ISSN:
1573-8221
Keywords:
pentacyclic triterpenes
;
rat kidney
;
ion excretion
;
creatinine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The renal excretion of water, Na+, K+, and creatinine was investigated in rats 3 h after administration of a 5% load of 0.9% NaCl solution by the intragastric route. The excretion of Na+ was reduced considerably below the control level in animals receiving trihydroxylupane or heterobetulin 18–20 h before the experiment; the excretion of water, K+, and creatinine was unchanged. After administration of dihydroxylupenal in a dose of 2 mg/100 mg body weight the excretion of Na+ and water was increased. Heterobetulin also increased the excretion of K+ with the urine after administration of a 5% load of 1.25% KCl solution to rats. The results are interesting from the standpoint of the study of the relationship between the structure of substances and their physiological activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00804216
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