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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mineralium deposita 32 (1997), S. 371-381 
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract During the last decade, exploration and mining of modern-Tertiary heavy mineral beach and raised beach sands along the west coast of South Africa has developed into a major industry. High resolution radiometric techniques have demonstrated their use as a quantitative indicator of total heavy mineral concentration (THM) and also have the ability to discriminate between sediments derived from different provenance terrains. Results indicate that it is possible to calculate the total heavy mineral concentration from high resolution radiometric measurements, but the ability to quantify the concentration of individual mineral fractions, such as ilmenite, requires further refinement of the method. Radiometric characteristics of the light mineral fraction made it possible to distinguish between sediments from mixed marine-aeolian palaeoplacers and active present beach placers. The effects of in situ alteration of the ilmenite fraction in the palaeoplacers were also reflected by subtle contrasts in the radiometric character of the deposits. Furthermore, the uniform radiometric character of the sample population indicates a common provenance for the heavy mineral suite and supports previous results which indicate the metamorphites of the mid-Proterozoic Namaqua Province as the primary source terrain. The high resolution radiometric techniques discussed offer a broad spectrum of applications in sedimentology and have the potential to aid heavy mineral exploration. With further refinement it can possibly be used quantitatively in grade control during mining and beneficiation of heavy mineral deposits.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Hypersensitivity to cow milk protein is frequently observed in infancy. Since the pH in the infant's stomach is relatively high (pH 3–4) compared with adults (pH 2). an incomplete digestion of the milk proteins is expected to occur.Objective The determination of the degree of hydrolysis by pepsin of the four main proteins of bovine whey. i.e. α-lactalbumin (αLa). β-lactoglobulin (βLg). bovine serum albumin (BSA) and bovine immunoglobulin G (B-IgG). in the pH range 2.0- 4.0 and of the antigenic properties of the resulting hydrolysates.Methods Whey proteins were successively hydrolysed with pepsin at pH values ranging from 2.0 to 4.0 and with pancreatic enzymes at pH 7.5 using a pH-stat. The resulting hydrolysates were characterized by their degree of hydrolysis, and analysed by sodium dodecyl sulfale polyacrylamide gel electrophoresis, gel permeation chromatography and immunologically by competitive enzyme-linked immunosorhent assay.Result In general, the degree of hydrolysis, the gel electrophoretic patterns, the contents of peptides of molecular mass 〉 5kDa and the residual hurnan-immunoglohulin E and G antigenicities of the hydrolysates did not differ much whether the pepsin incubation was done at pH 2.0 or 3.0. Pepsin incubation at pH 4.0. however, resulted in a decreased hydrolysis and enhanced residual antigenicity of αLa, BSA and B-IgG. but not of βLg.Conclusion The poor and slow degradation of the antigenic epitopes of whey proteins when pepsin digestion occurs under conditions that prevail in the stomach of infants could be of much importance for the development of cow milk hypersensitivity. The immature gastrointestinal mucosal barrier of infants allows large antigenic fragments of these proteins to pass into the systemic circulation.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background There is a large variability in clinical response to corticosteroid treatment in patients with asthma. Several markers of inflammation like eosinophils and eosinophil cationic protein (ECP), as well as exhaled nitric oxide (NO), are good candidates to predict clinical response.Aim We wanted to determine whether we could actually predict a favourable response to inhaled corticosteroids in individual patients.Methods One hundred and twenty patients with unstable asthma were treated with either prednisolone 30 mg/day, fluticasone propionate 1000 µg/day b.i.d. or fluticasone propionate 250 µg/day b.i.d., both via Diskhaler. They were treated during 2 weeks, in a double-blind, parallel group, double dummy design. We measured eosinophils and ECP in blood and sputum, and exhaled nitric oxide as inflammatory parameters before and after 2 weeks in order to predict the changes in forced expiratory volume in 1 s (FEV1), provocative concentration of methacholine causing a 20% fall in FEV1 (PC20 Mch), and asthma quality of life (QOL). Secondly, to test whether these results were applicable in clinical practice we determined the individual prediction of corticosteroid response.Results We found that changes in FEV1, PC20 Mch and QOL with corticosteroids were predominantly predicted by their respective baseline value and to a smaller extent by eosinophils in blood or sputum. ECP, measured in blood or sputum, was certainly not better than eosinophils in predicting clinical response to corticosteroids. Smoking status was an additional predictor for change in FEV1, but not for change in PC20 Mch or QOL. Prediction of a good clinical response was poor. For instance, high sputum eosinophils (≥ 3%) correctly predicted an improvement in PC20 Mch in only 65% of the patients.Conclusion Our findings show that baseline values of the clinical parameters used as outcome parameters are the major predictors of clinical response to corticosteroids. Eosinophil percentage in blood or sputum adds to this, whereas ECP provides no additional information. Correct prediction of clinical response in an individual patient, however, remains poor with our currently used clinical and inflammatory parameters.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Oecologia 77 (1988), S. 268-272 
    ISSN: 1432-1939
    Keywords: Cs/K ratio ; Active/stable Cs ; Mushroom species ; Selective resorption ; Seasonal changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Uptake of 134Cs, 137Cs and 40K is determined by gamma-ray spectroscopy for samples of fungi and humus. For these samples also the stable Cs content is determined by atomic absorption spectrophotometry. The fungi resorpted only the alkali metals and none of the other fission products from the Chernobyl accident. The measurements show a large variation in space and time for fungi of the same species in the stable and radioactive cesium content. Compared to this variation the variation between the different species is in general small. Cs content in mycorrhizal fungi is in general higher than in saprophytic fungi, but differences in absorption in saprophytic and mycorrhizal fungi could not be confirmed. The assumption that certain saprophytic fungi mainly grow in either litter, fermentation or humus layer is not supported by this experiment.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-601X
    Keywords: 25.40.Sc ; 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have studied the fragmentation of Au projectiles interacting with targets of C, Al and Cu at an incident energy ofE/A=600 MeV. The employed inverse kinematics allowed a nearly complete detection of projectile fragments with chargeZ≧2. The recorded fragmentation events were sorted according to three observables, the multiplicityM lp of light charged particles, the largest atomic numberZ max within an event, and a new observable,Z bound, representing the sum of the atomic numbersZ of all fragments withZ≧2. Using these observables, the impact parameter dependence of the fragmentation process was investigated. For all three targets, a maximum mean multiplicity of 3 to 4 intermediate mass fragments (IMFs) is observed. The corresponding impact parameters range from central collisions for theC target to increasingly peripheral collisions for the heavier targets. It is found that the correlation between the IMF multiplicity andZ bound, extending from evaporation type processes (largeZ bound) to the total disassembly of the projectile (smallZ bound), is independent of the target nucleus. This universal behaviour may suggest an — at least partial — equilibration of the projectile fragment prior to its decay.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The velocities of heavy residues with atomic numbers 〉8 were measured in the28Si +natSi reaction at 12.4 MeV/u. The analysis revealed the existence of a fully damped component peaked strongly in the beam direction. The angular and velocity distributions of this component are determined mainly by recoils from secondary emission of particles.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 324 (1986), S. 121-122 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Excitation-energy sharing has been studied in the20Ne+54Fe reaction at 11 and 15 MeV/nucleon using projectile-like fragment-α correlations. Since the dominant part of the correlation can be described by sequential decay, primary excitation distributions were obtained. An unexpected strong asymmetry in the excitation-energy sharing is observed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 12 (1989), S. 64-71 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The copper content of and radiocopper uptake in fibroblast cultures were studied to evaluate their usefulness for the diagnosis of Wilson's disease. We used methods closely related to those described in the literature, and applied these to cell lines of six patients with Wilson's disease and 12 controls. The results were: (1) The copper content of the cytosol of skin fibroblasts derived from patients with Wilson's disease was lower than that of controls when the cells were grown in a medium with a low copper concentration (0.7 µmol L−1); increased copper concentration (157 µmol L−1 in the medium failed to demonstrate any difference between normal fibroblasts and those derived from patients with Wilson's disease. (2) Radiocopper uptake studies did not differentiate between normal fibroblasts and fibroblasts from patients with Wilson's disease. We conclude that the cytosolic copper content of fibroblasts grown in a low copper medium is a potential diagnostic tool in Wilson's disease. At present not all controls can be distinguished from the Wilson cells; ways must be sought, therefore, of improving the technique.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 44 (1989), S. 83-92 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The coastal dune aquifer, providing drinking water for a large part of the population of the western Netherlands, is recharged by fainfall and artificial infiltration of Rhine water. Chernobyl fall-out has been detected in both water sources. At the Castricum lysimeter station the rainfall-derived water, draining from 2.25 m of unsaturated sandy soil, shows levels of Cs-137 around the detection limit of 20 to 40 mBq kg−1. At this site, the soil itself retained some Chernobyl-derived Cs-137 in the top 10 cm, where a similar quantity of old Cs-137 has also been retained. Penetration of old Cs-137 is deeper (up to 70 cm) under oak vegetation than in the bare soil. In the infiltration channels, fed by Rhine water, the bottom mud contains only Chernobyl-derived Cs nuclides. Radioactivity from Cs-137 is about one tenth of that from natural radioactivity due to K-40. Cesium levels are apparently unrelated to adsorptive properties.
    Type of Medium: Electronic Resource
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