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  • 1
    Electronic Resource
    Electronic Resource
    Studies on transfer ribonucleic acids and related compounds. 22. Joining of 3'-modified oligonucleotides by T4 RNA ligase. Synthesis of a heptadecanucleotide corresponding to the bases 61-77 from Escherichia coli tRNA fMet (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 4894-4899 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00616a006
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  • 2
    Electronic Resource
    Electronic Resource
    The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis (1992)
    Springer
    Anatomy and embryology 186 (1992), S. 107-124 
    Details
    ISSN: 1432-0568
    Keywords: Condensations ; Osteogenesis ; Chondrogenesis ; Mutants ; Morphology ; Membranous skeleton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Elements of the vertebrate skeleton are initiated as cell condensations, collectively termed the ‘membranous skeleton’ whether cartilages or bones by Grüneberg (1963). Condensations, which were identified as the basic cellular units in a recent model of morphological change in development and evolution (Atchley and Hall 1991) are reviewed in this paper. Condensations are initiated either by increased mitotic activity or by aggregation of cells towards a centre. Prechondrogenic (limb bud) and preosteogenic (scierai ossicle) condensations are discussed and contrasted. Both types of skeletogenic condensations arise following epithelial-mesenchymal interactions; condensations are identified as the first cellular product of such tissue interactions. Molecular characteristics of condensations are discussed, including peanut agglutinin lectin, which is used to visualize prechondrogenic condensations, and hyaluronan, hyaladherins, heparan sulphate proteoglycan, chondroitin sulphate proteoglycan, versican, tenascin, syndecan, N-CAM, alkaline phosphatase, retinoic acid and homeobox-containing genes. The importance for the initiation of chondrogenesis or osteogenesis of upper and lower limits to condensation size and the numbers of cells in a condensation are discussed, as illustrated by in vitro studies and by mutant embryos, including Talpid3 in the chick and Brachypod, Congenital hydrocephalus and Phocomelia in the mouse. Evidence that genes specific to the skeletal type are selectively activated at condensation is discussed, as is a recent model involving TGF-β and fibronectin in condensation formation. Condensations emerge as a pivotal stage in initiation of the vertebrate skeleton in embryonic development and in the modification of skeletal morphology during evolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174948
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  • 3
    Electronic Resource
    Electronic Resource
    Ectopic ossicles associated with metacercariae of Apophallus brevis (Trematoda) in yellow perch, Perca ftavescens (Teleostei): development and identification of hone and chondroid bone (1994)
    Springer
    Anatomy and embryology 190 (1994), S. 29-46 
    Details
    ISSN: 1432-0568
    Keywords: Ectopic ossification ; Ossicles ; parasite infection ; Chondroid bone ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper describes the development and tissues in mineralized ossicles in the musculature of Perca flavescens infected with metacercariae of the trematode Apophallus brevis. Analysis involved light microscopy, transmission and scanning electron microscopy, X-ray scanning electron microprobe analysis, and tetracycline labelling. Two to 14 days post-infection, fibroblast-like host cells stream towards the parasite cyst forming a fusiform cellular capsule. By 14 days post-infection the capsule differentiates into an inner hypertrophied layer, an extensive middle layer of fibroblast-like cells, and a thin outer layer of flattened fibroblast-like cells forming a fibrous sheath at the capsule/muscle interface. From 21–35 days post-infection, a bony tissue is deposited periosteally in an equatorial ring around the cyst. With time, additional tissue is secreted over the ring increasing its thickness and advancing the matrix front towards the poles of the ossicle. Plump osteoblast-like cells cover the developing ossicle and may become trapped within the matrix in lacunae encapsulated by collagen. By 63 days post-infection, medium-sized ossicles are morphologically similar to large cysts from perch captured in the wild; ovoid with two polarized canals, but lacking acellular or lamellar bone-like tissue. Mineralized ossicles contain calcium, phosphorus and oxygen. Large ossicles retrieved from perch given multiple doses of tetracycline revealed discrete fluorescent bands, indicative of incremental growth. Fully developed ossicles are composed of two skeletal tissues, an inner region of chondroid bone and an outer region of acellular, lamellar bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185844
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  • 4
    Electronic Resource
    Electronic Resource
    A quantitative analysis of human astrocytosis (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 535-537 
    Details
    ISSN: 1432-0533
    Keywords: Astrocytosis ; Hyperplasia ; Quantitative analysis ; Immunohistochemistry ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The number of astrocytes in an atrophic human brain was counted with the aid of immunohistochemistry for glial fibrillary acidic protein. Microscopically, astrocytosis was remarkable in the cerebral neocortex and white matter. Taking the cortical atrophy into consideration, however, the total number of astrocytes in the cortical layers II – VI was not increased. The number of astrocytes in the white matter was not increased either. It is indicated that astrocytosis does not always mean hyperplasia (net increase of total number) of astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687144
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies of blood monocytes infiltrating into the neonatal rat brain (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 291-297 
    Details
    ISSN: 1432-0533
    Keywords: Blood monocyte ; Immunofluorescence study ; Neonatal brain ; Ameboid microglia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brains of normal rats ranging in age from newborn to adult were observed with immunofluorescence technique using anti-granulomonocyte antiserum. For the first 10 days after birth, many cells with positive fluorescence were found in the white matter, the subependyma, the extra-parenchymal spaces, and the leptomeninx, but very few in the gray matter. They were mononuclear, rich in cytoplasm, and globular or irregular in shape. After about day 10 p.n., the positive cells decreased in number and became slender. However, there was no change in the distribution pattern. After about 3 weeks of age, no positive cells were detected in the brain parenchyma, except for very rare necrobiotic ones. It was suggested that blood monocytes infiltrate into the brain parenchyma of normal neonatal rat, but only for a while in the limited areas (white matter and subependyma). They have the morphology and distribution of the “ameboid microglia” of neonatal brain. These monocytes disappear from the brain finally by the end of month 1 p.n.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687611
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of temperature on morphological landmarks critical to growth and survival in larval Atlantic cod (Gadus morhua) (1996)
    Springer
    Marine biology 124 (1996), S. 593-606 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The morphology and function of structures important to energy acquisition were studied from spawning to the stage of transformation of larva to pelagic juvenile in Atlantic cod, Gadus morhua L., from December 1991 to July 1992. Fertilized eggs produced by adult fish from two genetically discrete populations (Newfoundland and Scotian Shelf) were raised under similar conditions in the laboratory at temperatures of 5 and 10°C. Subsamples of larvae were removed from cultures daily for 10 d, and then less frequently, and fixed for light microscopy and scanning electron microscopy. Nine functional morphological “landmarks” important to feeding, respiration and locomotion were chosen from observation of 280 ind. These landmarks defined 12 major developmental stages, from hatching to the pelagic juvenile stage. One of the feeding landmarks, intestinal stage, varied as a function of age and size and the variance in development was higher at 10°C than at 5°C; Newfoundland larvae developed more complex intestines than did Scotian Shelf larvae. In addition, Newfoundland larvae had significantly higher growth rates than those of Scotian Shelf larvae. Despite the higher growth rates and greater structural complexity of the intestine in Newfoundland larvae, the rate of yolk utilization was not significantly different between Newfoundland and Scotian Shelf larvae. Staging of respiratory landmarks showed that the gill arches were probably used preferentially in feeding while respiration was cutaneous. The gills, operculum and gill rakers developed late in larval life and accompanied the transition from cutaneous to branchial respiration. In the yolk-sac period, development of feeding and respiratory structures may be largely genetically controlled. During exogenous feeding, extrinsic factors also become important, as shown by the size and age-independent variation in intestinal development of larval cod raised at different temperatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351041
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Latent development of cardiac tamponade heralded by a progressive fall in hepatic venous hemoglobin oxygen saturation (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1277-1277 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709354
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  • 8
    Electronic Resource
    Electronic Resource
    Globalization, Alliances, Diversification and Innovation: A Case Study from Hitachi Ltd (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Creativity and innovation management 3 (1994), S. 0 
    Details
    ISSN: 1467-8691
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-8691.1994.tb00112.x
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  • 9
    Electronic Resource
    Electronic Resource
    Management of Corporate Innovation: A Case Study from the Nippon Steel Corporation (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Creativity and innovation management 1 (1992), S. 0 
    Details
    ISSN: 1467-8691
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Managing innovation in Japanese corporations has received considerable international attention. The case example reports the diversification of Nippon Steel Corporation, which is the largest steel manufacturing firm in the world; into electronics; information technology; biotechnology; new materials; and high-tech oriented services, using documents provided by the organization. The case reveals an important example of managing innovation in the emerging era of global technological competition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-8691.1992.tb00032.x
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  • 10
    Electronic Resource
    Electronic Resource
    Japanese LCD Industry: Competing through Knowledge Management (1999)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Creativity and innovation management 8 (1999), S. 0 
    Details
    ISSN: 1467-8691
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-8691.00123
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