial Doppler sonography (TCD) examinations for cerebral blood flow velocity (CBFv) of the MCA prior to and 5 days after neurosurgical treatment. A total of 21 lesion and 10 non-lesion hemispheres were included. Cranial computerized tomography (CT) and clinical assessments were performed before and 3 months following surgery.  The preoperative TCD study revealed that the lesion hemisphere had a modest decrease in CBFv in the MCA as compared to the non-lesion hemisphere. Postoperatively, the CBFv significantly improved in the lesion hemisphere, but not in the non-lesion hemisphere, compared to the preoperative data (P〈0.005). The improvement in CBFv showed no significant correlation with brain shift and haematoma volume of the initial cranial CT. Additionally, two patients, who were proved to have a postoperative complication of subdural pneumocephalus, failed to attend follow-up examinations of TCD.  Our results support TCD as an alternative follow-up examination for patients with CSDH, although it may not be sensitive enough as a preoperative screening tool. Postoperatively, improvements in the CBFv of the lesion hemisphere are characteristic. An unexplained difficulty of accessing cerebral basal arteries in follow-up TCD examinations should suggest pneumocephalus in the primary differential diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050384
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  • 6
    Electronic Resource
    Electronic Resource
    Resonance Raman studies on 8-mercaptoriboflavin
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 215 (1982), S. 22-27 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(82)90274-0
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  • 7
    Electronic Resource
    Electronic Resource
    Evidence for elevation of cytochrome P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administration
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 186 (1992), S. 846-853 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(92)90823-4
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of rutin and harmaline on rat reflux oesophagitis (2002)
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    Details
    ISSN: 1474-8673
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Chemistry and Pharmacology , Medicine
    Notes: 1 This study was aimed at evaluating the effect of rutin and harmaline (1-methyl-7-methoxy-3,4-dihydro-β-carboline) on the development of the surgically induced reflux oesophagitis, on gastric secretion, lipid peroxidation, polymorphonucleocytes (PMNs) accumulation, superoxide and hydroxyl radical production in PMNs, cytokine [interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α)] production in blood and [Ca2+]i mobilization in PMNs. 2 Rutin and harmaline significantly prevented the development of reflux oesophagitis and gastric secretion. Treatments of oesophagitis rats with rutin and harmaline inhibited lipid peroxidation, and myeloperoxidase (MPO) in the oesophagus in comparison with untreated rats. 3 Superoxide anion and hydrogen peroxide production in 1 μm formylmethionylleucylphenylalanine (fMLP)- or 0.1 μg ml−1N-phorbol 12-myristate 13-acetate (PMA)-activated PMNs was inhibited by rutin and harmaline in a dose-dependent fashion. Rutin and harmaline effectively scavenged the hydroxyl radical and hydrogen peroxide. Treatments of oesophagitis rats with rutin and harmaline inhibited IL-1β production in the oesophagus in comparison with untreated rats, but TNF-α production was not affected by rutin and harmaline. The fMLP-induced elevation of [Ca2+]i was inhibited by rutin. 4 The results of this study suggest that rutin and harmaline may have beneficial protective effects against reflux oesophagitis by the inhibition of gastric acid secretion, oxidative stress, inflammatory cytokine production (i.e. IL-1β), and intracellular calcium mobilization in PMNs in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1474-8673.2002.00241.x
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  • 9
    Electronic Resource
    Electronic Resource
    Differential expression of phospholipase D1 in the developing retina (2002)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 15 (2002), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Expression patterns of phospholipase D1 (PLD1) in the developing rat retina were investigated using immunocytochemistry and Western blot analysis and compared with the expression patterns of glutamine synthetase. PLD1 immunoreactivity appeared first in a few neuroblasts in the middle of the mantle zone of the primitive retina by embryonic (E) day 13. PLD1-immunoreactive primitive ganglion cells were characterized in the ganglion cell layer by E17. Faint immunoreactivity at E17 profiled radially orientated cells and this pattern appeared up to postnatal (P) day 7. In the ganglion cell layer at P3, displaced amacrine cells and ganglion cells were classified. At P5, presumptive horizontal cells and amacrine cells were identified. By P7, a thin outermost layer of newly formed segments of the photoreceptor cells was also PLD1 immunoreactive. PLD1 immunoreactivity at P8 was limited to radial Müller cells and the outer segment layer of the photoreceptor cells, and the expression pattern was conserved to adulthood. Western blot analysis showed relatively high amounts of PLD1 protein at E17 and P3, a decrease at P7, and moderate amounts from P8 onward. Co-expression of PLD1 with glutamine synthetase in the retina appeared first after birth in differentiating neurons and in Müller cells by P8; thereafter the pattern was maintained. The expression pattern of the PLD1 during development of the retina suggests that PLD1 plays important roles in glutamate-associated differentiation of both specific neurons and radial glial cells, and in glutamate-mediated cellular signalling in Müller cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2002.01939.x
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  • 10
    Electronic Resource
    Electronic Resource
    A computer-controlled apparatus for performing high-resolution adsorption isotherms (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 1886-1890 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A high precision, computer-controlled adsorption isotherm apparatus has been constructed and used to investigate a variety of physisorbed systems. Suitable for absolute measurements, this apparatus features good vapor pressure resolution and outstanding temperature stability. The hallmark of the apparatus, however, is the graphical computer interface, written using the popular LABVIEW package, which offers a flexibility and ease-of-use not achieved in previous automated systems. This article will demonstrate the quality of data obtainable with this system, as well as the simplicity of operation afforded by the graphical interface. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146993
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