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  • 1
    Electronic Resource
    Electronic Resource
    Intrahepatic metastatic nodules of hepatocellular carcinoma detected at Lipiodol-CT: imaging-pathologic correlation (1997)
    Springer
    Abdominal imaging 22 (1997), S. 253 -258 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Contrast media, fatty acid—Lipiodol, hepatic intraarterial—Liver neoplasms, angiography—Liver neoplasms, CT—Liver neoplasms, diagnosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The purpose of this study was to determine whether tiny (〈2 cm) areas of iodized-oil retention diagnosed as intrahepatic metastatic nodules of hepatocellular carcinoma (HCC) at computed tomography (CT) following intraarterial injection of Lipiodol (Lipiodol-CT) correlate with truly cancerous foci on the corresponding sectioned pathologic specimens. Methods: Thirty-two consecutive patients with biopsy-proven HCC (26 men and six women, aged 41–72 years) underwent prospective evaluation with Lipiodol-CT before undergoing surgery (hepatic resection, 30 patients; liver transplantation, two patients). Imaging findings were correlated with intraoperative and pathologic findings. Results: Twenty-one areas of retained Lipiodol (0.5–1.6 cm in diameter, mean ± SD: 0.9 ± 0.3 cm) had features consistent with intrahepatic metastatic nodules of HCC on Lipiodol-CT scans. Nineteen of the 21 areas correlated with tumor deposits at pathologic examination of the surgical specimens, whereas two of 21 were due to abnormal retention of iodized oil within noncancerous liver parenchyma. The positive predictive value of findings at Lipiodol-CT for the diagnosis of intrahepatic metastatic nodule of HCC was 90.5%. Conclusions: Findings at Lipiodol-CT enable a reliable diagnosis of intrahepatic metastatic nodules of HCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900183
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: a European experience (1997)
    Springer
    European radiology 7 (1997), S. 514-519 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Alcohol ; Liver neoplasms ; Therapy ; Interventional procedure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of our work was to evaluate the long-term results of percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) in patients with liver cirrhosis. A total of 184 cirrhotic patients with HCC underwent PEI as the only anticancer treatment over an 8-year period. Patients were followed after therapy by means of clinical examinations, laboratory tests, and US and CT studies performed at regular time intervals. Survival rates were determined according to the Kaplan-Meier method. The overall survival was 67 % at 3 years, 41 % at 5 years, and 19 % at 7 years. The 3-, 5-, and 7-year survival rates of patients with single HCC ≤ 3 cm (78, 54, and 28 %, respectively) were significantly higher (p 〈 0.01) than those of patients with single HCC of 3.1–5 cm (61, 32, and 16, respectively) or multiple HCCs (51, 21, and 0 %, respectively). Survival of Child-Pugh A patients (79 % at 3 years, 53 % at 5 years, and 32 % at 7 years) was significantly longer (p 〈 0.01) than that of Child-Pugh B patients (50 % at 3 years, 28 % at 5 years, and 8 % at 7 years). A selected group of 70 patients with Child-Pugh A cirrhosis and single HCC ≤ 3 cm had a 7-year survival of 42 %. Long-term survival of cirrhotic patients with HCC treated with PEI is comparable to that reported in published series of matched patients submitted to surgical resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050194
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of propafenone during acute and chronic administration (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 187-194 
    Details
    ISSN: 1432-1041
    Keywords: propafenone ; 5-OH-propafenone ; antiarrhythmic effect ; pharmacokinetics ; chronic treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224–928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 mg p.o., and after 1 and 3 months (only 5 out of 10 patients) of therapy with 300 mg t.d.s. After 1 month of treatment the plasma elimination half-life of propafenone (6.7 h) was almost twice as long as after a single dose (3.5 h), and the area under the plasma propafenone concentration-time curve (7620 ng·ml−1·h) was significantly larger than after single dose (3522 ng·ml−1·h); this was also true for the metabolite. The ratio of the AUCs of 5-OH-propafenone and propafenone decreased from the single dose (0.63) to 1 month (0.32). These variables remained stable up to 3 months. Eight patients had ≧75% reduction of premature ventricular complexes after 3 days of therapy, and in 7 they were completely suppressed; the response was maintained over 1 to 3 months. Side effects were minor and in no case had the drug to be withdrawn or the dose reduced. Thus, the kinetics of propafenone were time-dependent. Its active metabolite did not accumulate greatly during chronic treatment. The lasting antiarrhythmic effect observed in some patients suggests a b.d.s. regimen instead of t.d.s. dosing in selected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614557
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  • 4
    Electronic Resource
    Electronic Resource
    Methacrylates allergy in a professional beautician (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 53 (2005), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2005.0407n.x
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  • 5
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic separation and mass spectrometric identification of propafenone, 5-hydroxypropafenone and N-depropylpropafenone
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 424 (1988), S. 211-214 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)81097-X
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  • 6
    Electronic Resource
    Electronic Resource
    Post-treatment diagnostic accuracy of a new enzyme immunoassay to detect Helicobacter pylori in stools (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Helicobacter pylori has attracted increasing attention among gastroenterologists because of its pathogenic potential, stimulating the search for non-invasive diagnostic tests.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:In this study the efficacy of a new enzyme immunoassay designed to detect H. pylori antigens in stools (HpSA) was evaluated before and after eradication therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:HpSA was performed on stool samples collected from 268 patients whose H. pylori status was defined on the basis of concordant results for the 13C-urea breath test, rapid urease test and histology. The H. pylori-positive patients were treated with a 1-week triple therapy to eradicate the infection. One (T30) and 3 months (T90) after the end of therapy, 13C-urea breath test and HpSA were repeated in the treated patients.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The overall diagnostic accuracy of HpSA at T30 (83%, 95% confidence interval (CI) 77–89%) was significantly lower in comparison to the values obtained at baseline (94%, 95% CI: 91–97%) and at T90 (97%, 95% CI: 94–99%). No significant difference was found between the diagnostic accuracy of HpSA at baseline and at T90 (P=0.253).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:The present data suggest that HpSA provides a low diagnostic accuracy when used shortly after treatment. It needs a longer period of follow-up (8–12 weeks) to reach a reliability comparable to the 13C-urea breath test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.00928.x
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  • 7
    Electronic Resource
    Electronic Resource
    A package for representing C 1 interpolating surfaces: Application to the lagoon of Venice's bed (1999)
    Springer
    Numerical algorithms 20 (1999), S. 197-215 
    Details
    ISSN: 1572-9265
    Keywords: interpolation of scattered data ; algorithms for functional minimization ; computer graphics and computational geometry ; 65D05 ; 65Y25 ; 65D15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract The paper deals with the description of a method and the accompanying software, the package LABSUP, for representing C 1 interpolating surfaces. The application to the lagoon of Venice's bed is also proposed. The surfaces are built over the Delaunay triangulation and the polynomial patches used for the representation can be chosen among the Q 18 element, the Clough-Tocher or the Powell–Sabin finite elements or simply using global Bézier methods. The first three patches require the knowledge of the gradients at the nodes, or at least a suitable estimation of them. Therefore, interesting in itself is the derivative estimation process based on the minimization of the energy functional associated with the interpolant. For the representation of the lagoon of Venice's bed we only used the reduced Clough-Tocher finite element, due to the high number of points involved for which one needs to compute the Delaunay triangulation, and simply the partial derivatives of first order. A brief description of the software modules together with some graphical results of parts of the lagoon of Venice's bed are also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019103901231
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  • 8
    Electronic Resource
    Electronic Resource
    Maximum exercise in oxygen (1961)
    Springer
    European journal of applied physiology 18 (1961), S. 465-467 
    Details
    ISSN: 1439-6327
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The maximum oxygen consumption, as measured during strenuous exercise is increased ab. 10% when breathing pure oxygen, of the same order of magnitude as the O2 increase in blood. The better performance in O2 is therefore explained as due to the increased blood O2 available, other factors, such as a higher saturation of Hb or a faster blood circulation, having no appreciable importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00699459
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