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  • 1
    Electronic Resource
    Electronic Resource
    Decreased plasma membrane fluidity of peripheral blood lymphocytes after diethyldithiocarbamate (DTC) therapy in HIV-infected patients (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 521-523 
    Details
    ISSN: 1432-1041
    Keywords: diethyldithiocarbamate (DTC) ; human immunodeficiency virus (HIV) ; plasma membrane fluidity ; fluorescence anisotropy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In seeking the putative mechanism of action of diethyldithiocarbamate (DTC) on the immune status of HIV infected patients, the plasma membrane fluidity of peripheral blood lymphocytes (PBL) from DTC-treated and untreated patients (CDC III-IVc1) was determined. Anisotropy values of the fluorescent probe 6-(9-anthroyloxy) stearic acid were increased in DTC-treated patients (0.175 vs 0.161), indicating decreased PBL plasma membrane fluidity. The membrane rigidifying effect was significantly greater 4 h after i.v. drug administration (0.185 in treated patients). As the membrane fluidity and the function of membrane embedded antigen are interdependent, it is possible that alterations in biophysical and/or biochemical properties of membranes may account for the beneficial effect of DTC on the immune function and clinical status of HIV infected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558135
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  • 2
    Electronic Resource
    Electronic Resource
    Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 14 (1993), S. 573-581 
    Details
    ISSN: 0891-5849
    Keywords: Animal model ; Cigarette smoke ; Free radicals ; Hamster ; Intravital microscopy ; Leukocyte/endothelium interaction ; Microcirculation ; Superoxide dismutase ; Tobacco
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90138-K
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  • 3
    Electronic Resource
    Electronic Resource
    Long-Term Evaluation of a Rat Model of Chronic Cholangitis Resembling Human Primary Sclerosing Cholangitis (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 58 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder with a presumed autoimmune aetiopathogenesis. We have recently described a novel organ-specific rat model of fibrosing cholangitis induced by intrabiliary administration of the hapten-reagent 2,4,6-trinitrobenzenesulfonic acid (TNBS) with similarities to human PSC. In the present report, we have evaluated the long-term outcome of TNBS-induced cholangitis in this model. Mild stenosis of the common bile duct of female Lewis rats (n = 18) was achieved by subtotal ligation and cholangitis induced by TNBS injection (50 mg/kg) into the dilated bile duct after a second laparotomy. After 8 and 12 months, we found no evidence of cholangitis in serum chemistry or histology or retrograde cholangiography of TNBS-treated rats. Antineutrophil cytoplasmic antibodies were positive in 75% of animals but were not predictive of liver damage. Tumour necrosis factor-α levels were not elevated in serum or in mononuclear spleen cell supernatants. Our findings suggest that a single initial insult is not sufficient to trigger chronic progressive inflammation. Rather, perpetuation of inflammation probably requires additional stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2003.01335.x
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  • 4
    Electronic Resource
    Electronic Resource
    Role of oxygen radicals in the microcirculatory manifestations of postischemic injury (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 1050-1055 
    Details
    ISSN: 1432-1440
    Keywords: Ischemia-reperfusion ; Microcirculation ; Oxygen radicals ; Chemoattractants ; PMN-endothelium interaction ; No-reflow ; Reflow-paradox
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reperfusion after transient tissue ischemia constitutes an irrevocable need to preserve tissue viability. However, release of prolonged ischemia will either result in failure of the microcirculation to reperfusion (no-reflow) and thus the prolongation of hypoxia, or in restoration of blood flow resulting in reoxygenation of the inflicted tissue. While ischemia damages the tissue primarily through hypoxia-induced depletion of energy stores, reoxygenation paradoxically contributes to tissue damage through the formation of oxygen radicals, the release of chemoattractant mediators (TNF, IL-1, LTB4), and the activation of circulating polymorphonuclear leukocytes (PMNs). Through the action of chemoattractant mediators and the upregulation of leukocytic (CD11/CD18) and endothelial adhesion receptors (ICAM, GMP-140), activated PMNs adhere to the endothelium, release further chemoattractants and oxygen radicals and undertain a vicious circle, which will ultimately result in further tissue damage. Both theno-reflow phenomenon and the events initiated by reflow — termed herein as thereflow-paradox — contribute to the failure of the nutritive microvascular perfusion and loss of tissue viability following ischemia and reperfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01645157
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  • 5
    Electronic Resource
    Electronic Resource
    Role of oxygen radicals in the microcirculatory manifestations of postischemic injury (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 1185-1185 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01815436
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  • 6
    Electronic Resource
    Electronic Resource
    Diphenylhydantoin (DPH) Blocks HIV Receptor on T-Lymphocyte Surface (1987)
    Springer
    Annals of hematology 55 (1987), S. 524-524 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320226
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  • 7
    Electronic Resource
    Electronic Resource
    Diphenylhydantoin (DPH) blocks HIV-receptor on T-lymphocyte surface (1986)
    Springer
    Annals of hematology 53 (1986), S. 447-450 
    Details
    ISSN: 1432-0584
    Keywords: Diphenylhydantoin ; T-Lymphocyte ; HIV-Receptor ; Radioactive labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous reports have shown the capacity of diphenylhydantoin (DPH) to attach to the membranes of lymphatic cells as a hapten and thus exert an unspecific influence on their ability to express certain recognition molecules. This led us to the hypothesis, that DPH might as well serve to manipulate the t-helperlymphocytes in a way that the mode of infection of these cells by the HIV might be blocked. In order to verify this hypothesis, we exposed normal control lymphocytes as well as lymphocytes from DPH-treated patients (3×100–150 mg DPH/day, Phenhydan®, for a minimum of 10 days) to radioactively labeled HIV (125I). Remaining radioactivity was assessed using a gamma-counter and measured 64.000–92.000 counts/min (n=24, mean 80.000) for the control lymphocytes, while remaining radioactivity for the DPH-treated lymphocytes ranged between 2000 and 7000 counts/min (n=24, mean 4.000, p〈0.001). These results and similar experiments obtained with FITC-labeled HIV led us to the conclusion that DPH inhibits HIV recognition of T-lymphocytes and therefore might be used in therapy and prophylaxis of AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320308
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  • 8
    Electronic Resource
    Electronic Resource
    Endovascular catheter-delivered photodynamic therapy in an experimental response to injury model (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 310-319 
    Details
    ISSN: 1435-1803
    Keywords: Restenosis ; photo-dynamic therapy ; angioplasty ; local drug delivery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background The effectiveness of local endovascular photodynamic therapy (PDT) in preventing tissue hyperplasia was evaluated in a vascular injury model. Methods Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries (n=180). Animals (n=72) were randomly allocated to unidirectional injury only (Group 1), injury followed by drug delivery of photosensitizer with a porous balloon (Group 2), or by local exposure to monochromatic light (Group 3). In Group 4, injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (PDT). Up to 21 days after treatment, all experimental vessels were excised, fixed and processed for histology, immunohistochemistry and transmission electron microscopy. Results After vascular injury an inflammatory and myoproliferative response was observed in Groups 1, 2 and 3 (mean tissue hyperplasia/media ratio 1.0±0.5 at 21 days; area tissue hyperplasia: 1.57±0.9 mm2). Proliferation in injured vascular segments (Group 1–3) reached a maximum at 7 days, with 6%. Only in Group 4, injury followed by photodynamic therapy, was there no significant vascular response (mean tissue hyperplasia/media ratio 0.3±0.2; area tissue hyperplasia: 0.1±0.05 mm2 p〈0.001, proliferating cells 0.3%). Conclusion Vascular response after unidirectional injury was suppressed only by endovascular photodynamic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788943
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  • 9
    Electronic Resource
    Electronic Resource
    Endovascular catheter-delivered photodynamic therapy in an experimental response to injury model (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 310-319 
    Details
    ISSN: 1435-1803
    Keywords: Key words Restenosis – photodynamic therapy – angioplasty – local drug delivery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The effectiveness of local endovascular photodynamic therapy (PDT) in preventing tissue hyperplasia was evaluated in a vascular injury model. Methods: Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries (n = 180). Animals (n = 72) were randomly allocated to unidirectional injury only (Group 1), injury followed by drug delivery of photosensitizer with a porous balloon (Group 2), or by local exposure to monochromatic light (Group 3). In Group 4, injury was followed by local drug delivery of photosensitzier and subsequent exposure to light (PDT). Up to 21 days after treatment, all experimental vessels were excised, fixed and processed for histology, immunohistochemistry and transmission electron microscopy. Results: After vascular injury an inflammatory and myoproliferative response was observed in Groups 1, 2 and 3 (mean tissue hyperplasia/media ratio 1.0 ± 0.5 at 21 days; area tissue hyperplasia: 1.57 ± 0.9 mm2). Proliferation in injured vascular segments (Group 1-3) reached a miximum at 7 days, with 6 %. Only in Group 4, after injury followed by photodynamic therapy, was there no significant vascular response (mean tissue hyperplasia/media ratio 0.3 ± 0.2; area tissue hyperplasia: 0.1 ± 0.05 mm2 p 〉 0.001, proliferating cells 0.3 %). Conclusion: Vascular response after unidirectional injury was suppressed only by endovascular photodynamic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788943
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