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  • 1
    Electronic Resource
    Electronic Resource
    An autopsy case of human T lymphotropic virus type I-associated myelopathy (HAM) with a duration of 28 years (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 219-222 
    Details
    ISSN: 1432-0533
    Keywords: HTLV-I ; Tropical spastic paraparesis ; Chronic progressive myelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of human T lymphotropic virus I-associated myelopathy (HAM) of a duration of 28 years in a 61-year-old man with serological confirmation of HTLV-I infection was reported. The spinal cord was grossly atrophic. There was severe symmetrical degeneration of the lateral funiculi, particularly of the bilateral pyramidal tracts, involving all levels of the spinal cord, but anterior horn cells were relatively well preserved. In the most severely damaged middle and lower thoracic segments, the white matter degeneration also involved the anterior funiculi. In the degenerated white matter, both the myelin and axons were equally lost and had been replaced by glial scars. Marked adventitial fibrosis was commonly seen in small parenchymal vessls in both the white and gray matter. Although there was no evidence of inflammation in the spinal cord, mild lymphocytic infiltration was occasionally observed in the subarachnoid and perivascular spaces in the brain stem, cerebellum and cerebrum. This case was considered as a burnt-out case of HAM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334512
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  • 2
    Electronic Resource
    Electronic Resource
    Sporadic motor neuron disease with Lewy body-like hyaline inclusions (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 555-560 
    Details
    ISSN: 1432-0533
    Keywords: Sporadic motor neuron disease ; Lewy body-like hyaline inclusions ; Immunocytochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lewy body-like hyaline inclusions were immunocytochemically and electron microscopically investigated in a patient with sporadic motor neuron disease. The hyaline inclusions were chiefly observed within the perikarya of both normal-looking and chromatolytic anterior horn cells in the lumbar spinal cord, but some were detected in the axons and dendrites. Usually, a single inclusion was found in the perikaryon, but in rare cases two or more were observed. Immunocytochemically, these inclusions were intensely immunostained with anti-ubiquitin anti-body. Ultrastructurally, the hyaline inclusions were chiefly composed of randomly arranged linear structures associated with ribosome-like granules, varying from compactly arranged linear densities to more loosely packed ones. They contained scattered vesicles of various sizes and occasionally a focal accumulation of randomly arranged 10-nm neurofilaments or 13–25-nm filamentous structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687719
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  • 3
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural studies of hyaline inclusions in sporadic motor neuron disease (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 295-301 
    Details
    ISSN: 1432-0533
    Keywords: Hyaline inclusions ; Motor neuron disease ; Amyotrophic lateral sclerosis ; Immunocytochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated hyaline inclusion bodies (HI) immunocytochemically and ultrastructurally in six cases of sporadic motor neuron disease (MND). All HI contained large amounts of ubiquitin and some HI were stained at the core or the center with anti-neurofilament antibody, with the surrounding halo unstained. No HI were stained with antibodies raised against cytoskeletal proteins such as high-molecular weight microtubule-associated proteins and phosphorylated tau. Ultrastructurally, HI were chiefly composed of filaments measuring about 20 nm in diameter thicker than neurofilaments, and contained fine granules and frequently one or more of four characteristic profiles, i.e., small electron-dense materials resembling Bunina bodies, bundles of tubular filaments measuring approximately 20 nm in diameter, large electron-dense cores, and focal accumulations of randomly arranged neurofilaments. Hyaline inclusions can be regarded as one of the characteristic markers for sporadic MND as well as familial amyotrophic lateral sclerosis. Hyaline inclusions have a markedly heterogeneous ultrastructure and, therefore, differences in immunoreactivity with antineurofilament antibodies are not unexpected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308815
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  • 4
    Electronic Resource
    Electronic Resource
    Sporadic amyotrophic lateral sclerosis with extensive neurological involvement (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 211-215 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Respirator support ; Long survival ; Extensive involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report an autopsy case of respirator-assisted long-survival sporadic amyotrophic lateral sclerosis (ALS) with extensive involvement extending beyond the motor system. The involved areas included the globus pallidus, subthalamic nucleus, red nucleus, substantia nigra, Clarke's column, intermediolateral nucleos, Onuf's (Onufrowicz) nucleus, middle root zone of the posterior column, and the spinocerebellar tract. There was no impairment of ocular movements. Such sporadic ALS cases with extensive involvement extending beyond the motor system may constitute a distinct subgroup of this disease that differs from long-survival ALS (with or without respirator support) in which only the motor system is affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311398
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  • 5
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural studies of the motor cortex in amyotrophic lateral sclerosis (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 578-585 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Motor cortex ; Betz cells ; Immunocytochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report concerns an immunocytochemical and ultrastructural study of the motor cortices of 11 patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 normal individuals served as controls. Antibodies against phosphorylated neurofilament (PNF; 200 kDa), ubiquitin, glial fibrillary acidic protein (GFAP) and phosphorylated tau protein were used. The pyramidal cells of layer III of all ALS patients were stained, with varying intensities, by the antibody to PNF. By contrast, Betz cells reacted less frequently with this antibody. Staining for GFAP was noted in numerous astrocytes in layer III and at the transition between white matter and motor cortex of most patients. Ubiquitin-positive inclusions were only occasionally seen in Betz cell and pyramidal cell of layer V. These observations indicate that alterations of the motor cortex occur first in the pyramidal cells of layer III rather than in Betz cells. Pyramidal cells and Betz cells were not stained by the antibody to phosphorylated tau protein. In controls, pyramidal cells and Betz cells were less frequently stained with the anti-neurofilament antibody than those from ALS patients. Immunoreactivity of GFAP in layer III and at the junction of white matter and motor cortex was observed in only one patient. Ultrastructural examination revealed that the Betz cells of some ALS patients had Bunina bodies (BB), Lewy body-like inclusions (LBI) and skein-like inclusions (SI), as well as bundles of filaments that were thicker than neurofilaments; some of these filaments appeared to be constricted. The incidence of these inclusions was lower than that seen in anterior horn neurons. Cytoplasmic inclusions such as BB, LBI, and SI were not observed in any of the controls. Our findings suggest that the cytopathology of upper motor neurons is similar to that of lower motor neurons and that the changes seen in Betz cells appear to be a reflection of the lower motor neuron alterations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293318
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  • 6
    Electronic Resource
    Electronic Resource
    Superconductivity in Entirely End-Bonded Multi-Walled Carbon Nanotubes (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 13-16 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: We report that entirely end-bonded multi-walled carbon nanotubes (MWNTs) withinTomonaga-Luttinger liquid (TLL) states at high temperatures can show superconductivity withthe transition temperature Tc as high as 12K that is approximately 40-times larger than those inropes of single-walled nanotubes. We find that emergence of this superconductivity is verysensitive to junction structures of Au electrode/MWNTs. This indicates that MWNTs withoptimal numbers of electrically activated shells can allow the superconductivity that overcomesthe TLL sates, due to intershell effects
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.13.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Laser annealing of silicon clusters (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 5349-5351 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Positive silicon cluster ions prepared by laser vaporization in a supersonic beam and trapped in an ion cyclotron resonance cell were probed in chemisorption reactions with ethylene and ammonia. Clusters in the 36–51 atom size range were effectively annealed to unique structural forms by excitation with a XeCl excimer laser followed by cooling through infrared radiation and collisions with argon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.459656
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation of Prolylendopeptidase-Inhibiting Peptides from Bovine Brain
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 202 (1994), S. 809-815 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1994.2002
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  • 9
    Electronic Resource
    Electronic Resource
    Thermodynamic characterization of partially denatured states in the denaturation process of bovine α-lactalbumin by inorganic denaturants
    Amsterdam : Elsevier
    BBA - Protein Structure 494 (1977), S. 343-353 
    Details
    ISSN: 0005-2795
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2795(77)90164-7
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  • 10
    Electronic Resource
    Electronic Resource
    Equilibrium and kinetics of thermal unfolding of yeast 5.8S ribosomal RNA in aqueous salt solutions
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 5 (1983), S. 26-32 
    Details
    ISSN: 0141-8130
    Keywords: 5.8S RNA ; Yeast ; differential melting ; helix-coil transition ; structure model ; temperature jump ; thermal unfolding
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0141-8130(83)90074-0
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