ISSN:
1572-8854
Keywords:
Prodine
;
opioids
;
piperidine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The meta hydroxyphenyl analog of α-prodine (1,3-dimethyl-(4-meta-hydroxy phenyl)-4-propionyloxypiperidine) free base crystallizes in the orthorhombic space group P212121. The relative configuration of the compound shows the piperidine ring is in a chair conformation, the phenyl ring, the 3-methyl, and the N-methyl are equatorial, and the 4-propionyloxy group is axial. The molecular structure is similar to that of racemic α-prodine and the potent opioid agonist, ketobemidone. There is a hydrogen bond between N(1) ... O(1) 2.79 Å.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01668620
Permalink