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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent experimental and clinical studies suggest that tumour-induced angiogenesis may be an important step in the evolution of malignant tumours, and may be related to prognosis. In our study we examined 42 cases of breast carcinoma (mean age: 56.76 ± 13.5), 21 with lymph node metastases and 21 without. Angiogenesis was evaluated after immunohistochemical staining of tumour vessels, using polyclonal antibody to factor VIII related antigen (VIIIR-Ag) and counting of the three most active areas of neovascularization. In the same manner we counted the microvessels in lymph node metastases. The mean vessel count of node-negative cases (51.16 ± 19.32) did not differ significantly from node-positive cases (45.66 ± 17.44). In contrast patients younger than 50 years had much higher mean vessel counts (54.04 ± 16.47) than did patients older than 70 years (38.03 ± 16.73) producing a P value of ≤0.05. No association was found between tumour size and mean vessel count, nor was there any significant difference between grade I (45.94 ± 16.54), grade II (53.13 ± 23.22) and grade III tumours (51.71 ± 20.64). When we compared the mean vessel count of primary tumours with those of node metastases, we found much lower counts in the latter (P≤0.01). The differences in our results from previous studies, probably reflect the heterogeneity which exists between different tumours in their ability to induce angiogenesis. Additionally, there is some evidence in our study that angiogenesis is possibly related to patient age and probably depends on differences in the tumour stroma.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 11 (1996), S. 505-506 
    ISSN: 1437-9813
    Keywords: Inguinoscrotal lesion ; Hematoma ; Hematocele ; Neonatal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neonatal inguinoscrotal lesion, or hematocele of neonates, is attributed to trauma from the plastic clamp used to ligate the umbilical cord immediately after delivery. The pathogenesis is thought to be related to two factors: incorrect clamping technique, in which the clamp is eccentric or too distal, and the infant's position, lying over the clamp. This is a rare event that usually appears on the 2nd day of life, with very few reports recorded in the literature. The lesion does not have any complications, but may be easily confused with testicular torsion. We present two cases and review the literature.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 10 (1995), S. 241-242 
    ISSN: 1437-9813
    Keywords: Appendix testis ; Hydatid of morgagni ; Appendix epididymis ; Cryptorchidism ; Inguinal hernia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Testicular appendages represent remnants of embryonic structures. The more important are appendix testis (AT) and appendix epididymis (AE). We searched for the presence of an AT or AE in 103 consecutive inguinal hernia and 39 cryptorchidism operations performed at our department during the last 2 years and found 114 ATs (80.28%) and 52 AEs (36.31%). In 24 cases (16.9%) we found both appendages. The ages of our patients ranged from 2 months to 14 years. The diameter of the appendages was 0.3–1.7 cm. Histologically, ATs and AEs consisted of relatively vascular fibrous connective tissue. The surface epithelium was cuboidal in 77 cases, flat in 27, stratified-ciliated in 21, and cuboidal-ciliated in 19. ATs and AEs are penduculated structures and consequently subject to torsion, which is the commonest cause of testicular swelling in childhood and is accompanied by severe pain. To avoid this possibility, we suggest excision of these appendages in every operation for inguinal hernia and cryptorchidism.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-9813
    Keywords: Key words Cryptorchidism ; Epididymis ; Vas deferens ; Testis ; Histological changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cryptorchid testes are frequently accompanied by gross morphologic changes with regard to the size and shape of the testis, various degrees of detachment between the epididymis and testis, elongation of the caudal epididymis and vas deferens, as well as histologic changes. This study examined the gross and microscopic testicular, epididymal, and vas changes in relation to various parameters in 824 patients operated upon in our clinic during the last decade. The major findings were the following: (1) most patients (78.8%) were older than 4 years, and many older than 8 years (39.8%); (2) the frequency of abdominal undescended testes decreased with increasing age (P 〈0.1), while the frequency of suprascrotal testes increased with increasing age (P 〈0.001); (3) most of the undescended testes in a suprascrotal position were normal or had mild atrophy (78.7%), while those in intracanalicular, internal ring, and abdominal positions frequently presented moderate or severe atrophy (71,38%; (P 〈0.0001); and (4) most suprascrotal testes were either normal or had mild extension and looping of the epididymis (63.8%), while most of the intracanalicular, internal ring, and abdominal testes showed moderate or profound epididymal anomalies (63.4%; P 〈0.0001). We conclude that even though the necessity for early surgical correction of cryptorchidism is well established, these patients at least in our region, still tend to come very late to surgery, with consequent increased risks of infertility and malignant transformation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1437-9813
    Keywords: Cryptorchidism ; Epididymis ; Vas deferens ; Testis ; Histological changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cryptorchid testes are frequently accompanied by gross morphologic changes with regard to the size and shape of the testis, various degrees of detachment between the epididymis and testis, elongation of the caudal epididymis and vas deferens, as well as histologic changes. This study examined the gross and microscopic testicular, epididymal, and vas changes in relation to various parameters in 824 patients operated upon in our clinic during the last decade. The major findings were the following: (1) most patients (78.8%) were older than 4 years, and many older than 8 years (39.8%); (2) the frequency of abdominal undescended testes decreased with increasing age (P 〈0.1), while the frequency of suprascrotal testes increased with increasing age (P 〈0.001); (3) most of the undescended testes in a suprascrotal position were normal or had mild atrophy (78.7%), while those in intracanalicular, internal ring, and abdominal positions frequently presented moderate or severe atrophy (71,38%; (P 〈0.0001); and (4) most suprascrotal testes were either normal or had mild extension and looping of the epididymis (63.8%), while most of the intracanalicular, internal ring, and abdominal testes showed moderate or profound epididymal anomalies (63.4%;P 〈0.0001). We conclude that even though the necessity for early surgical correction of cryptorchidism is well established, these patients at least in our region, still tend to come very late to surgery, with consequent increased risks of infertility and malignant transformation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1437-9813
    Keywords: Key words Paratubal cyst ; Morgagni cyst ; Acute appendicitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paratubal cysts represent remnants of the paramesonephric or mesonephric duct, the former being more common. Most of them are asymptomatic, but they may rarely give rise to clinical problems due to enlargement or torsion. In this study, we looked for paratubal cysts or other pathological lesions of the right uterine adnexa in young females operated upon for right lower quadrant (RLQ) abdominal pain. Our material consisted of 338 white female patients aged 4–14 years. Laparotomy revealed only acute appendicitis in 283 cases, while 44 had acute appendicitis plus a coincidental paratubal cyst. Most of these cysts were smaller than 1 cm in diameter. However, 2 additional cases had torsion of a large paratubal cyst, while 5 had a ruptured corpus luteum. We suggest that a thorough search of the right adnexa for the presence of paratubal cysts during laparotomies performed for RLQ pain is a useful procedure. This approach also allows detection of other pathological lesions of the right adnexa that often produce symptoms similar to acute appendicitis.
    Type of Medium: Electronic Resource
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