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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 16 (1937), S. 1282-1284 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung In Versuchen am Herz-Lungenpräparat wird gezeigt, daß nach einer einmaligen Injektion einer größeren Menge von Adrenalin gleichzeitig mit der Erweiterung der Kranzgefäße eine Insuffizienz des Herzmuskels auftritt, die zu einer mächtigen, langanhaltenden Milchsäureabgabe des Herzens an das Blut führt. Nach einer einmaligen Injektion von Sympatol kommt es ebenfalls zu einer Erweiterung der Kranzgefäße, die sogar die nach Adrenalin an Stärke und an Dauer übertrifft. Die Wirkung auf den Kohlehydratstoffwechsel ist aber eine wesentlich mildere. Es kommt wohl auch anfänglich zu einer Milchsäureabgabe des Herzens, diese ist aber sehr viel geringer als die nach Adrenalin und vor allem von viel kürzerer Dauer, so daß schon nach kurzer Zeit trotz der Erweiterung der Kranzgefäße wieder eine Aufnahme von Milchsäure durch das Herz erfolgt.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0630
    Keywords: 42.70 ; 61.46. + w ; 68.55.Ln
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Light waveguides containing silver, introduced by ion-exchange process in soda-lime glass, has been annealed in hydrogen atmosphere at temperatures in the 120–250°C range. Annealings cause a near-surface precipitation of metallic silver to form nanometer-size clusters with good uniformity in size and spatial distribution. Hydrogen permeation and ion-exchange between hydrogen and sodium (which remains in the glass matrix after silver-for-sodium exchange) are steps of the annealing process. A further step is the diffusion of silver ions towards the surface, and its eventual precipitation, with an activation energy close to that measured for silver-sodium interdiffusion in glasses of comparable composition.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0630
    Keywords: PACS: 42.70; 61.46.+w; 68.55.Ln
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract.  Light waveguides containing silver, introduced by ion-exchange process in soda-lime glass, has been annealed in hydrogen atmosphere at temperatures in the 120–250 °C range. Annealings cause a near-surface precipitation of metallic silver to form nanometer-size clusters with good uniformity in size and spatial distribution. Hydrogen permeation and ion-exchange between hydrogen and sodium (which remains in the glass matrix after silver-for-sodium exchange) are steps of the annealing process. A further step is the diffusion of silver ions towards the surface, and its eventual precipitation, with an activation energy close to that measured for silver-sodium interdiffusion in glasses of comparable composition.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 45 (1993), S. 337-341 
    ISSN: 1432-1041
    Keywords: Minoxidil ; sulphotransferase ; liver ; extrahepatic tissues ; platelets ; interindividual variability ; adults ; neonates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Minoxidil requires to be sulphated to exert its hypotensive effect. We report on interindividual variability in the rate of minoxidil sulphation in 118 specimens of human liver and in platelets obtained from 100 healthy subjects and 100 newborns. The frequency distribution histogram of the hepatic activity of minoxidil sulphotransferase was positively skewed; the mean was 631 pmol · min−1 · mg−1. After logarithmic transformation of the enzyme activity, the frequency distribution histogram became symmetrical and did not significantly deviate from normality. The rate of minoxidil sulphation was not different in platelets from adults (0.74 pmol · min−1 · mg−1) and newborns (1.16 pmol · min−1 · mg−1). The frequency distribution histograms were positively skewed and the results of normal equivalent deviation analysis was compatible with the presence of at least two subgroups of sulphotransferase in liver and platelets. Thus, two phenotypes of sulphotransferase exist in human liver and platelets, and the “extensive sulphator” phenotype contributes to skewing the frequency distribution. In platelets, the percentage of subjects that fall in the two subgroups is different at birth and in adulthood. This can explain the different shape of the frequency distribution in newborn and adult platelets and suggests that platelet minoxidil sulphotransferase undergoes modification after birth.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: Chloroquine ; Stereoselectivity ; Histamine ; methyltransferase ; liver ; brain ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract This study was designed to determine whether both enantiomers of chloroquine inhibit histamine N-methyltransferase. The mean estimates of IC50 for the d- and l-enantiomers of chloroquine were 4.9 and 17.8 μM (liver), respectively and 6.9 and 21.6 μM (brain), respectively. Ki estimates were significantly lower with d- than with l-chloroquine; hence, d-chloroquine interacts with the enzyme more effectively than l-chloroquine. If the adverse effects of chloroquine are due to the inhibition of histamine N-methyltransferase, therapy with the l-enantiomer might have lower toxicity. The residual activity of histamine N-methyltransferase should reflect both the degree of inhibition by chloroquine and the level of enzyme expression. The rate of histamine methylation was measured in 100 human liver samples and its range and fold of variation were 29% and threefold, respectively. Susceptibility to chloroquine should be greater in subjects with limited expression of histamine N-methyltransferase.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The preservation and restoration of severely weakened pulpless teeth is a difficult and relatively unpredictable procedure. This study evaluated the resistance to fracture of experimentally weakened bovine roots internally reconstructed with different filling materials in combination with prefabricated post compared with restored roots that were relatively intact. The roots of 75 mandibular bovine incisors with similar bulks were selected. Of these, 60 were internally prepared to standardized dimensions, thereby simulating weakness. All roots were filled with different restorative materials. The specimens were submitted to the fracture resistance testing with the application of a tangential compressive loading at an angle of 135° in relation to the long axes of the roots. Results indicated statistically significant differences in relation to the root conditions. Weakened roots were less resistant to fracture than were controls. The roots restored with the resin cement demonstrated the lowest fracture resistance values, but statistically significant differences were observed only when compared with those restored by the resin-modified glass–ionomer cement. Resin-modified glass–ionomer cement, polyacid-modified resin composite and resin composite behaved similarly without statistically significant differences among them. None of the materials evaluated were capable of achieving the fracture resistance recorded for unweakened controls.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 7-8 (1985), S. 517-520 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 19-20 (1987), S. 948-953 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 65 (1992), S. 387-391 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 1 (1984), S. 511-515 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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