Electronic Resource
Oxford, UK
:
Blackwell Science Ltd
Haemophilia
4 (1998), S. 0
ISSN:
1365-2516
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary. Inhibitor development is now the main complication of replacement therapy in haemophilia A. Given that most severely affected patients make no detectable factor VIII, it is perhaps surprising that only ˜30% actually mount an immune response to factor VIII as a foreign antigen. Those that do mostly have major factor VIII gene lesions. The association of HLA genotype with inhibitors in patients with identical mutations is weak. Environmental factors may be more important than genetic in antibody response to factor VIII.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1365-2516.1998.440543.x
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