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  • 1
    Electronic Resource
    Electronic Resource
    Book Reviews (1980)
    Springer
    Diabetologia 19 (1980), S. 566-566 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253187
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  • 2
    Electronic Resource
    Electronic Resource
    Glycosylated haemoglobin in cord blood following normal and diabetic pregnancies (1983)
    Springer
    Diabetologia 25 (1983), S. 482-485 
    Details
    ISSN: 1432-0428
    Keywords: Glycosylated haemoglobin ; cord blood ; diabetic pregnancy ; normal pregnancy ; diabetes ; pregnancy ; diabetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cord and maternal blood samples were obtained at delivery in 25 normal and 14 diabetic pregnancies (13 insulindependent, one gestational). Total glycosylated haemoglobin, measured by the colorimetric thiobarbiturate method (mmol hydroxymethylfurfural/mol haemoglobin), was lower in cord than maternal blood (mean 18.7±1.7 versus 26.5±2.1, mean ± SD, p〈0.001). Glycosylated haemoglobin was higher following diabetic pregnancies, both in cord (diabetic 19.9± 1.6 versus normal 17.9±1.4, p〈0.001) and maternal samples (diabetic 27.7±1.5 versus normal 25.6±2.1, p〈0.005). Cord and maternal glycosylated haemoglobin correlated in the normal (r=0.60, p〈0.01) but not in the diabetic group (r=0.02, NS). Birth weight ratio was higher in infants of diabetic than of normal mothers (1.10±0.16 versus 0.99±0.13, p〈 0.05) but failed to correlate with cord or maternal glycosylated haemoglobin or, in the diabetic group, with mean blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284455
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  • 3
    Electronic Resource
    Electronic Resource
    The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 273-277 
    Details
    ISSN: 1432-1041
    Keywords: meptazinol ; pregnant and non-pregnant women ; pharmacokinetics ; single and repeated i.v. dosing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the disposition of the centrally-acting analgesic meptazinol in a group of age-matched non-pregnant and pregnant (36–38 weeks gestation) women. Ten non-pregnant and nine multiparous pregnant volunteers each received a single i.v. dose of meptazinol hydrochloride (equivalent to 25 mg base). A further group of 9 non-pregnant (including four of the original participants) and 10 multiparous pregnant subjects were given repeated i.v. doses of meptazinol hydrochloride (each equivalent to 10 mg base) at 30-min intervals for 2.5 h. Meptazinol plasma concentrations were determined by HPLC using fluorescence detection and the pharmacokinetic variables investigated. After single dosing there were no statistical differences in half-life, clearance, or apparent volume of distribution between the two groups, suggesting that the disposition of meptazinol was not altered by pregnancy. This was confirmed in the repeated dose study, in which no significant differences occurred in either the plasma concentrations achieved or in areas under the curves between the non-pregnant and pregnant subjects. Furthermore, the steady-state concentrations were comparable with those predicted from the single dose results. This indicates that there should be no requirement for dosage alteration of meptazinol during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558159
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  • 4
    Electronic Resource
    Electronic Resource
    Omeprazole in elderly duodenal ulcer patients: relationship between reduction in gastric acid secretion and fasting plasma gastrin (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 557-560 
    Details
    ISSN: 1432-1041
    Keywords: Omeprazole ; duodenal ulcer patients ; acid secretion ; plasma gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of omeprazole on acid secretion and gastrin levels has been investigated in 10 elderly duodenal ulcer patients in remission. Doses of 5, 10, 20 and 40 mg omeprazole were given once daily for 7 consecutive days and the basal (BAO) and peak (PAO) acid output and fasting plasma gastrin concentration were measured 24 h after the seventh dose. Omeprazole suppressed PAO significantly and dose-dependently after doses of 10, 20 and 40 mg, the suppression being 42%, 75% and 85%, respectively. No patient showed complete inhibition of PAO and at least 20 mg had to be given to obtain a marked inhibitory effect in all patients. Increasing the dose to 40 mg had only a slight additional effect compared to 20 mg. There was a relationship between degree of acid inhibition and the increase in fasting plasma gastrin. PAO had to be suppressed by more than 80% before a moderate increase in fasting plasma gastrin was observed. The optimal once-daily oral dose of omeprazole for inhibition of acid secretion in elderly patients appears to be 20 mg. Omeprazole 20–40 mg may cause a moderate increase in fasting plasma gastrin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279969
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  • 5
    Electronic Resource
    Electronic Resource
    Biliary secretion of felodipine metabolites in man after intravenous [14C]felodipine (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 421-424 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; bile ; dihydropyridines ; biliary secretion ; healthy volunteers ; drug metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biliary secretion of [14C]felodipine in 4 healthy human subjects was studied by use of the multiple marker dilution principle with double lumen tubes placed in the stomach and intestine. Insignificant amounts of14C activity were recovered from gastric aspirates. The individual recovery from intestinal aspirates varied from 2.9 to 8.5% of the dose of radioactivity over the period of 4.5 h after dosing. Less than 0.1% was identified as unchanged felodipine. The results show that biliary secretion is a minor route of elimination of felodipine or its metabolites. Bile collection for 4.5 h had no significant effect on the pharmacokinetics of felodipine, although the 72 h urinary recovery of radioactivity tended to be lower when bile was collected (59%) than in the control experiment (66%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336677
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  • 6
    Electronic Resource
    Electronic Resource
    Spontaneous carotid-cavernous fistula with fibromuscular dysplasia (1978)
    Springer
    Acta neurochirurgica 40 (1978), S. 123-129 
    Details
    ISSN: 0942-0940
    Keywords: Carotid arteries ; carotid-cavernous fistula ; carotid artery ; internal ; fibromuscular dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A young woman presented with a spontaneous carotid-cavernous fistula. She also had fibromuscular dysplasia of the extracranial cerebral arteries. The possible relationship of the two diseases brought up important questions concerning how to manage the patient. Treatment by obliteration of the carotid circulation on one side would be expected to increase blood flow on the other side. If the cavernous carotid artery on the second side was weakened by fibromuscular dysplasia, the increased flow might predispose to the formation of a second carotidcavernous fistula. We first attempted to avoid surgery. When progressive symptoms occurred, the cavernous sinus was obliterated with bronze wire, thus preventing venous shunting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01773120
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  • 7
    Electronic Resource
    Electronic Resource
    Non-penetrating trauma to the carotid artery with secondary thrombosis and embolism: Treatment by Thrombolysin (1977)
    Springer
    Acta neurochirurgica 37 (1977), S. 219-244 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of partially occluding post-traumatic thrombosis of the internal carotid artery and secondary embolism of the middle cerebral artery is reported. The patient was treated with Thrombolysin with coincident resolution of clinical symptoms and signs and clearing of the lesions on arteriography. This may have been fortuitous. The subject of traumatic carotid artery thrombosis is reviewed in detail, and its pathophysiology is discussed, especially in relation to facts known about occlusive vascular disease secondary to atherosclerosis and related embolie phenomena. Suggestions are made concerning the treatment of this condition, especially with regard to developing rational criteria for opening vascular beds through evaluation of collateral cerebral blood flow. The uses of microvascular surgical techniques and thrombolytic therapy are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402128
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  • 8
    Electronic Resource
    Electronic Resource
    Faecal carriage of listeria during pregnancy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb14324.x
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  • 9
    Electronic Resource
    Electronic Resource
    Authors' reply (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15324.x
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  • 10
    Electronic Resource
    Electronic Resource
    Atomic absorption spectrometric determination of manganese, silver and zinc in dental material by atomization directly from the solid state
    Amsterdam : Elsevier
    Analytica Chimica Acta 80 (1975), S. 297-301 
    Details
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(01)85083-2
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