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  • 1
    Electronic Resource
    Electronic Resource
    Differences in the effects of the antirheumatic drugs, bucillamine andd-penicillamine, on mitogen-induced proliferation of mouse spleen cells (1990)
    Springer
    Inflammation research 30 (1990), S. 363-368 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of bucillamine [N-(2-mercapto-2-methylpropionyl)-l-cysteine] a new antirheumatic drug, on the concanavalin A (Con A)-induced proliferation of mouse spleen cells was compared with the effect ofd-penicillamine (d-pen). Bucillamine inhibited the Con A-induced incorporation of thymidine (TdR) into mouse spleen cells in a dose-dependent fashion. At the concentration of 10−4 M, bucillamine inhibited the incorporation by approximately 80%. The inhibitory effect of bucillamine was not enhanced by the addition of copper. In contrast,d-pen showed the same degree of inhibition only in the presence of copper. (4R)-7,7-Dimethyl-6-oxo-tetrahydro-3H-1,2,5-dithiazepine-4-carboxylic acid (SA981), an intramolecular disulfide derivative of bucillamine, also showed the same degree of inhibition as bucillamine in the absence and presence of copper, whereasd-penicillamine disulfide did not show the inhibitory effect even in the presence of copper. The inhibitory effects of bucillamine and SA981 were not abolished significantly by the addition of catalase which restored the inhibition byd-pen plus copper. The mechanism of inhibition byd-pen plus copper is believed to involve the production of hydrogen peroxide resulting from the oxidation ofd-pen. The results in this study, however, indicated that the inhibitory effect of bucillamine is not due to the production of hydrogen peroxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966300
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  • 2
    Electronic Resource
    Electronic Resource
    Availability of colloidal ferric oxides to coastal marine phytoplankton (1995)
    Springer
    Marine biology 122 (1995), S. 1-11 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cell growth of a coastal marine diatom, Phaeodactylum tricornutum (stock cultures), and two red tide marine flagellates, Heterosigma akashiwo and Gymnodinium mikimotoi (stock cultures), in the presence of soluble chelated Fe(III)-EDTA (1:2) and of four different phases of ferric oxide colloids were experimentally measured in culture experiments at 20°C under 3000 lux fluorescent light. Soluble Fe(III)-EDTA induced the maximal growth rates and cell yields. The short-term uptake rate of iron by H. akashiwo in Fe(III)-EDTA medium was about eight times faster than that in solid amorphous hydrous ferric oxide (Fe2O3·xH2O) medium. In culture experiments supplied with four different ferric oxide forms, the orders of cell yields are amorphous hydrous ferric oxide〉γ-FeOOH (lepidocrocite)〉Fe5O7(OH)·4H2O (hydrated ferric oxyhydroxide polymer 〉α-FeOOH (goethite). The specific growth rates (μ) at logarithmic growth phase in Fe(III)-EDTA, amorphous hydrous ferric oxide and γ-FeOOH media were significantly greater than those in Fe5O7 (OH)·4H2O and α-FeOOH media. The thermodynamically stable forms such as Fe5O7(OH)·4H2O and α-FeOOH supported a little or no phytoplankton growth. The iron solublities and/or proton-promoted iron dissolution rates of these colloidal ferric oxides in seawater at 20°C were determined by simple filtration techniques involving γ-activity measurements of 59Fe. The orders of solubilities and estimated dissolution rate constants of these ferric oxides in seawater were consistent with that of cell yields in the culture experiments. These results suggest that the availability of colloidal iron to provide a source of iron for phytoplankton is related to the thermodynamic stability and kinetic lability of the colloidal ferric oxide phases, which probably control the uptake rate of iron by phytoplankton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349272
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  • 3
    Electronic Resource
    Electronic Resource
    Bioavailable iron species in seawater measured by macroalga (Laminaria japonica) uptake (1995)
    Springer
    Marine biology 123 (1995), S. 173-178 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The bioavailability of iron in seawater filtered through a 0.025-μm filter was investigated using 59Fe-labeled iron uptake by the macroalga Laminaria japonica (Areschoug: Phaeophyta) (collected in the northern Japan Sea 1993) as an assay. About 80% of the iron in the 0.025-μm filtered coastal seawater was soluble and/or small colloidal organically bound iron, associated with natural organic ligands forming complexes with ferric ion. After decomposition of the organic matter by ultraviolet (UV) irradiation, 55% of the iron addition [or 0.6 nM, nearly the concentration of Fe(OH) 2 + in equilibrium with amorphous hydrous ferric oxide in seawater at pH 8.0] in the 0.025-μm filtered coastal seawater was taken up by the macroalga. Since the iron concentrations in the 0.025-μm filtered coastal seawater are 0.1 to 2.0 nM and only 0.6 nM of the iron is likely available to biota over 1 to 2 d, we suggest that only small amounts of bioavailable iron exist in coastal seawater not affected by inflow from land and that a significant fraction of dissolved (〈0.025 μ) iron occurs in forms, such as organic iron complexes, other than the simple hydroxo-complex species predicted by thermodynamic models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00350337
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of natural and synthetic organic-Fe(III) complexes in an estuarine mixing model on iron uptake and growth of a coastal marine diatom, Chaetoceros sociale (1999)
    Springer
    Marine biology 134 (1999), S. 761-769 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cell growth of a coastal marine diatom, Chaetoceros sociale, in the presence of different premixed organic-Fe(III) complexes [EDTA-Fe(III) (100:1 and 2:1), citric-Fe(III) (100:1) and fulvic-Fe(III) (0.1, 0.2 and 1 ppm C)] and solid amorphous hydrous ferric oxide [am-Fe(III) or Fe(III) hydroxide] were experimentally measured in culture experiments at 10 °C under 3000 lux fluorescent light. Fulvic-Fe(III) (0.1 and 0.2 ppm C) and citric-Fe(III) (100:1) induced maximal cell yields of C. sociale. The order of cell yields was: fulvic-Fe(III) (0.1 and 0.2 ppm C) ≥ citric-Fe(III) (100:1) 〉 EDTA-Fe(III) (2:1) ≫ solid am-Fe(III) 〉 EDTA-Fe(III) (100:1) ≫ fulvic-Fe(III) (1 ppm C). The short-term iron uptake rates by C. sociale in fulvic-Fe(III) (0.1 and 0.2 ppm C) and citric-Fe(III) (100:1) media were about five to six times faster than those in EDTA-Fe(III) (100:1) and solid am-Fe(III) media. The dissociative precipitation rates of premixed organic-Fe(III) complexes in seawater at 10 °C were determined by simple filtration (0.025 μm) involving γ-activity measurements of 59Fe. The order of estimated initial Fe(III) dissociative precipitation rates of these organic-Fe(III) complexes in seawater were nearly consistent with those of cell yields in the culture experiments and short-term iron uptake rates by C. sociale [except for fulvic-Fe(III) (1 ppm C) medium]. In fulvic-Fe(III) (0.1 and 0.2 ppm C), citric-Fe(III) (100:1) and EDTA-Fe(III) (2:1) media, the concentrations of dissolved organic-Fe(III) complexes in initial culture experiments are prone to supersaturate under the culture conditions. The supersaturated dissolved organic-Fe(III) complex in seawater supplies biologically available inorganic Fe(III) species in culture media through its dissociation at high pH and high levels of seawater cations. Therefore, the natural dissolved organic-Fe(III) complexes supplied by riverine input may play an important role in supplying bioavailable iron in estuarine mixing system and coastal waters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050593
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  • 5
    Electronic Resource
    Electronic Resource
    Direct Measurement of Titanium Pipe Diffusion Coefficients in Sapphire (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 558-559 (Oct. 2007), p. 939-942 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The diffusion behavior of Ti3+ along basal dislocations in sapphire has been investigatedby SIMS technique. High-density unidirectional dislocations were introduced by thehigh-temperature mechanical deformation, and Ti3+ ions were subsequently diffused along thedislocations. The SIMS diffusion profiles clearly showed diffusion tail due to the short circuitdiffusion along the dislocations called pipe diffusion. Lattice diffusion coefficient and pipediffusion coefficient of Ti3+ at 1300°C were measured to be 1.0±0.2×10-19 [m2/sec] and 2.0±0.6×10-13 [m2/sec], respectively
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/17/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.558-559.939.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Space-resolved measurement of internal magnetic field in a bumpy torus by Li0-beam probe spectroscopy (1985)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 857-859 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new method combining Li0-beam probing and spectroscopic techniques has been developed to measure local magnetic fields in a bumpy torus. A collimated thermal Li0 beam is injected into the plasma. The Zeeman pattern of the lithium resonance radiation (22S–22P, 6708 A(ring)) is observed with a Fabry–Perot interferometer. The strength of the local magnetic field is determined from the splitting between two π components of the 22S1/2–22P1/2 transition with the spatial resolution of about 7 mm. The magnetic fields from 2 to 4 kG were measured with accuracy of ±2%. This method is applicable to plasmas of a line-integrated electron density below 5×1012 cm−2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138072
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  • 7
    Electronic Resource
    Electronic Resource
    GENETIC CONTROL OF PQ PROLONGATION OF THE ELECTROCARDIOGRAM IN THE MOUSE IMMUNIZED WITH THE KILLED GROUP A STREPTOCOCCI (1983)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 10 (1983), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Genetic control of PQ prolongation of the electrocardiogram (ECG) in the mouse, immunized with killed group A streptococci, was studied by using various congenic mice. Mice of H-2a, H-2k and H-2f haplotypes showed high frequencies of PQ prolongation, while haplotypes of H-2b, H-2d and H-2s showed low frequencies of PQ prolongation. Studies using various recombinant mice revealed that at least one immune-associated (Ir) gene mapped in the left side of the I-B subregion. High responsiveness of F1 hybrids of H-2b and H-2d, as well as B1O.A(5R) and B10.A(3R), suggests the existence of a complementing gene. In addition, the differences between C3H and CKB, as well as differences between C3H.SW and CWB, indicate that another Ir gene maps in the immunoglobulin heavy chain (Igh) coding loci. Repeated injections of anti-I-J or anti-I-A antisera also modified this PQ prolongation. These results suggested that both the major histocompatibility complex (MHC) and immunoglobulin (Igh) loci seem to be playing important roles in the pathogenesis of PQ prolongation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1983.tb01014.x
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  • 8
    Electronic Resource
    Electronic Resource
    A biological response modifier, PSK, inhibits reverse transcriptase in vitro
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 149 (1987), S. 562-567 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(87)90404-9
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibition of initiation of DNA synthesis by aminoglycoside antibiotics
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 122 (1984), S. 460-465 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(84)90498-4
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  • 10
    Electronic Resource
    Electronic Resource
    Photochromism of 1-phenoxyanthraquinones
    Amsterdam : Elsevier
    Journal of Photochemistry and Photobiology A: Chemistry 74 (1993), S. 211-219 
    Details
    ISSN: 1010-6030
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1010-6030(93)80119-T
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