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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 333-336 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE the thyroid hormone is held by peptide bonds within the molecule of its storage form, thyroglobulin, it is generally accepted that hydrolytic enzymes are concerned with its controlled release into the blood stream. The proteolytic activity of thyroid tissue has been shown to vary with the ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Circulating immune complexes in excess of the equivalent of 20 m̈g/ml heat-aggregated IgG were found in fourteen out of twenty patients diagnosed as having preeclampsia.2. Only six of the nineteen controls tested had similar levels of immune complexes. Recent studies have established that concentrations of heat aggregated IgG in excess of 20 m̈g/ml activate human platelets to release sufficient concentrations of vasoactive agents to constrict a human blood vessel in vitro.3. It is therefore suggested that in vivo platelet activation by circulating immune complexes may release sufficient concentrations of vasoactive agents to contribute to the hypertension in pre-eclampsia.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 2 (1982), S. 137-139 
    ISSN: 1437-160X
    Keywords: Rheumatoid vasculitis ; Rheumtoid arthritis ; B8 DR3 phenotype ; Tissue typing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A statistically significant association of clinical rheumatoid vasculitis (excluding nodules or nail-fold infarcts only) with the HLA B8 DR3 phenotype was found when comparing 30 patients with vasculitis with 84 classic or definite rheumatoid patients without clinical vasculitis. The previously reported association on HLA DR4 with rheumatoid disease was also confirmed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 113-117 
    ISSN: 1437-160X
    Keywords: Ross River virus ; Polyarthritis ; Immune complexes ; Complement ; Rheumatoid factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheumatoid factor were compared in the serum of 20 patients during active disease and after recovery. The results were identical and within the normal range in both phases. One patient developed IgM rheumatoid factor in a low titre late in his illness. Although these findings do not entirely exclude a role for immune complexes formed at the onset in the circulation or tissues, it is concluded from this and other evidence that circulating complexes are not commonly responsible for the persistence of syndroms in this disease.
    Type of Medium: Electronic Resource
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