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  • 1
    Electronic Resource
    Electronic Resource
    Glycosaminoglycans in human cerebral tumors (1982)
    Springer
    Acta neuropathologica 57 (1982), S. 299-305 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral tumors ; GAGs ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence and the distribution of GAGs have been studied histochemically in 224 human cerebral tumors by means of Alcian blue techniques. In the normal peritumoral gray matter the alcianophilia is stronger than in the white matter and demonstrated the presence of HA and CS. In the glioma group the alcianophilia, due to HA and CS, is mainly related to the presence of infiltrated cortex. In the other tumors, GAGs are histochemically disclosed in relation to collagen, reticulin, mesodermic areas, etc. The vessels of every tumor show a positive staining for HA, CS, and HS. The histochemical findings are consistent with the biochemical ones as reported in Part I, even though the significance of GAGs in cerebral tumors remains unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692187
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  • 2
    Electronic Resource
    Electronic Resource
    GFAP, FVIII/RAg, Laminin, and fibronectin in gliosarcomas: An immunohistochemical study (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 108-116 
    Details
    ISSN: 1432-0533
    Keywords: Gliosarcoma ; Immunohistochemistry ; GFAP ; Factor VIII/RAg ; Laminin ; Fibronectin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary GFAP, Factor VIII/RAg, laminin, and fibronectin were immunohistochemically investigated in 15 glioblastomas and 15 gliosarcomas. GFAP was found variably positive in the glial areas. F VIII/RAg characterizes the endothelial cells and in gliosarcomas suggests the origin of the sarcomatous component from the endothelial proliferations. Laminin separates the two components and characterizes the inner and the outer basement membranes in the vessels. It is multiplied and thickened in endothelial proliferations, while it is often fragmented in the larger vessel wall proliferations. Our observations confirm that gliosarcoma represents the last stage of a process which starts with the endothelial hyperplasia of glioblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697192
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  • 3
    Electronic Resource
    Electronic Resource
    The distribution of laminin in human brain tumors: An immunohistochemical study (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 51-57 
    Details
    ISSN: 1432-0533
    Keywords: Laminin ; Brain tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunohistochemical distribution of laminin in 70 cases of primary and secondary brain tumors has been studied. The sections were fixed in Carnoy, embedded in paraffin, and treated with collagenase before applying the specific immune serum. In normal neural tissue and in gliomas, the distribution of laminin overlaps with that of basement membrane, as is known from observations on ultrastructure in the literature. The overlapping was observed also in neurinomas, papillomas of the choroid plexus, ependymomas, and meningiomas. Problems arise in the interpretation of the results in the other oncotypes. In hemangiopericytomas and hemangioblastomas, laminin demonstrates a basement membrane around the vessels only; it is absent around stromal cells. In desmoplastic medulloblastomas, laminin forms a network among the tumor celis. In primary lymphomas, concentric rings of laminin are evidenced around some vessels. In discussing the results, the ultrastructural distribution of basement membranes is taken into account.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688123
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  • 4
    Electronic Resource
    Electronic Resource
    Motor neuron disease with pallido-luysio-nigral atrophy (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 105-108 
    Details
    ISSN: 1432-0533
    Keywords: Pallido-luysio-nigral atrophy ; Motor neuron disease ; Ubiquitin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of motor neuron disease (MND) with pallido-luysio-nigral atrophy (PLNA) is reported. The 45-year-old male patient presented with lower motor neuron symptoms and signs of basal ganglia disturbance. He died after a progressive course of 7 months. Neuropathological examination revealed motor neuron loss at all spinal cord levels with sparing of Onuf's nucleus. Nerve cell loss and gliosis were also present in substantia nigra, globus pallidus, and subthalamic nucleus. The presence of ubiquitin-positive inclusions, a hallmark of most variants of MND, confirms this case as an example of MND. At immunoelectron microscopy the granules were distributed on filamentous material. The combination of clinically apparent PLNA with MND has only been described twice previously. The relationship of this syndrome to other forms of MND and its nosological placement are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454908
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of vimentin in human cerebral tumors (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 209-219 
    Details
    ISSN: 1432-0533
    Keywords: Vimentin ; Cerebral tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of vimentin (VIM) has been histochemically investigated in 53 cerebral tumors and compared in gliomas to that of glial fibrillary acidic protein (GFAP). In gliomas VIM is less positive than GFAP, but shows the same distribution. It cannot be considered as indicating immaturity of glial tumor cells. VIM is also positive in glial processes of cerebellar pilocytic astrocytomas, in Schwann cells of neurinomas and in endothelial cells of all oncotypes. In medulloblastomas, VIM decorates reactive glia cells. A diffuse positive reaction has been observed in meningiomas. In hemangioblastomas, besides intervascular and endothelial cells, groups of polygonal cells are intensely positive for both VIM and GFAP. The interpretatiên of VIM in cerebral tumors is largely based on the distribution patterns of this intermediate filament in the developing CNS of rodents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686074
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  • 6
    Electronic Resource
    Electronic Resource
    Immunohistochemical observations on rat radial glia: relationship with the origin of ethylnitrosourea-induced tumors (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 387-393 
    Details
    ISSN: 1432-0533
    Keywords: Radial glia ; Ethylnitrosourea ; Glial fibrillary acidic protein ; Vimentin ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gliomas induced in the rat by transplacental administration of ethylnitrosourea (ENU) are intensely immunoreactive for vimentin and scarcely for glial fibrillary acidic protein (GFAP). Since tumoral transformation takes place during the late fetal and early postnatal period, the sequential expression of the two glial antigens has been investigated in this age period in ENU-treated and control rats. Immunohistochemical and immunoelectron microscopical methods have been employed. Vimentin was widely expressed starting from embryonal day 14 (E 14) in the processes of radial glia; as long as radial glia was present, vimentin decorated it. GFAP was, at earliest, observed at E 20 and expressed by glial cells with a stellate, i.e., mature shape. No GFAP-positive radial process was observed. No difference was found between ENU-treated and control rats. Since ENU is most effective in producing tumors when administered at the 16–17th day of fetal life, vimentin-positive radial glia is a candidate target of ENU. The similarity of intermediate filament pattern between radial glia in the late fetal life and tumors induced by transplacental ENU suggests that radial glia might be the cell of origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227665
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  • 7
    Electronic Resource
    Electronic Resource
    The vascular response to tumor infiltration in malignant gliomas (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 369-378 
    Details
    ISSN: 1432-0533
    Keywords: Angiogenesis ; Gliomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neo-vascularization and endothelial hyperplasia have been shown to be very active in malignant gliomas. In this contribution the vascularization of the cortex infiltrated by malignant gliomas is morphometrically studied and the endothelial proliferations are immunohistochemically investigated and reconstructed by a three-dimensional computer-assisted procedure. Vessel density increases after tumor infiltration in some cases only. The diameter of vessels increases and so does the number of nuclei/vessel after the complete invasion of the cortex when vascular glomeruli develop. In completely infiltrated cortex with development of glomeruli and circumscribed necroses, vessel density is very low. No neoformation of vessels takes place before the complete infiltration of the cortex by the tumor. The hyperplastic formations, usually arranged parallel to the deep or outer cortical layers, take origin from the radially penetrating vessels from the meninges and their lateral branching. The hyperplasia deforms the vascular network, making it often inadequate to supply tumor cells. Immunohistochemically, the cells composing the hyperplastic structures are variably positive for factor VIII/RAg and, at a lesser extent, for α-smooth muscle actin. The poorness of the vascular network in many instances of completely infiltrated cortex is responsible for the development of circumscribed necroses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687371
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  • 8
    Electronic Resource
    Electronic Resource
    In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 141 (1986), S. 782-789 
    Details
    ISSN: 0006-291X
    Keywords: [abr] AD; Alzheimer's Disease ; [abr] APC; amyloid plaque core ; [abr] CVA; cerebrovascular amyloid ; [abr] MAP; microtubule-associated proteins ; [abr] NFT; neurofibrillary tangles ; [abr] PHF; paired helical filaments ; [abr] SP17; synthetic peptide (17 residues positions 12-28) ; [abr] SP28; synthetic peptide (28 residues)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(86)80241-8
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 141 (1986), S. 782-789 
    Details
    ISSN: 0006-291X
    Keywords: [abr] AD; Alzheimer's Disease ; [abr] APC; amyloid plaque core ; [abr] CVA; cerebrovascular amyloid ; [abr] MAP; microtubule-associated proteins ; [abr] NFT; neurofibrillary tangles ; [abr] PHF; paired helical filaments ; [abr] SP17; synthetic peptide (17 residues positions 12-28) ; [abr] SP28; synthetic peptide (28 residues)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(86)80241-8
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease (1997)
    Springer
    Neurogenetics 1 (1997), S. 81-87 
    Details
    ISSN: 1364-6753
    Keywords: Keywords: apoptosis, cell death, dystrophinopathy, ICE-like proteases, in situ end-labeling, muscle, tissue transglutaminase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Recent data suggest that death of muscle cells during development and in selected pathological conditions occurs via apoptosis. We investigated the occurrence of apoptosis in normal and pathological human skeletal muscle, using in situ end-labeling (ISEL) to detect DAN fragmentation, and immunohistochemistry for the expression of tissue transglutaminase and interleukin-1β-converting enzyme (ICE)-like proteases. In normal subjects, apoptotic myonuclei were occasionally observed as evidence of normal tissue turnover. Myonuclear apoptosis due to a deficit of trophic support from nerve cells also occurred in spinal muscular atrophies. No apoptosis of muscle cells was found in dystrophinopathies, myotonic dystrophy and inflammatory myopathies, suggesting that death of myofibers in those conditions is not due to activation of a gene-directed program of death. In dystrophinopathies and inflammatory myopathies, apoptosis was found in interstitial mononuclear cells, as a likely mechanism of clearance of the inflammatory infiltrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100480050012
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