ISSN:
1573-9007
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Encephalographic correlates of behavioral activity were demonstrated for oligopeptides belonging to the group of memory neuromodulators and of a similar nature: arginine-vasopressin, corticotrophic fragment ACTH4–7 and its four analogs, leu-enkephalin, and a melanostatin analog. The compounds activated the EEG, the number of low-frequency components in the spectrum was reduced and the number of high-frequency components increased, and the amplitude of the waves was reduced in most cases, The results of a study of the effect of ACTH4–7 and vasopressin on the parameters of the visual global evoked potential show that, depending on their dose, neuropeptides can reduce the latent period and increase the amplitude of the global potential or, conversely, in a substantially increasing dose they may inhibit these parameters. Effects of vasopressin are long-term in nature and may continue for weeks, whereas the effect of ACTH fragments and leuenkephalin are limited to a few hours.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01060233
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