ISSN:
1432-0827
Keywords:
Galactose
;
Glucose-6-phosphate dehydrogenase
;
Collagen
;
Galactose-1-phosphate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Abstract The bone tissue levels of galactose-1-P have been found to be a function of the concentration of galactose in blood.In vitro, the glucose-6-phosphate dehydrogenase (bone isoenzyme) was competitively inhibited by galactose-1-P. Galactose or galactitol were found ineffective. Therefore, the previously reported depressed activity of bone glucose-6-phosphate dehydrogenase in galactose-fed rats should be interpreted as mediated by galactose-1-P. When compared with their controls, galactose-fed rats showed a significantly lower growth rate which was reflected in a lower bone collagen content and in a lower percentage of salt soluble collagen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02008221
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