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  • 1
    Electronic Resource
    Electronic Resource
    Acute jejunal ileus in intestinal lymphangiectasia (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 568-571 
    Details
    ISSN: 1432-1440
    Keywords: Intestinal lymphangiectasia ; Proteinlosing enteropathy ; Ileus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 26-year-old patient presented with epigastric pain of sudden onset and severe puffy swelling of both legs and forearms. An irregularly shaped nodular filling defect on selective jejunal films, severe hypoproteinemia, low IgG concentration, and lymphopenia were suggestive of primary intestinal lymphangiectasia with protein-losing enteropathy, and the patient was placed on a low-fat diet with medium-chain triglycerides. This initially improved his condition, but some weeks later he developed obstructive ileus of the small intestine. On laparotomy yellowish to whitish deposits were found to be present in some segments of the small intestine and a fist-sized mass 100 cm distal to the duodenojejunal flexure was resected without complications. Histologically, the submucosal lymphatics were dilated, and the jejunal wall showed extensive pseudocystic, intramural submucosal lymph edema with secondary bleeding and tight stenosis of the jejunal lumen. During the 14-month follow-up time after discharge the patient has been asymptomatic and working, on no treatment other than a low-fat diet with medium-chain triglycerides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208483
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  • 2
    Electronic Resource
    Electronic Resource
    Plasmapheresis in the management of psoriasis (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 330-331 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis vulgaris ; Plasmapheresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509092
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  • 3
    Electronic Resource
    Electronic Resource
    Indication of doxorubicin cardiotoxicity by impairment of 131I-pIPPA utilization (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. S32 
    Details
    ISSN: 1619-7089
    Keywords: I-131-p-iodo-phenylpentadecanoic acid ; Doxorubicin ; Cardiotoxicity ; Myocardial fatty acid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was designed to evaluate if doxorubicin (D) can impair myocardial fatty acid utilization. To this end we studied the myocardial utilization of 131I-pIPPA in untreated (Co, n=6) and D (20 mg/kg intraperitoneal) treated rats. D was given 24 h (24 D, n=6) and 48 hours (48 D, n=6) before tracer administration. One min after i.v. 131I-pIPPA (50 μCi) injection, the hearts were rapidly removed, frozen in liquid nitrogen, weighed, and counted. Following lipid extraction of homogenized heart extracts 131 I radioactivity distribution was analyzed by thin-layer chromatography (TLC). In additional rat experiments, high energy phosphates (12 rats/group) and carnitine (20 rats/group) were determined enzymatically in heart extracts. The mean pIPPA uptake in rat heart (%dose/g) was 2.49 in Co, 1.74 in 24 D, and 2.36 in 48 D rats. Usually five peaks were separated by TLC, that with a mean Rf value of 0.92 corresponding to 131I-pIPPA, the remaining four representing catabolites of pIPPA metabolism. The mean relative amount of unmetabolized 131I-pIPPA as compared to the sum of 131I-pIPPA catabolites was less in Co than in 24 D or 48 D rats (P〈0.05) ( $$\bar x$$ : 46.5% vs 72.4% vs 59.4%, respectively). The mean carnitine content of heart extracts was higher in Co (0.55 μM/g) than in D treated rats (24 D, 0.42 μM/g; 48 D, 0.46 μM/g) P〈0.05). The total amount of higher energy phosphates was not different between the groups. However the mean ATP/AMP ratio was higher in Co (35.9) than in 24 D (22.3) or 48 D (27.1) rats (P〈0.05). We conclude that D therapy is accompanied by a partial reversible impairment in myocardial pIPPA utilization, possibly mediated by carnitine deficiency. Thus, 131I-pIPPA might be useful in patients on D therapy to evaluate eventual D-induced effects on myocardial fatty acid utilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258100
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  • 4
    Electronic Resource
    Electronic Resource
    Indication of reduced doxorubicin-induced cardiac toxicity by additional treatment with antioxidative substances (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 62-64 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The influence of antioxidative substances on doxorubicin-induced cardiac toxicity was studied in C 57 BL mice. Tocopherol (500 mg/kg), glutathione (1000 mg/kg), cysteamine (15 mg/kg) and L-cysteine (1000 mg/kg), injected i.p. 24 h before doxorubicin treatment (15 mg/kg i.p.) were able to reduce malonaldehyde production in cardiac tissues significantly. SH-containing substances with high reducing activity, such as vitamin E, could be a useful tool in clinical trials to prevent doxorubicin induced cardiac damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960629
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  • 5
    Electronic Resource
    Electronic Resource
    Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 1015-1017 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 μg/100 g of cyclic somatostatin and 4 μg/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 μg/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines. *** DIRECT SUPPORT *** A2025117 00011
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971812
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  • 6
    Electronic Resource
    Electronic Resource
    Pamidronat in der Behandlung der tumorassoziierten Hypercalcämie (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 690-695 
    Details
    ISSN: 1432-1440
    Keywords: Cancer-associated hypercalcemia ; Bisphosphonate ; Pamidronate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After a 48-hour rehydration period 28 of 31 patients with cancer-associated hypercalcemia (serum calcium ≥2.8 mmol/1) were treated intravenously with the bisphosphonate pamidronate. In three patients fluid repletion with 0.9% saline solution had already normalized serum calcium levels. Pamidronate was given in a single infusion on day 0, the dose of pamidronate adapted to the severity of hypercalcemia. If the serum calcium concentration was ≥2.8 mmol/1 on day 3, application of pamidronate was repeated. In all patients normocalcemia was restored; mean serum calcium decreased from 3.2±0.35 on day 0 to 2.15±0.32 on day 12. Hypercalcemia recurred in 11 patients, seven of these underwent pamidronate treatment according to the same therapeutical regimen. Normal calcium levels were attained in five cases. Side effects were of minor gravity:brief hyperthermia occurred in four patients and transient, asymptomatic hypocalcemia was noticed in nine cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649438
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  • 7
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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  • 8
    Electronic Resource
    Electronic Resource
    Noninvasive methods for the early detection of doxorubicin-induced cardiomyopathy (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 136-142 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin cardiomyopathy ; Systolic time intervals ; Radionuclide angiography ; Therapeutic risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ninety-eight female patients (mean age 54 years) who underwent doxorubicin therapy because of metastatic breast cancer were submitted to radionuclide angiography at rest. Left ventricular ejection fractions (LVEFs) were found to decrease significantly with the increasing cumulative doxorubicin dosage. Patients with prior local radiotherapy showed lower LVEFs at the same dosage level than nonirradiated patients, but the difference was not statistically significant. In a further study, 52 patients (mean age 56 years) were followed up regularly for their history and systolic time intervals prior to each doxorubicin treatment course. Before starting treatment, LVEF values were normal in all cases. Fifteen of these patients complained of dyspnea at some time during the treatment period before the critical cumulative dosage level of 550 mg/m2 was reached. Nine of these 15 patients showed an increase of the PEPI:LVETI ratio (≧0.40) and 12 patients a decrease of the LVEF values at rest at the same time. The rest of the patients did not complain of cardiac symptoms and did not show any significant alterations in systolic-time-interval measurements until the borderline dosage level (550 mg/m2) was attained. To evaluate myocardial function with greater accuracy, these 15 patients were submitted to right-heart catheterization and radionuclide angiography at rest and during exercise. As a result, doxorubiciri treatment had to be discontinued in three of these patients because of heart failure of stage III or IV and treatment with methyl digoxin and nifedipine was started. In these three patients cardiotonic medication could produce more or less complete cardiac recompensation. We conclude from our findings that signs of stage-III heart failure in radionuclide angiography performed while the patient is at rest and exercising should be regarded as the upper limit of the therapeutic risk, where further doxorubicin treatment is contraindicated. Cardiotonic medication during cytostatic courses should be avoided, however, because the true functional condition of the myocardium could be masked during a potentially cardiotoxic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395392
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