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  • 1
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 32 (1960), S. 651-655 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 66 (1944), S. 914-918 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During blood circulation statistically significant alterations of clotting factor activities, thrombin time and fibrin polymerization time are observed. In relation to the blood from the right heart the activity of factor VIII increases with each passage of a capillary system. Prothrombin and factor X on the other hand show a decrease in activity. Thrombin time and fibrin polymerization time become longer. All these changes are obviously fully reversible by a passage through the liver. Thrombocyte counts behave differently. They are highest in the vena cava (blood from the bone marrow). The most marked changes of all parameters are seen in the renal venous blood.
    Notes: Zusammenfassung Bei der Kreislaufpassage des Blutes kommt es zu statistisch signifikanten Veränderungen der Aktivitäten von Gerinnungsfaktoren, der Thrombinzeit und der Fibrinpolymerisationszeit. Ausgehend vom Mischblut des rechten Herzens nimmt der Faktor VIII bei Passage eines jeden Capillargebietes an Aktivität zu. Prothrombin und Faktor X nehmen dagegen an Aktivität ab. Thrombinzeit und Fibrinpolymerisationszeit werden länger. Alle diese Veränderungen kehren sich offensichtlich bei der Leberpassage wieder um. Die Thrombocytenzahlen verhalten sich anders. Sie sind in der Vena cava am höchsten (Blut aus dem Knochenmark). Für alle Parameter finden sich die stärksten Veränderungen im Nierenvenenblut.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 35 (1957), S. 1053-1058 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurde bei 63 adipösen Patienten eine Entfettung mit dem Schilddrüsenhormon Trijodthyronin durchgeführt. Die erzielten Gewichtsabnahmen sind beträchtlich, die Verträglichkeit des verwendeten Präparates ausgezeichnet. Vor und während der Behandlung wurden Grundumsatz, Serumcholesterin, Jodavidität der Schilddrüse sowie bei 15 Patienten die N-Bilanz und bei 18 Patienten die Ausscheidungen von Natrium, Kalium, anorganischem Phosphor und Chlorid kontrolliert. Durch die Therapie kam es zu den erwarteten Grundumsatzsteigerungen, Serumcholesterinsenkungen und, von wenigen Fällen abgesehen, zu einer ausgesprochenen Senkung der Jodavidität der Schilddrüse. Die Urinausscheidung von Gesamtstickstoff, Natrium, Chloriden und anorganischem Phosphat wurden durch die Behandlung signifikant vermehrt, die des Kaliums sowie die Stuhlstickstoffausscheidung nicht nennenswert verändert. Die beschriebenen Mehrausscheidungen werden diskutiert.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 7 (1974), S. 429-432 
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; retard formulations ; retard quotients ; sustained release ; half-value duration ; dibenzepin hydrochloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In vivo criteria are proposed for the assessment of retard formulations. If the pharmacokinetics of the retard formulation tested and of the normal preparation are known, in either plasma or urine, two retard quotients can be defined which define the sustained release. One of the quotients refers to the width (half-value duration) and the other to the height of the plasma concentration time curve of the retard form as compared to the conventional preparation. From these criteria it is possible to draw useful conclusions about thein vivo quality of a retard formulation in an early stage of development of the dosage form. As a practical example the criteria have been applied to Noveril® 240 tablets (dibenzepin hydrochloride), the retard effect of which has made it possible to reduce the frequency of administration from three times daily to once a day.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 22 (1982), S. 247-251 
    ISSN: 1432-1041
    Keywords: liver disease ; pindolol ; antipyrine clearance ; elimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The elimination of pindolol was studied in 32 patients suffering from various liver diseases, mainly acute hepatitis and hepatic cirrhosis. The total body clearance of antipyrine was measured simultaneously as a parameter of liver microsomal enzyme activity. The doses given were antipyrine 1000 mg orally and pindolol 3 mg i.v. Plasma samples were taken and urine was collected for up to 72 h for the measurement of drug concentrations. In addition, conventional biochemical laboratory tests were done. The total body clearance of antipyrine was compared with the pharmacokinetic parameters calculated for pindolol, and the results of the biochemical tests. No correlation was found between antipyrine clearance and the routine biochemical parameters in liver disease or with the total body clearance of pindolol. A significant correlation was seen with the nonrenal clearance of pindolol taken as representing its major metabolic degradation. Higher correlation coefficients were observed when two subgroups of patients with acute hepatitis and hepatic cirrhosis were separated. In some patients suffering from hepatic cirrhosis a higher urinary excretion of unchanged pindolol was observed as liver function become decompensated, a finding due to an unknown mechanism but based on intact renal function. In patients with acute hepatitis a much higher nonrenal clearance was found than in many other patients, which might be based on increased liver blood flow.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 22 (1982), S. 423-428 
    ISSN: 1432-1041
    Keywords: pindolol ; renal failure ; metabolism ; pharmacokinetics ; 14C-pindolol ; blood metabolites ; urinary metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Increased metabolism of pindolol in renal impairment has previously been suggested by pharmacokinetic calculations. The present study was a pharmacokinetic and metabolic investigation in 7 patients with severe renal impairment (endogeneous creatinine clearance below 5 ml/min). All the patients received pindolol 5 mg t.d.s. 5 days. On the sixth day, after an overnight fast, 14C-pindolol 5 mg was given orally as a solution to drink. Blood samples were taken for up to 72 h and urine was collected at intervals up to 96 h for measurement of unchanged pindolol by a fluorimetric method and total radioactivity by liquid scintillation counting. Metabolites in blood and urine were analysed after separation by HPLC. It was found that the plasma levels following a single dose of 14C-pindolol were similar to those observed in healthy volunteers, but the elimination half-life was slightly increased up to 11.5 h. The observed steady state plasma concentrations of pindolol were twice as high but they are still in the therapeutic range of 10 to 100 ng/ml. Therefore, the dose of pindolol could have been reduced by a factor 2, but the reduction was not essential. No active metabolite of pindolol was found in plasma or urine, but elimination of the metabolites was decreased. The elimination half-life following multiple doses was prolonged compared to normal and it was quite comparable to that found for the pharmacodynamic half-life in renal patients. The discrepancy between the present findings and the previous results for metabolism and pharmacodynamic half-life was probably due to the sensitivity of the fluorimetric assay of pindolol.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 44-46 (July 1995), p. 97-126 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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