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  • 1
    Electronic Resource
    Electronic Resource
    p27 expression and gastric carcinoma (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 593-593 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor — A cyclin-dependent kinase inhibitor, p27rapl, regulates progression from Gl into S phase. We read with great interest that the decrease or absence of p27 protein expression is a powerful negative prognostic marker in patients with breast1 and colorectal carcinomas2 and is a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0697-593
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  • 2
    Electronic Resource
    Electronic Resource
    Complete response of transverse colon carcinoma to S1, a new chemotherapy agent: Report of a case (1995)
    Springer
    Surgery today 25 (1995), S. 741-744 
    Details
    ISSN: 1436-2813
    Keywords: S1 ; transverse colon carcinoma ; carcinoembryonic antigen ; mucin pool ; complete response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A complete response to a new chemotherapeutic agent, S1, was achieved in a 64-year-old Japanese man with advanced transverse colon cancer. S1 is a combination of the agents tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid. Because the patient was considered to be a high operative risk due to his poor general condition, S1 was administered at 100 mg/day for 5 days/week over 12 weeks. However, as the serum carcinoembryonic antigen level continued to gradually increase, partial resection of the transverse colon was finally performed. Histopathological study of the resected specimen showed mucin pools in the colon wall with no residual viable cancer cells. No perioperative complications were recognized and the patient is now leading a normal life 6 months after his operation without any signs of recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311492
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  • 3
    Electronic Resource
    Electronic Resource
    A new approach for acute embolus occlusion of the superior mesenteric artery (1996)
    Springer
    Surgery today 26 (1996), S. 949-951 
    Details
    ISSN: 1436-2813
    Keywords: superior mesenteric artery ; acute embolus occlusion ; Fogarty balloon catheter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute embolus occlusion of the superior mesenteric artery (SMA) either demonstrates a poor prognosis, or forces the patients to endure miserable postoperative dietary lives. Recently, we developed a new successful technique which reduced the length of the intestinal segment that had to be removed. The technique was as follows: (1) the distal end of the SMA was ligated to avoid perfusion of the necrotic segment, and (2) a Fogarty balloon catheter was inserted from the distal end of the SMA and then passed proximally to remove any remaining clots. Using the above-described technique on 3 cases from 1992 to 1994, we were thus able to shorten the length of the intestine that had to be removed and thereby greatly improve the patients' postoperative dietary lives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311804
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of ornithine decarboxylase messenger ribonucleic acid expression in colorectal carcinoma (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 1095-1100 
    Details
    ISSN: 1530-0358
    Keywords: Ornithine decarboxylase ; c-myc ; Proto-oncogene ; Reverse transcriptase-polymerase chain reaction ; Colorectal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Ornithine decarboxylase (ODC) is a rate-limiting enzyme for polyamine synthesis. An elevated protein level of ODC was observed in the tumors. There has been, however, little information reported so far on the expression of ODC messenger ribonucleic acid (mRNA) in clinical colorectal carcinomas.In vitro studies disclosed that the transcriptions of the ODC gene is regulated by the c-myc gene. METHODS: The expression of ODC and c-myc mRNA in biopsy specimens obtained from both tumor tissue and the corresponding normal tissue was examined by the reverse transcriptase polymerase chain reaction method in 40 cases of colorectal carcinoma. RESULTS: The expression of ODC mRNA was observed in both tumor tissue and normal tissue. The tumor to normal ratio of ODC mRNA was higher in cases with deeply invasive tumors than in cases with shallow tumors, and it was also higher in Dukes B or C cases than in Dukes A cases. There was a significant correlation between the tumor to normal ratio of c-myc mRNA and that of ODC mRNA in each case. CONCLUSIONS: These findings suggested that 1) the study of the expression of ODC mRNA may be useful for preoperatively predicting more advanced disease of colon carcinoma, and 2) there was a significant correlation between expression of ODC and c-myc mRNA in the clinical samples, which was similar to the findings of a previous in vitro study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050936
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of the Genetic Alterations in a Case of Juvenile Multiple Colon Carcinoma With Hypogammaglobulinemia (2000)
    Springer
    Annals of surgical oncology 7 (2000), S. 692-695 
    Details
    ISSN: 1534-4681
    Keywords: Hypogammaglobulinemia ; Multiple colon cancer ; P53 ; K-ras ; Replication error
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We have previously reported the clinical characterization of a case of juvenile multiple colorectal carcinoma with hypogammaglobulinemia. Several recent studies have determined that agammaglobulinemia was caused by the loss of Bruton’s tyrosine kinase (Btk) function. However, any genetic alterations associated with carcinoma formation in individuals with this immunodeficient disease have not been reported. Methods: DNA from eight carcinoma tissues and nine adenoma tissues from this reported case were examined for mutations in p53 by single strand conformation polymorphism analysis, K-ras by mutant allele specific analysis, and replication error or loss of heterozygosity of the TP53 locus on chromosome #17. Results: We found that p53 and K-ras were mutated in the carcinoma tissues. However, each tumor showed unequal and diverse results. Conclusions: The progression of individual tumor was not due to a common genetic event caused directly under the influence of the primary disease at the genetic level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-000-0692-7
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