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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Energy & fuels 4 (1990), S. 644-646 
    ISSN: 1520-5029
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Oil cracking—the thermal breakdown of heavy hydrocarbons to smaller ones—takes place within oil-bearing rock formations at depths commonly accessed by commercial oil wells. The process ultimately converts oil into gas and pyrobitumen, and thus limits the occurrence of petroleum and ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0851
    Keywords: Key words GM-CSF-transduced autologous melanoma vaccine ; Cerebral metastases-acute cerebral oedema ; Tumour-reactive cytotoxic T lymphocytes ; Eosinophilia ; C-reactive protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The first use of granulocyte/macrophage-colony-stimulating-factor-transduced, lethally irradiated, autologous melanoma cells as a therapeutic vaccine in a patient with rapidly progressive, widely disseminated malignant melanoma resulted in the generation of a novel antitumour immune response associated with partial, albeit temporary, clinical benefit. An initially negative reaction to non-transduced, autologous melanoma cells was converted to a delayed-type hypersensitivity (DTH) reaction of increasing magnitude following successive vaccinations. While intradermal vaccine sites showed prominent dendritic cell accrual, DTH sites revealed a striking influx of eosinophils in addition to activated/memory T lymphocytes and macrophages, recalling the histology of challenge tumour cell rejection in immune mice. Cytotoxic T lymphocytes (CTL) reactive with autologous melanoma cells were detectable at high frequency after vaccination, not only in limiting-dilution analysis, but also in bulk culture without added cytokines. Clonal analysis of CTL showed a conversion from a purely CD8+ response to a high proportion of CD4+ clones following vaccination. A prominent acute-phase response manifested by a five- to tenfold increase in C-reactive protein was observed, as was a systemic eosinophilia. Vaccination resulted in the regression of axillary lymphatic metastases, stabilisation of pulmonary metastases, and a dramatic, reversible increase in cerebral oedema associated with multiple central nervous system metastases; however, lesions in the adrenal glands, pancreas and spleen proved refractory. The antitumour effects and immune response were not detectable 2 months following the last vaccination. Irradiation of the extensive cerebral metastases resulted in rapid deterioration and death of the patient.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 19 (1995), S. 343-345 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a préconisé des résections larges avec des marges entre trois et cinq centimètres depuis bientôt 140 ans. Ces rapports concernaient tous les stades confondus et n'intéressaient pas les stades précoces. Breslow le premier a rapporté de bons résultats avec des résections limitées de ces mêmes tumeurs. Nous résequons les mélanomes quelle que soit leur épaisseur, avec une marge de sécurité de 1.0 à 1.5 cm (plutôt 1.0) depuis 1975. Nous recommandons une résection avec une marge de sécurité de 1.0 cm quelle que soit son épaisseur. Clark a démontré que le mélanome envahit verticalement, argument qui à priori serait en faveur d'une excision en profondeur plutôt qu'en largeur au plan anatomopathologique. Deux études ont montré qu'il n'y avait aucune différence de récidive locorégionale ou de mortalité en cas de résection avec marges limitées. Ce n'est pas pour autant une intervention qui se fait en cabinet, mais qui doit se pratiquer méticuleusement en salle d'opération sous anesthésie légère.
    Abstract: Resumen La resección amplia de un melanoma con márgenes de 3 a 5cm, ha sido preconizada en la literature por cerca de 140 años. Los informes publicados agrupan pacientes en todos los estadíos, y no realmente la enfermedad en su estado precoz. Breslow fue quien primero publicó buenos resultados de la resección con márgenes limitados. Nuestro grupo ha venido resencando los melanomas de todos los espesores con un margen limitado (1.00 a 1.50 cm, más frecuentemente 1.0 cm) desde 1975. Nuestra política es un margen de resección de 1cm, no importa cual sea el espesor del tumor. Clark ha demonstrado que el melanoma se extiende de manera vertical y que, por consiguiente, desde el punto de vista histopatológico uno debe ser generoso en lo referente a profundidad más que a extensió. Dos estudios han demostrado que no existe diferencìa en cuanto a recurrencia localregional y que tampoco varían las tasas de mortalidad cuando se emplean márgenes más conservadores. Le resección del melanoma no es un procedimiento de consultorio, sino una operación para ser realizada en forma meticulosa en un quirófano, de preferencia bajo anestesia general.
    Notes: Abstract Wide local excision for melanoma with margins of 3 to 5 cm have been advocated in the literature for nearly 140 years. These reports have grouped all stages of melanoma rather than addressing primary early stage disease. Breslow first advocated limited excision margins for these tumors. We have been excising all thicknesses of melanoma with a limited margin (1.00–1.50 cm, mostly 1.00 cm) since 1975. We advocate a 1 cm excision margin irrespective of tumor thickness. Clark has shown that melanoma invades in a vertical fashion, and thus one would expect to be more generous in depth than in width on a pathologic basis. Two studies have shown that there is no difference in the increase in locoregional recurrence and no change in death rate from the disease with more conservative treatment margins. Excision of this lesion is not an office procedure. It should be performed meticulously in an operating room, preferably under light general anesthesia.
    Type of Medium: Electronic Resource
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