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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 51 (1997), S. 481-484 
    ISSN: 1432-1041
    Keywords: Key words Lamotrigine ; Breast feeding; protein binding ; placental transfer ; neonatal drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To investigate the transfer of lamotrigine in pregnancy and during lactation from a mother on lamotrigine treatment to her child. Methods: Concentrations of lamotrigine were measured by high-pressure liquid chromatography in umbilical cord serum and in serum samples of the mother and her child as well as in the mother's milk during the first five postpartum months. Results: In the child lamotrigine serum concentrations (up to 2.8 μg ml−1) comparable to those usually achieved in active treatment with lamotrigine were found not only after birth, but also during lactation. A considerable amount of lamotrigine (2–5 mg per day) was excreted in breast milk. No adverse effects were seen in the child. Conclusion: The transfer of lamotrigine taking place during pregnancy and lactation should not be neglected. In this case the child should be thoroughly observed for potential adverse effects.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1442-9993
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The biodiversity of macrofungi in mature and young regrowth Tasmanian wet forests is described at the species level and at the community level. The macrofungal communities studied were much more species-rich than their vascular plant counterparts, with the total number of macrofungal taxa outnumbering vascular plants by four to one. This ratio applied in both mature and young regrowth forest sites. Some 242 taxa of macrofungi were recorded, of which 132 were identified to species level, the remainder to species groups or higher taxa. Distinct communities could be discerned from multivariate analysis (ordination and classification) of vascular plant and macrofungal data from the mature and regrowth sites. The two vascular plant communities had different fire histories, and this difference is also assumed to account for the separation of the macrofungal communities of the two forest types. There was generally a high level of congruence between the vascular plant and the macrofungal communities. However, one young regrowth site, which was relatively close to the mature sites in the ordination space for the analysis of vascular plants, was distant from the mature forest sites for the analysis of macrofungi. Another regrowth site, which had experienced wildfire rather than silvicultural regeneration, clustered with mature sites for some analyses of the macrofungal assemblage. Variation in the macrofungal communities was correlated with a different set of the measured environmental variables than was variation in the vascular plant communities. Mature and young regrowth forests were found to have distinctly different macrofungal floras, with approximately 40% of the taxa in each forest type being restricted to that type of site. Suitable indicator taxa (restricted or preferential to particular forest types) for use in further studies are suggested.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Ethanol levels in Drosophila breeding sites in seepages of unfortified wine inside wineries have been found to be similar to those in many decaying fruits and vegetables. Fortified wine seepages inside wineries have ethanol levels on average three times as high as other breeding sites. However there was no evidence that this variation in ethanol levels was associated with differences in Adh F frequencies in D. melanogaster at sites either within wineries or outside wineries. D. simulans was at lower frequencies at sites inside wineries compared to sites outside although this difference may not be related to ethanol levels. It is concluded that adaptation to natural levels of environmental ethanol by D. melanogaster does not necessarily modify Adh frequencies.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 38 (2000), S. 479-485 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. A Department of the Interior (DOI) irrigation drainwater study of the Uncompahgre Project area and the Grand Valley in western Colorado revealed high selenium concentrations in water, sediment, and biota samples. The lower Gunnison River and the Colorado River in the study area are designated critical habitat for the endangered Colorado pikeminnow (Ptychocheilus lucius) and razorback sucker (Xyrauchen texanus). Because of the endangered status of these fish, sacrificing individuals for tissue residue analysis has been avoided; consequently, little information existed regarding selenium tissue residues. In 1994, muscle plugs were collected from a total of 39 Colorado pikeminnow captured at various Colorado River sites in the Grand Valley for selenium residue analysis. The muscle plugs collected from 16 Colorado pikeminnow captured at Walter Walker State Wildlife Area (WWSWA) contained a mean selenium concentration of 17 μg/g dry weight, which was over twice the recommended toxic threshold guideline concentration of 8 μg/g dry weight in muscle tissue for freshwater fish. Because of elevated selenium concentrations in muscle plugs in 1994, a total of 52 muscle plugs were taken during 1995 from Colorado pikeminnow staging at WWSWA. Eleven of these plugs were from fish previously sampled in 1994. Selenium concentrations in 9 of the 11 recaptured fish were significantly lower in 1995 than in 1994. Reduced selenium in fish may in part be attributed to higher instream flows in 1995 and lower water selenium concentrations in the Colorado River in the Grand Valley. In 1996, muscle plugs were taken from 35 Colorado squawfish captured at WWSWA, and no difference in mean selenium concentrations were detected from those sampled in 1995. Colorado River flows during 1996 were intermediate to those measured in 1994 and 1995.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 25 (1993), S. 67-71 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The storage characteristics of selenate, selenite, and selenomethionine in low and high ionic strength water were investigated. Each water matrix, which contained all three selenium forms, was subjected to three different selenium concentrations (10, 50, and 100 ppb), two different container materials (borosilicate glass and high density polyethylene), and two temperatures (glass: 4°C; polyethylene: −20°C) over a period of 120 days. Ligand exchange chromatography using copper chelex was used to separate organic from inorganic selenium forms. Selenomethionine was most stable over the duration of the study, with virtually no significant influence from temperature, species concentration, container material, or water matrix. For inorganic selenium forms, significant changes in selenite were observed over 120 days, although less change was observed for solutions stored in glass. Selenate losses were observed from solutions stored under conditions of a low ionic strength matrix, polyethylene container, and freezing. Overall, the least changes among the three selenium species were observed from solutions stored in glass at 4°C.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Metals enter the Upper Sacramento River above Redding, California, primarily through Spring Creek, a tributary that receives acid-mine drainage from a US EPA Superfund site known locally as Iron Mountain Mine. Waterweed (Elodea canadensis) and aquatic insects (midge larvae, Chironomidae; and mayfly nymphs, Ephemeroptera) from the Sacramento River downstream from Spring Creek contained much higher concentrations of copper (Cu), cadmium (Cd), and zinc (Zn) than did similar taxa from nearby reference tributaries not exposed to acid-mine drainage. Aquatic insects from the Sacramento River contained especially high maximum concentrations of Cu (200 mg/kg dry weight in midge larvae), Cd (23 mg/kg dry weight in mayfly nymphs), and Zn (1,700 mg/kg dry weight in mayfly nymphs). Although not always statistically significant, whole-body concentrations of Cu, Cd, and Zn in fishes (threespine stickleback, Gasterosteus aculeatus; Sacramento sucker, Catostomus occidentalis; Sacramento squawfish, Ptychocheilus grandis; and chinook salmon, Oncorhynchus tshawytasch) from the Sacramento River were generally higher than in fishes from the reference tributaries.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 14 (1985), S. 363-388 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract As a continuing part of the National Contaminant Biomonitoring Program, the U.S. Fish and Wildlife Service collected freshwater fish at 112 monitoring stations in 1978–1979 and 1980–1981. Three composite samples of three to five fish were collected at each of about half of the stations in odd-numbered years and at the other half in even-numbered years, and analyzed for lead, mercury, cadmium, arsenic, selenium, cooper, and zinc. The geometric means, minimum, and maximum of elemental concentrations (μg/g wet weight) during 1978–1979 and (in parentheses) during 1980–1981 were as follows: Pb 0.19, 0.10–6.73 (0.17, 0.10–1.94); Hg 0.11, 0.01–1.10 (0.11, 0.01–0.77); Cd 0.04, 0.01–0.41 (0.03, 0.01–0.35); As 0.16, 0.04–2.08 (0.14, 0.05–1.69); Se 0.46, 0.09–3.65 (0.47, 0.09–2.47); Cu 0.86, 0.29–38.75 (0.68, 0.25–24.10); and Zn 25.63, 7.69–168.1 (23.82, 8.82–109.2). The 85th percentile, calculated for station mean concentrations (μg/g wet weight) for 1978–1979 and 1980–1981, respectively, were: Pb 0.32 and 0.25; Hg 0.18 and 0.18; Cd 0.09 and 0.06; As 0.23 and 0.22; Se 0.70 and 0.71; Cu 1.14 and 0.90; and Zn 46.26 and 40.09. There was no significant upward or downward trend between collection periods of the national geometric means of any of the elements except for cooper which decreased significantly. Species differences in elemental concentrations contributed more variability to the data set than did station differences. The proportion of the collections composed of each species changed little between collection periods. Thus, the magnitude of the species effect on the national geometric mean of each period was probably fairly consistent; however, it precludes our making sound comparisons among various regions of the United States. As a participant in the National Contaminant Biomonitoring Program (NCBP), the U.S. Fish and Wild-life Service is responsible for monitoring temporal and geographic trends of organochlorine chemical and elemental contaminants in the nation's fresh-water fish, European starlings (Sturnus vulgaris), and waterfowl. Primary emphasis has been placed on organochlorine chemical contaminants; however, certain elements have been measured intermittently and additional elements have been added periodically since 1969. We summarize the concentrations of the seven elements—lead, mercury, cadmium, arsenic, selenium, copper, and zinc—measured in freshwater fish collected during 1978–1981. Data for earlier collections have appeared in other reports (Hendersonet al. 1972; May and McKinney 1981; Walshet al. 1977).
    Type of Medium: Electronic Resource
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