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  • 1
    Electronic Resource
    Electronic Resource
    Serial changes in motor and somatosensory evoked potentials in putaminal haemorrhage (1996)
    Springer
    Journal of neurology 243 (1996), S. 73-78 
    Details
    ISSN: 1432-1459
    Keywords: Somatosensory evoked potentials ; Motor evoked potentials ; Putaminal haemorrhage ; Stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Little is known about evoked potential changes in putaminal haemorrhage. In this study, somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) have been serially evaluated and their role in the prognosis of putaminal haemorrhage is now reported. Nineteen patients with CT- or MRI-proven putaminal haemorrhage were examined after a mean duration of 13 days (range 2–30); there were 4 females and 9 males, ranging in age between 25 and 70 years. The haematomas were of medium size in 13 and large or small in 3 patients each. The changes in the clinical picture and the SEPs and MEPs were evaluated on admission, and after 30 and 90 days. Central motor conduction time (CMCT) could not be recorded in 13, but was prolonged in 2 and normal in 4 patients. Median SEPs revealed the absence of near field potentials in 11 and prolongation of N9–N20 conduction time in 1 patient. In the follow-up period MEP and SEP abnormalities only changed in 5 patients; MEPs changed in 4 and SEPs in 2. The period of normalisation of MEPs ranged between 1 and 6 months. CMCT correlated with motor and N9–N20 conduction time with sensory impairment. Eight patients had poor, 6 partial and 5 complete recovery. Power, sensation, CMCT, and size and location of haematoma made positive contributions to recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00878535
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  • 2
    Electronic Resource
    Electronic Resource
    Central motor conduction studies in internal capsule and corona radiata infarction (1997)
    Springer
    Journal of neurology 244 (1997), S. 579-585 
    Details
    ISSN: 1432-1459
    Keywords: Key words Motor evoked potential ; Stroke ; Infarction ; Corona radiata ; Internal capsule ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical and evoked-potential studies in internal capsule and corona radiata infarction are lacking. We report the results of a clinical and central motor conduction time (CMCT) study in 16 patients with internal capsule and 17 with computed tomography (CT)-proven corona radiata infarction. Patient’s outcome was defined at the end of 3 months on the basis of the Barthel Index score. Four patients with type A capsular infarction (middle third of posterior limb of internal capsule) all had severe weakness, while 2 also had persistently unrecordable CMCT and poor outcome. Twelve patients with type B internal capsular infarction (genu, anterior limb, anterior or posterior third of posterior limb) had a milder degree of weakness, and CMCT was recordable in 9. At 3 months’ follow-up, however, CMCT was recordable in all 12 patients. All of these patients had a partial (n = 4) or complete (n = 5) recovery. Thirteen patients with type A corona radiata infarction (middle third of corona radiata) had more pronounced weakness, and CMCT was unrecordable in all of these patients except 1 on initial examination. Follow-up after 3 months was possible in 8 patients, and CMCT became recordable in 3. One of these patients had complete, 3 partial, and 4 poor recovery. In type B corona radiata infarction (anterior or posterior third of corona radiata), the clinical signs and CMCT did not follow a regular pattern. Clinical and CMCT abnormalities in internal capsular infarction followed a more predictable pattern compared with those in corona radiata infarction. A less predictable pattern of weakness and CMCT change in corona radiata infarction may be attributed to a less definite organisation of motor pathways compared with the internal capsule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050147
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  • 3
    Electronic Resource
    Electronic Resource
    Placental transfer of metals of coal fly ash into various fetal organs of rat (1990)
    Springer
    Archives of toxicology 64 (1990), S. 153-156 
    Details
    ISSN: 1432-0738
    Keywords: Fly ash ; Metals ; Distribution ; Organs ; Rat ; Fetus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fly ash (100 mg/kg body weight) was administered intratracheally to 14-day pregnant rats for 6 consecutive days. On day 20 of gestation the translocation of metals present in the fly ash to various maternal and fetal organs was studied. Fly ash administration to pregnant mothers retarded the growth of fetal heart and kidney as determined by their weights. Fly ash instillation increased organ levels of nearly all the metals studied in both mother and fetus. Most of the metals present in coal fly ash were transferred in significant amounts through placenta to several fetal organs. However, the pattern of their distribution into various fetal organs was different for different metals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974402
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  • 4
    Electronic Resource
    Electronic Resource
    A study of nerve conduction velocity, late responses and neuromuscular synapse functions in organophosphate workers in India (1988)
    Springer
    Archives of toxicology 61 (1988), S. 496-500 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate ; Occupational exposure ; Neurotoxicity ; Nerve conduction ; Neuromuscular synapse function ; Late responses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the effect of occupational organophosphate exposure on neuromuscular function, 24 workers exposed to fenthion [0,0-dimethyl-0(4-methyl mercapto-3 methyl phenyl phosphorothioate], whose mean age was 31.7 years (range 22–50) and mean duration of exposure to fenthion 8.5 years (range 1–19) were subjected to detailed clinical and neurophysiological evaluation after spraying. The neurophysiological tests included motor and sensory nerve conduction velocity; F response, H reflex and electromyographic neuromuscular synapse testing. Fenthion exposure was monitored by serum acetyl cholinesterase (AchE) levels. The observations were repeated after withdrawing the workers from fenthion exposure for 3 weeks to study the reversibility of the observed changes. There was no clinical evidence of peripheral neuropathy or muscle weakness. However, peroneal motor conduction velocity (p〈0.05) terminal motor latency of median (p〈0.1), and peroneal nerve (p〈0.05); F minimal latency and H reflex latency (p〈0.01) were significantly affected. Twenty-nine per cent of workers had repetitive muscle activity. Serum AchE levels also showed significant changes (p〈0.01). The clinical significance of these subtle neurophysiological changes requires further investigation and follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293697
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  • 5
    Electronic Resource
    Electronic Resource
    Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash (1986)
    Springer
    Archives of toxicology 58 (1986), S. 199-202 
    Details
    ISSN: 1432-0738
    Keywords: Coal fly ash ; Microsome ; Phosphatidylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of intratracheal administration of fly ash (50 mg/kg body weight, daily for 7 days) on hepatic microsomal phospholipid metabolism has been studied in rats using various phospholipid precursors, viz NaH2 32PO4, (methyl-14C)-choline, and (methyl-14C)-methionine. Fly ash administration significantly increased microsomal phosphatidylcholine (PC), and lysophosphatidylcholine (LPC). The incorporation of NaH2 32PO4 into total liver phospholipids, PC and Phosphatidyl ethanolamine (PE) was significantly increased in fly ash-treated rats as compared to the control. Fly ash administration also increased the incorporation of (methyl-14C)-choline into microsomal PC. Incorporation of (methyl-14C)-methionine into microsomal PC was not affected. Fly ash administration decreased the per cent distribution of arachidonic acid in PC and PE and increased that of oleic acid in PC and of linoleic acid in PE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340982
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  • 6
    Electronic Resource
    Electronic Resource
    Lipid Metabolism in Hypervitaminosis A (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 910-911 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male Wistar albino rats weighing 145150 g were divided into two groups of six each and were kept on stock diet and water ad libitum. To one group 105 i.u. of retinol (Prepalin, Glaxo Ltd., India) were given intramuscularly daily for ten days. Rats without retinol were the control. A daily record of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209910a0
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Dihydrostreptomycin on Tissue Lipid of Guinea-pigs (1965)
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 869-870 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Female guinea-pigs in groups of four, weighing 350-380 g, were intramuscularly given saline solution of dihydrostreptomycin sulphate (Pfizer) (0-1 g/kg body weight). Guinea-pigs without dihydrostreptomycin served as the controls. After ten days of administration of the drug a saline solution of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/207869a0
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of neonatal monosodium glutamate on the activities of glutamate dehydrogenase and aminotransferases in the circumventricular organs of rat brain (1995)
    Springer
    Amino acids 8 (1995), S. 393-395 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Monosodium glutamate ; Glutamate dehydrogenase ; Aminotransferases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glutamate (Glu) the major amino acid in mammalian brain and most dietary proteins possesses neurotransmitter as well as neurotoxic properties. We administered monosodium glutamate (MSG) 4 mg/g bwt, sc on postnatal day (PND) 1 through 10 to rats on alternate days or daily and sacrificed them on PND 45 or PND 90 respectively. The activities of glutamate dehydrogenase and aminotransferases were evaluated in the circumventricular organs of brain. Results show that neonatal MSG produces alterations in glutamate metabolism in blood-brain-barrier deficient regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806557
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  • 9
    Electronic Resource
    Electronic Resource
    Cytotoxicity of intratracheally administered coal fly ash: Studies on lipids in the lung of rats (1985)
    Springer
    Archives of environmental contamination and toxicology 14 (1985), S. 95-103 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The effect of intratracheal administration of coal fly ash daily for seven consecutive days was studied on the lung lipids of rats for periods of 7, 15, 30, 60, 90 and 120 days. A significant increase in lung weight was noted on 7, 30, and 90 days after treatment. Seven days after administration, a significant increase was observed in lung total lipids, total, free and esterified cholesterol, triglycerides, free fatty acids, and total phospholipids. Phosphatidyl choline contents of the lung showed a significant increase 15 and 60 days after treatment. Fly ash significantly increased total phospholipids, phosphatidyl choline, and proteins of lung lavage. The incorporation of32P into total phospholipids and phosphatidyl choline of lung and lung lavage was increased in the treated rats. Fly ash profoundly decreased total unsaturation of fatty acids in both phosphatidyl choline and phosphatidyl ethanolamine. Lipid peroxidation of lung lipids and the peroxidative capacity was greater in benzene-extracted fly ash residue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055767
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  • 10
    Electronic Resource
    Electronic Resource
    Cytotoxicity of intratracheally administered coal fly ash: Studies on liver and plasma lipids in rats (1985)
    Springer
    Archives of environmental contamination and toxicology 14 (1985), S. 105-110 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The effect of intratracheal administration of coal fly ash has been studied on liver and plasma lipids of rats. Liver total cholesterol, esterified and free cholesterol, triglycerides, free fatty acids, and phospholipid levels were altered at different periods of time after treatment. Fly ash administration significantly reduced plasma total cholesterol levels up to 30 days after treatment and these were reflected both in its free and esterified cholesterol components. Plasma total phospholipids were reduced up to 60 days after fly ash treatment, but phosphatidyl choline content showed reductions up to 30 days after treatment. Plasma lysophosphatidyl choline was reduced 60 days after treatment. Fly ash administration caused peroxidation of liver lipids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055768
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