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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 26 (2000), S. 68-99 
    ISSN: 1432-0541
    Keywords: Key words. Rectilinear Steiner trees, Algorithms, Dynamic programming, Worst-case analysis, Random instances, implementation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. The rectilinear Steiner tree problem asks for a shortest tree connecting given points in the plane with rectilinear distance. The best theoretically analyzed algorithms for this problem are based on dynamic programming and have a running time of O(n 2 . . . 2.62 n ) (Ganley and Cohoon), resp. $n^{O(\sqrt{n})}$ (Smith). The first algorithm can solve problems of size 27, the second one is highly impractical because of the large constant in the exponent. The best implementations perform poorly even on small problem instances; the best practical results can be reached using a Branch \& Bound approach (Salowe and Warme); this implementation can solve random problems of size 35 within a day, while the dynamic programming approach of Ganley and Cohoon can handle only 27 point examples. In this paper we improve the theoretical worst-case time bound to O(n 2 . . . 2.38 n ) , for random problem instances we prove a running time of α n with a constant α 〈 2 . We have implemented our algorithms and can now solve problems of 40 points in a day using a provably good dynamic programming approach, and can solve problems of 55 points with a Branch \& Bound strategy. For exponential-time algorithms, this is an enormous improvement.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 162 (1981), S. 281-299 
    ISSN: 1432-0568
    Keywords: Ratite birds ; Epididymis ; Main part ; Appendix epididymidis ; Rete testis ; Ductuli efferentes (genesis and structure)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The epididymis of ratitae is subdivided into a main part and an appendix epididymidis. The appendix epididymidis consists of the ductus aberrans and ductuli aberrantes. The ductus aberrans is the cranial continuation of the ductus epididymidis. The appendix epididymidis is cranially attached to the adrenal gland. In the main part of the epididymis the largest part of the rete testis is found. The rete testis is composed of an intratesticular rete (also named tubuli recti), an intracapsular rete (with a longitudinal cistern and a true rete), and an extratesticular rete (predominantly consisting of approximately 20 longitudinal channels). The rete testis develops most likely embryonally from buds of the glomerular capsules of the mesonephros. The ductuli efferentes proximales also arise from these capsules, while the ductuli efferentes distales develop from the proximal and distal tubules and intermediate-segments of the mesonephros. The ductus epididymidis originates from the Wolffian duct and meanders dorsolaterally through the epididymis.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Key words Human immunodeficiency virus-1 ; Cytotoxic T lymphocyte ; Altered peptide ligand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The propensity of HIV-1 for genetic variation, a consequence of error-prone reverse transcription combined with high rates of replication, is thought to contribute to the establishment of persistent infection in the host despite the presence of a vigorous antiviral immune response. Protective immunity to viruses is mediated primarily by cytotoxic T lymphocytes, which recognize viral peptides of 8–11 amino acids bound to major histocompatibility complex class I molecules on the surface of infected cells. In this review we examine the mechanisms by which mutation within peptide antigen-encoding regions of the viral genome enables HIV-1 to evade recognition by virus-specific cytotoxic T lymphocytes. The discussion is relevant to other genetically unstable viruses and more generally to intracellular pathogens of variable antigenicity.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 160 (1993), S. 432-439 
    ISSN: 1432-072X
    Keywords: Nitrous oxide reduction ; Dinitrogen formation ; Denitrification ; NOx-production ; Nitrate dissimilation ; Escherichia coli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Escherichia coli K12 reduces nitrous oxide stoichiometrically to molecular nitrogen with rates of 1.9 μmol/h x mg protein. The activity is induced by anaerobiosis and nitrate. N2+formation from N2O is inhibited by C2H2 (K i ∼ 0.03 mM in the medium) and nitrite (K i=0.3 mM) but not by azide. A mutant defective in FNR synthesis is unable to reduce N2O to N2. The reaction in the wild type could routinely be followed by gas chromatography and alternatively by mass spectrometry measuring the formation of 15N2 from 15N2O. The enzyme catalyzing N2O-reduction in E. coli could not be identified; it is probably neither nitrate reductase nor nitrogenase. E. coli does not grow with N2O as sole respiratory electron acceptor. N2O-reduction might not have a physiological role in E. coli, and the enzyme involved might catalyze something else in nature, as it has a low affinity for the substrate N2O (apparent K m∼3.0 mM). The capability for N2O-reduction to N2 is not restricted to E. coli but is also demonstrable in Yersinia kristensenii and Buttiauxella agrestis of the Enterobacteriaceae. E. coli is able to produce NO and N2O from nitrite by nitrate reductase, depending on the assay conditions. In such experiments NO inf2 sup- is not reduced to N2 because of the high demand for N2O of N2O-reduction and the inhibitory effect of NO inf2 sup- on this reaction.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0649
    Keywords: 34.50Gb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Radiative emission in the NO γ-band system occurs when air at a few Torr initial pressure is shock-heated at sufficiently high temperatures of 3500–7000 K. Emission spectra of this system in shocks indicate that collisional quenching of the emitting A 2Σ+ state is a critical quantity controlling the intensity. Quenching of excited NO by NO itself has been measured using direct time decay of laser-induced fluorescence in the shock tube at 3500 K. The cross section (2−σ error) is 59±20 Å2, compared to the room temperature value 37±8 Å2. At 3500 K, N2 also quenches NO with a cross section ∼2 Å2, much larger than the value at 300 K.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0649
    Keywords: 34.50
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract State-to-state rotational energy transfer (RET) co-efficients were determined for inelastic collisions of OH (A 2Σ+, v′=0) with N2, CO2, and H2O at 300 K. The experimental procedure described previously allows the direct evaluation of state-specific RET coefficients from time-resolved laser-induced fluorescence (LIF) measurements without any assumptions on the RET. The results show strikingly different RET behaviour for the three collision partners. The data can serve as a basis for a comparison with dynamic collision models.
    Type of Medium: Electronic Resource
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  • 9
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 34:7 (1986) 628 
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  • 10
    ISSN: 0942-0940
    Keywords: Keywords: Compliance; infusion test; normal pressure hydrocephalus; resistance.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The internationally accepted calculation methods concerning cerebrospinal fluid dynamics proceed from a pressure independent resistance to cerebrospinal fluid outflow. In a new model we focus our attention on the pressure dependency of resistance. In our calculation model we are monitoring the complete pressure course p(t) over the time during and after the infusion. The comparison of the pressure rise On(p) during the infusion and the descent Off(p) after the infusion at the same pressure level allows one to construct all formulas for the compliance C(p) and resistance R(p). The computerized analysis of the results of the intrathecal infusion test using our mathematical computation leads to a simplification of this investigation. The simultaneous measurement of the resistance and compliance during a single investigation allows one to minimize the patient's discomfort. In contrast to the classical methods it is not necessary that the ICP reaches a plateau.  Our mathematical method diverges with the description of a pressure dependent slope of the function for the resistance from the static examination models. For that we are able to take the non-linearity of the cerebrospinal fluid resorption into consideration.
    Type of Medium: Electronic Resource
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