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  • 1
    Electronic Resource
    Electronic Resource
    Passage of inulin andp-aminohippuric acid through artificial membranes: Implications for measurement of renal function (1975)
    Springer
    The journal of membrane biology 20 (1975), S. 347-363 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Diffusion of inulin andp-aminohippuric acid (PAH) in combined aqueous solution through artificial membranes was measured at room temperature and atmospheric pressure. The membranes had pore diameters of 26, 50, 100, 200, 250, 350, 510 or 990 Å. The diffusion of PAH was only restricted with a pore size of 26 Å, but inulin diffusion was restricted at 100 Å. When diffusion of both solutes was unrestricted (pore diameter ≧200 Å), PAH diffused four times faster than inulin, and in restricted situations this ratio was even greater. The results of these diffusion studies allow the major and minor molecular dimensions of the solutes to be estimated. Filtration of the two solutes was studied in slowly flowing situations and also with increased temperature and pressure. Pore sizes required for unrestricted filtration were the same as for unrestricted diffusion but the passage ratio was reduced from 4 to 2. These results suggest strongly that two conditions are necessary if the glomerular filtration rate (GFR) of inulin is to equal the true GFR: membrane pore size must be at least 200 Å and passage through the membranes must be by bulk transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870643
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  • 2
    Electronic Resource
    Electronic Resource
    The molecular configuration of inulin: Implications for ultrafiltration theory and glomerular permeability (1977)
    Springer
    The journal of membrane biology 34 (1977), S. 93-101 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary A space-filling model of the inulin molecule, based solely on physico-chemical data in the literature, indicates that the gross shape of the solvated molecule is a cylinder having semi-length 25 Å and radius 10 Å. The axial dimensions of this model very nearly equal the equivalent estimates (25 and 10.5 Å) previously determined by studying restricted passage of inulin through artificial membranes of known pore size (E. Middleton,J. Membrane Biol. 20:347, 1975). The good agreement between these independentin-vitro studies-neither of which depends on ultrafiltration theory-strongly suggests that glomerular pore size is considerably greater than predicted by the theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870295
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  • 3
    Electronic Resource
    Electronic Resource
    The effective configuration of a molecule in ultrafiltration: Its definition and determination (1979)
    Springer
    The journal of membrane biology 47 (1979), S. 129-143 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The time taken to descend through a measured depth of glycerol was recorded for some metal boxes, cylinders, ellipsoids and spheres having axial ratios from 0.2 to 2.4. The results were used to determine the relation between each nonspherical form, its axial ratio, and the radius of its dynamically equivalent sphere with respect to glycerol. Expressed in dimensionless terms, these relations closely predict thereal gross configuration of four regularly shaped molecules (inulin, ribonuclease, hemoglobin and hen egg-white lysozyme), and sensibly predict theeffective gross configuration of one irregularly shaped molecule (γGl immunoglobulin) from their known axial ratios and Stokes-Einstein radii. Similarly, they predict theeffective gross configuration of a molecule whose real shape is not known (serum albumin). Since the relations established for the models apply to all the molecules considered, it seems likely that they can be used in conjunction with membrane-diffusion studies (E. Middleton, 1975,J. Membrane Biol. 20:347) and free-diffusion studies to determine the effective configuration in ultrafiltration of any molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876113
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  • 4
    Electronic Resource
    Electronic Resource
    Longitudinal effects of pregnancy on the pharmacokinetics of theophylline (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 289-295 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; pregnancy ; pharmacokinetics ; lactation ; methylxanthines ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of pregnancy on the disposition of theophylline were assessed in 10 patients throughout pregnancy and post-partum. The clearance relative to total theophylline concentrations was only slightly affected during the first two trimesters (2.61±0.63 l/h and 2.85±1.05 l/h), while a statistically significant reduction was evident late in pregnancy (2.05±0.49 l/h). Post-partum clearance values (2.16±2.81 l/h) suggest an ongoing suppression relative to pre-pregnancy levels. A similar pattern was evident with clearance values based on free theophylline plasma concentrations (p=0.12). Absolute volume of distribution increased in concert with gestation, suggesting that theophylline partitions into the enlarged tissue spaces. In addition, theophylline binding to plasma proteins decreased, albeit insignificantly, during the second (fraction bound=29%) and third (32%) trimesters compared to post-partum values (41%). Increases in half-life during the third trimester (13.00±2.31 h vs 9.53±3.53 h post-partum) were highly significant. This change reflects the net effect of reduced clearance and increased distribution. Breast feeding had no effect on the disposition of theophylline, although the transfer of this compound into breast milk was confirmed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607577
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  • 5
    Electronic Resource
    Electronic Resource
    The preference for variety
    Amsterdam : Elsevier
    The @Journal of Behavioral Economics 16 (1987), S. 49-54 
    Details
    ISSN: 0090-5720
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0090-5720(87)90005-2
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  • 6
    Electronic Resource
    Electronic Resource
    Random utility and the preference for variety
    Amsterdam : Elsevier
    Journal of Socio-Economics 20 (1991), S. 227-233 
    Details
    ISSN: 1053-5357
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1053-5357(91)90002-B
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  • 7
    Electronic Resource
    Electronic Resource
    Prostaglandin E and mitogenic stimulation of human lymphocytes in serum-free medium
    Amsterdam : Elsevier
    Prostaglandins 15 (1978), S. 423-427 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(78)90125-9
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  • 8
    Electronic Resource
    Electronic Resource
    Occlusion of Water by Potassium and Sodium Chlorides (1934)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 6 (1934), S. 314-316 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50091a004
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  • 9
    Electronic Resource
    Electronic Resource
    Adsorption by Precipitates. II (1920)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 24 (1920), S. 30-73 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150199a003
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  • 10
    Electronic Resource
    Electronic Resource
    Adsorption by Precipitates. III (1920)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 24 (1920), S. 630-663 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150206a004
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