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  • 1
    ISSN: 1432-1076
    Keywords: Midline defects ; Anophthalmos ; Microphthalmos ; Cryptophtalmos ; Hypothalamic defects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four children with severe congenital eye anomalies are described of which three had related symptoms. Two had bilateral anophthalmia, the optic nerves not detectable by computed cranial tomography and magnetic resonance imaging, and the third child had bilateral microphthalmia and coloboma iridis. The fourth patient had bilateral cryptophthalmia as part of Fraser syndrome. All four patients were of small stature. In three of them growth hormone deficiency was demonstrated which was of hypothalamic origin as shown by growth hormone releasing hormone tests. In the fourth child hypogonadotropic hypogonadism and tertiary thyroid deficiency were diagnosed which responded well to thyroxine treatment. Pathogenetically the described disorders are due to congenital defects of midline structures as a common “developmental field”.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 145 (1986), S. 384-388 
    ISSN: 1432-1076
    Keywords: Hypopituitarism ; Pubertal development ; Human chorionic gonadotropin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The spontaneous or therapeutically induced pubertal development of 65 male patients with idiopathic hypopituitarism was analysed. Spontaneous puberty occurred in 82% of the patients with prepubertal isolated growth hormone deficiency and in 32.5% of those with impairment in the secretion of more than one pituitary hormone. Out of this group, 36 patients could be studied longitudinally. In 15 patients, the onset of spontaneous puberty was delayed, on average, 3.2 years. It started at a bone age of 10.36±1.25 “years” and followed a pattern similar to that of normal boys. Testosterone levels at each pubertal stage were not different from those of normal boys. Mean peak height velocity reached 7.27±1.82 cm/year. In 21 patients with gonadotropin deficiency, hCG treatment was started at a chronological age of 19.04±2.17 years and a bone age of 12.94±0.80 “years”. Plasma testosterone attained normal adult levels in the majority of boys, while the development of sexual characteristics showed a wide variation. Mean growth velocity during the first year of hCG therapy reached 6.11±2.47 cm/year. Partial gonadotropin deficiency was diagnosed in two boys. Although testosterone seems today to be, for practical reasons, the replacement therapy of choice, hCG treatment is an alternative for hypopituitary patients with absent gonadotropin function.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 58 (1990), S. 1231-1238 
    ISSN: 1572-9613
    Keywords: Bethe-Peierls map ; Möbius transformation ; logistic map ; mean-field percolation ; McKay-Berker-Kirkpatrick spin-glass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The phase diagram of the one-state Potts model on the closed asymmetric Cayley tree with branching ratior=2 is obtained from the Bethe-Peierls map. The route to chaos, via the period doubling cascade, is obtained by considering the antiferromagnetic coupling limit. The connection of the Potts model with the percolation problem is shown by calculating the order parameter, its susceptibility, the internal energy, and the specific heat as well as their asymptotic behavior at the paramagnetic-ferromagnetic critical point. Due to the type of the lattice and to the polynomial character of the map, this is the simplest known example of a McKay-Berker-Kirkpatrick spin-glass.
    Type of Medium: Electronic Resource
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