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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 1163-1169 
    ISSN: 1432-1440
    Keywords: Cholesterol gallstones ; Biliary lipid secretion ; Deoxycholic acid ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measurements of biliary lipid secretion rates were performed in 14 non-obese patients with radiolucent gallstones (9 females, 5 males; mean age 48 years; mean body weight 65 kg) and in 14 healthy male volunteers (mean age 26 years, mean body weight 74 kg). The results in the gallstone patients differ in several respect from those obtained in the volunteers. Molar percentage of cholesterol was higher (5.8 versus 5.0 mol%;P〈0.05) and molar percentage of bile acids lower (73.8 versus 76.9 mol%;P〈0.05) in the gallstone patients. However, these changes were not followed by notable differences in cholesterol saturation of bile (94% vs 88%). Generally, hepatic secretion rates of cholesterol were significantly elevated in the gallstone patients (55 vs 46 mg/h;P〈0.05) whereas outputs of bile acids and phospholipids did not differ between the two groups. Although patients with cholesterol gallstones tended to have a lower percentage of chenodeoxycholic acid (38 versus 42 mol%) and increased deoxycholic acid (23 versus 16 mol%) in their bile, these differences were not significant. Nevertheless, in patients with cholesterol gallstones a significant positive correlation between deoxycholic acid secretion and cholesterol output was observed. For the whole group of patients and volunteers a positive correlation between age and cholesterol secretion could be demonstrated. The higher hepatic cholesterol secretion in gallstone patients seems not be due to differences in body weight, but rather to the older age of the patients. These results suggest that age itself or age-related changes in deoxycholic acid metabolism contributes to biliary cholesterol output in non-obese patients with cholesterol gallstones.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 279-281 
    ISSN: 1432-1440
    Keywords: Metronidazole ; Bile acids ; Cholesterol absorption ; Serum cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five patients with Crohn's disease long-term therapy with metronidazole (400 mg b.i.d.) was followed by a significant reduction of total serum cholesterol from 179 mg/dl to 156 mg/dl, 134 mg/dl, and 143 mg/dl, after 2–4 months, 6 months, and 9–12 months, respectively. Lipoprotein analysis before and after 3 weeks of administration of metronidazol (400 mg/day) to five normolipemic volunteers revealed that LDL-cholesterol was reduced by 21% (P〈0.05), whereas HDL-cholesterol remained unchanged. Biliary secretion of cholesterol and bile acids were reduced by 13% and 20% (P〈0.05), respectively, which might suggest a decreased sterol synthesis. The amount and percentage of intestinal cholesterol absorption were decreased by 33% and 22% (P〈0.05). Thus, a possible decrease in sterol synthesis and a reduction of cholesterol absorption might be responsible for the serum-cholesterol-lowering effect of metronidazole. However, caution should be taken when considering metronidazole for long-term treatment of patients with hypercholesterolemia due to possible side effects.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Gallstones ; Bile ; Nucleation time ; Cholesterol crystals ; Terpenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with cholesterol gallstones referred to elective cholecystectomy were randomly assigned prior to operation to no treatment (n=14), treatment with one capsule t.d.s. (n=12) or two capsules t.d.s. (n=11) of a terpene mixture (Rowachol). Patients with pigment stones (n=7) or no biliary tract disease (n=5) were also studied. Lipid composition, presence of cholesterol monohydrate crystals, and nucleation time were determined in galbladder bile aspirated during surgery. Cholesterol saturation was similar in the different groups. Crystals were present in all cholesterol gallstone patients without treatment and in none of the controls. In one of the patients treated with one capsule and four of the patients treated with two capsules crystals could not be detected. The terpenes prolonged nucleation time from 2.8 to 5.8 days (one capsule;P〈0.05) and to 9.5 days (two capsules;P〈0.001), respectively; but nucleation did not occur in seven controls. Although the mechanism by which the terpene mixture inhibits the formation of cholesterol crystals in bile was not determined, the findings suggest that the terpene mixture might be a useful agent for a clinical trial to test whether they will prevent recurrence of gallstones after medical dissolution.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 35-40 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Gallstones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biliary lipid composition, standard liver function tests, serum lipids and faecal fat excretion were studied in 15 children with chronic intrahepatic cholestasis (severe intrahepatic cholestasis, n=6; paucity of intralobular bile ducts, n=4; benign recurrent cholestasis, n=5) and compared to 15 children without gastrointestinal diseases. Severe and benign intrahepatic cholestasis were associated with normal or moderately elevated serum lipids. Biliary lipid concentrations were extremely reduced, bile acid concentrations were below the critical micellar concentration. This may account for the high incidence of gallstone formation in these patients. Remission periods in patients with benign recurrent cholestasis were not followed by complete normalisation of biliary lipid concentrations, indicating a primary defect in hepatic excretory function. Children with paucity of intralobular bile ducts showed markedly increased serum lipids, but only a two-fold reduction in biliary lipid concentrations. Cholic acid was the predominant bile acid in bile of all cholestatic children even during remission. Neither increased levels of monohydroxy bile acids nor unusual bile acids could be identified in notable amounts.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 143 (1984), S. 41-44 
    ISSN: 1432-1076
    Keywords: Chronic intrahepatic cholestasis ; Biliary lipid composition ; Bile acids ; Phenobarbital
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of phenobarbital (5.4–7.5 mg/kg body weight) for 14 days were studied in four children with severe intrahepatic cholestasis (group I) and in four with a syndromatic type of paucity of intralobular bile ducts (group II). Phenobarbital administration resulted in a moderate improvement of pruritus in all patients. There was a significant decrease of bilirubin in serum (group I: from 4.8 to 2.7 mg/dl; group II: from 6.1 to 2.1 mg/dl); total bile acids (group I: from 416 to 337 μmol/l; group II: from 156 to 123 μmol/l) and cholesterol (group I: from 248 to 207 mg/dl; group II: from 351 to 292 mg/dl). Alkaline phosphatase activity increased from 929 to 1126 U/l in group I and from 1751 to 2360 U/l in group II. SGOT and SGPT activities remained unchanged in both groups. In group I total biliary lipid concentration and bile acid output increased from 0.09 to 0.17 g/dl and from 3.9 to 7.2 μmol/kg per 30 min, respectively. Molar percentages of cholesterol, phospholipids and bile acids in bile remained unchanged. In group II total lipid concentrations and bile acid output increased from 1.62 to 2.0 g/dl and from 27.8 to 39.1 μmol/kg per 30 min, respectively. The molar percentage of cholesterol decreased from 5.6 to 3.5 mol%. The present results indicate that short term administration of phenobarbital has only minimal effects on biliary lipid metabolism in children with chronic intrahepatic cholestasis.
    Type of Medium: Electronic Resource
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