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  • 1
    Electronic Resource
    Electronic Resource
    Production of insulin-like growth factor I (IGF-I) and IGF-binding proteins by rat intestinal stromal cells in vitro (1998)
    Springer
    Cellular and molecular life sciences 54 (1998), S. 158-166 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Insulin-like growth factors; IGFs; IGFBP; stroma; epithelium; stromal-epithelial interactions.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. To determine if intestinal stromal cells secrete diffusible factors such as insulin-like growth factors (IGFs) capable of regulating epithelial cell growth in vitro, stromal cells were isolated by enzymatic digestion of rat intestine. Incorporation of [3H]thymidine into DNA and [14C]leucine into protein of IEC-6 cells, a model intestinal epithelial cell line, was significantly increased (two- to threefold) when the IEC-6 cells were co-cultured with stromal cells, relative to IEC-6 cells grown alone. Medium conditioned by stromal cells stimulated DNA synthesis of IEC-6 cells in a dose-dependent manner. Analysis of the conditioned medium revealed that intestinal stromal cells secreted IGF-I, but little IGF-II, in addition to an M r 32,000 IGF-binding protein (IGFBP-2) and an IGFBP having M r∼ 24,000. We conclude that rat intestinal stromal cells secrete one or more diffusible factors, which may include IGF-I and IGFBPs, capable of stimulating proliferation of IEC-6 cells in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050137
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  • 2
    Electronic Resource
    Electronic Resource
    ERYTHROCYTE 2,3-DIPHOSPHOGLYCERATE AND ASSOCIATED HAEMATOLOGICAL PARAMETERS DURING THE MENSTRUAL CYCLE AND PREGNANCY (1977)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and associated haematological parameters were measured throughout the normal menstrual cycle, in each trimester of pregnancy and on the third day post partum. There was no significant change during the menstrual cycle but the 2,3-DPG concentration was increased early in pregnancy, and thereafter gradually decreased. Although other metabolic changes are likely to contribute to the increase in 2,3-DPG concentration, it is concluded that ‘functional anaemia’, secondary to increased oxygen demand, is a more important stimulus than the decrease in haemoglobin concentration. The implications of a decreased oxygen affinity of haemoglobin, secondary to the rise in 2,3-DPG concentration, are discussed in relation to anaemia and blood transfusion in pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12617.x
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  • 3
    Electronic Resource
    Electronic Resource
    Isotope effects in abstraction and exchange reactions H + H′Br (1981)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 13 (1981), S. 845-854 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A preliminary report is given of relative reactive cross sections for four abstraction reactions H + H′Br ← HH′ + Br with attacking atom (A) H or D, and atom under attack (B) H or D. The pattern of reactive cross sections, as obtained in a crossed molecular beam experiment at a collision energy ET = 7 kcal/mol, indicates Sr(D,H) ≤ Sr(D,D) 〉 Sr(H,H) 〉 Sr(H,D). The atoms in parentheses are A and B. We describe a three-dimensional classical trajectory (CT) study on a potential-energy surface proposed in 1969 by Parr and Kuppermann (PK); the CT results are in fair accord with experiment. It is suggested that (D,H) has the largest cross section because it exhibits the most favorable relative timing of A approach to BC rotation. On the basis of CT it appears that the same sequence of cross sections and the same rationale may be applied to the exchange reactions H + BrH′ ← HBr + H′.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550130908
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