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  • 1
    Electronic Resource
    Electronic Resource
    Effect of α2-adrenoceptor antagonist on platelet activation during insulin-induced hypoglycaemia in Type 2 (non-insulin-dependent) diabetes mellitus (1988)
    Springer
    Diabetologia 31 (1988), S. 657-663 
    Details
    ISSN: 1432-0428
    Keywords: Adrenergic α receptor blockers ; platelet aggregation ; β-thromboglobulin ; hypoglycaemia ; diabetes mellitus ; midaglizole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of epinephrine in platelet activation and the effect of an α2-adrenoceptor antagonist, midaglizole, during insulin-induced hypoglycaemia in Type 2 (noninsulin-dependent) diabetes mellitus were examined. The action of midaglizole as a platelet α2-antagonist was confirmed by in vitro studies using platelet-rich plasma and washed platelet suspension. Hypoglycaemia was induced by a bolus injection of short-acting insulin in 24 diabetic patients. They were divided into two groups, a control group (n=12) and an α2-group (n=12), and midaglizole was administered orally 60 min before insulin injection in the latter. Blood glucose and plasma C-peptide levels were significantly decreased (p〈0.005) by insulin injection in both groups. Counter-regulatory hormones, including epinephrine, and arginine vasopressin were similarly increased at the hypoglycaemic nadir compared with the levels at 0 min in both groups. Plasma β-thromboglobulin was increased at the hypoglycaemic nadir (165.5±12.6ng/ml) compared with the level at 0 min (121.0±11.5, p〈0.005) in the control group, whereas no significant increase was demonstrated in the α2 group. These results suggest that plasma epinephrine plays an important role in platelet activation during hypoglycaemia in Type 2 diabetes mellitus, and that the platelet activation is prevented by α2-adrenoceptor antagonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278748
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  • 2
    Electronic Resource
    Electronic Resource
    Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: Bradykinin may improve insulin resistance in dogs and humans (1994)
    Springer
    Diabetologia 37 (1994), S. 300-307 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; hypertension ; angiotensin converting enzyme inhibitor ; sulphydryl group ; insulin sensitivity ; bradykinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study compared the effect on insulin sensitivity of ACE inhibitors with a sulphydryl group (captopril) or those without a sulphydryl group (delapril and enalapril) during the hyperinsulinaemic euglycaemic clamp test in both animal and clinical experiments. A possible contribution of bradykinin to the improvement of insulin sensitivity by ACE-inhibition was also studied. In healthy control and depancreatized dog experiments, administration of captopril either intravenously (3.0 mmol · kg−1) or orally (5.0 mmol · kg−1) increased insulin sensitivity indices and plasma bradykinin concentrations. In comparison, intravenous administration of an active metabolite of delapril (3.0 mmol · kg−1) and oral administration of either delapril or enalapril (5.0 mmol · kg−1) showed slight, but not significant increases in insulin sensitivity indices and plasma bradykinin concentrations. Infusion of a bradykinin antagonist (N-α-adamantaneacetyl-d-Arg-[Hyp3, Thi5,8,d-Phe7]-bradykinin) (0.5 nmol · kg−1 · min−1) abolished the effect of captopril on insulin sensitivity. Furthermore, intravenous administration of bradykinin (0.1 nmol · kg−1 · min−1) increased insulin sensitivity indices. In clinical experiments, insulin sensitivity indices decreased in the following order: normotensive healthy subjects, hypertensive non-diabetic patients, normotensive NIDDM patients and hypertensive NIDDM patients. In these four groups, oral administration of captopril (2.0 mmol · kg−1) significantly increased insulin sensitivity indices, and a concomitant increase in plasma bradykinin concentrations was observed. By contrast, oral administration of enalapril or delapril showed slight, but not significant effects on insulin sensitivity indices and plasma bradykinin concentrations. From these studies, it is concluded that ACE inhibitors with a sulphydryl group have more potent action on the improvement in insulin sensitivity than those without a sulphydryl group. Bradykinin may also possibly be involved in the mechanism underlying the improvement in insulin sensitivity associated with ACE-inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398058
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  • 3
    Electronic Resource
    Electronic Resource
    Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: bradykinin may improve insulin resistance in dogs and humans (1994)
    Springer
    Diabetologia 37 (1994), S. 300-307 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus, hypertension, angiotensin converting enzyme inhibitor, sulphydryl group, insulin sensitivity, bradykinin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study compared the effect on insulin sensitivity of ACE inhibitors with a sulphydryl group (captopril) or those without a sulphydryl group (delapril and enalapril) during the hyperinsulinaemic euglycaemic clamp test in both animal and clinical experiments. A possible contribution of bradykinin to the improvement of insulin sensitivity by ACE-inhibition was also studied. In healthy control and depancreatized dog experiments, administration of captopril either intravenously (3.0 mmol·kg−1) or orally (5.0 mmol· kg−1) increased insulin sensitivity indices and plasma bradykinin concentrations. In comparison, intravenous administration of an active metabolite of delapril (3.0 mmol·kg−1) and oral administration of either delapril or enalapril (5.0 mmol·kg−1) showed slight, but not significant increases in insulin sensitivity indices and plasma bradykinin concentrations. Infusion of a bradykinin antagonist (N-α-adamantaneacetyl-D- Arg-[Hyp3,Thi5,8,D-Phe7]-bradykinin) (0.5 nmol·kg−1·min−1) abolished the effect of captopril on insulin sensitivity. Furthermore, intravenous administration of bradykinin (0.1 nmol·kg−1·min−1) increased insulin sensitivity indices. In clinical experiments, insulin sensitivity indices decreased in the following order: normotensive healthy subjects, hypertensive non-diabetic patients, normotensive NIDDM patients and hypertensive NIDDM patients. In these four groups, oral administration of captopril (2.0 mmol·kg−1) significantly increased insulin sensitivity indices, and a concomitant increase in plasma bradykinin concentrations was observed. By contrast, oral administration of enalapril or delapril showed slight, but not significant effects on insulin sensitivity indices and plasma bradykinin concentrations. From these studies, it is concluded that ACE inhibitors with a sulphydryl group have more potent action on the improvement in insulin sensitivity than those without a sulphydryl group. Bradykinin may also possibly be involved in the mechanism underlying the improvement in insulin sensitivity associated with ACE-inhibition. [Diabetologia (1994) 37: 300–307]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398058
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  • 4
    Electronic Resource
    Electronic Resource
    The lipoprotein lipase activator, NO-1886, suppresses fat accumulation and insulin resistance in rats fed a high-fat diet (2000)
    Springer
    Diabetologia 43 (2000), S. 875-880 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Hormone sensitive lipase, obesity, respiratory quotient, skeletal muscle, visceral fat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in rats fed a high-fat diet.¶Methods. Male, Sprague-Dawley rats were fed for 10 weeks on a chow diet or a high-fat diet with, or without, NO-1886 (50 mg · kg–1· day–1). Weight gain, fat accumulation and both hormone-sensitive and lipoprotein, lipase activities were measured. Insulin action was assessed by the euglycaemic hyperinsulinaemic clamp and metabolic rate/substrate utilisation by open-circuit respirometry.¶Results. Compared with chow-fed controls, a high-fat diet increased weight gain, an effect lessened by NO-1886 [weight gain (g): chow, 37 ± 3, high-fat, 222 ± 9; high-fat + NO-1886, 109 ± 6, all groups differed p 〈 0.001]. A similar pattern existed for fat accumulation [visceral fat (g): chow, 35.9 ± 3.2; high-fat, 81.9 ± 6.6; high-fat + NO-1886, 52.3 ± 4.7, p 〈 0.01 high-fat vs the other groups]. A high-fat diet induced whole-body insulin resistance (clamp glucose infusion rate: 4.8 ± 1.3 mg · kg–1· min–1 vs 10.6 ± 1.1 for the chow group, p 〈 0.01) with NO-1886 lessening this effect (8.3 ± 0.5, p 〈 0.05 vs high-fat). The 24-h respiratory quotient was lower in the high-fat + NO-1886 group (0.825 ± 0.010) compared with high-fat alone (0.849 ± 0.004, p 〈 0.05). A high-fat diet increased lipoprotein and hormone-sensitive, lipase activities in epididymal fat, an effect not altered by NO-1886. In myocardium and skeletal muscle a high-fat diet lowered lipoprotein lipase activity, an effect lessened by NO-1886.¶Conclusion/interpretation: Lipoprotein lipase activators could have potential benefits for the treatment of obesity by increasing fat utilisation. [Diabetologia (2000) 43: 875–880]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051464
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  • 5
    Electronic Resource
    Electronic Resource
    Prediction of the histologic type of bile duct cancer by using intraductal ultrasonography (1999)
    Springer
    Abdominal imaging 24 (1999), S. 484-490 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Intraductal ultrasonography—Bile duct cancer—Papillary adenocarcinoma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Patients with papillary adenocarcinoma survive longer than do patients with other histologic types of bile duct tumors. We evaluated the usefulness of intraductal ultrasonography (IDUS) for predicting the histology. Methods: Preoperative tumor assessment was performed by using IDUS through a percutaneous tract or the transpapillary route in 37 patients with extrahepatic bile duct cancer. In 30 of 37 patients, imaging results were compared prospectively with histologic findings in resected specimens. Probes 2.0 mm in diameter and 20 MHz in frequency were mainly used. When IDUS showed a “narrow-based polypoid pattern” or a “papillary surface pattern,” the patients were judged as having papillary adenocarcinoma. Results: The accuracy, sensitivity, and specificity of IDUS in predicting papillary adenocarcinoma were 90%, 89%, and 90%, respectively. When intraductal ultrasonography showed a papillary surface pattern or a narrow-based polypoid pattern, lymph node metastases and perineural invasion were rarely seen when compared with other patients with bile duct cancer (p 〈 0.05). Conclusion: IDUS is useful for assessing the histologic type of bile duct cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900545
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  • 6
    Electronic Resource
    Electronic Resource
    Catheter dislodgement of percutaneous transhepatic biliary drainage: identification of role of puncture sites and catheter sheath (2000)
    Springer
    Abdominal imaging 25 (2000), S. 587-591 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Percutaneous transhepatic biliary drainage—Catheter—Dislodgement—Complication.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To identify the appropriate puncture points in the bile duct to avoid catheter dislodgement. Methods: Percutaneous transhepatic biliary drainage catheters (n = 300) were placed in 242 patients. The frequency of dislodgement (complete dislodgement or bending of the catheter) was prospectively investigated. The puncture site of the bile duct was classified on the ultrasonographic findings as follows: Main-B3, main branch of the lateral inferior segment; peripheral-B3, peripheral branch of the lateral inferior segment; B2, lateral superior segment; left hepatic duct, proximal portion of the left hepatic duct; B8, anterior superior segment; B5, anterior inferior segment; B5 + 8, main bile duct of the anterior segment; B6, bile duct of posterior inferior segment; and right hepatic duct, proximal portion of the right hepatic duct. Results: When a catheter without an outer sheath was used, catheter dislodgement in peripheral-B3 (2/11, 18%) was more common than in main-B3 (0/32, 0%; p 〈 0.05). In B5, catheter dislodgement (6/12, 50%) was more frequent than in B8 (3/20, 15%; p 〈 0.05) and in B6 (0/14, 0%; p 〈 0.005). When a catheter with an outer sheath was used, catheter dislodgement (2/207, 1%) was rare. Conclusion: Drainage from B5 and peripheral-B3 is associated with a high risk of dislodgement of the catheter. A catheter with an outer sheath was useful to prevent catheter dislodgement. RID="" ID="" 〈E5〉Correspondence to:〈/E5〉 K. Tamada
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002610000047
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  • 7
    Electronic Resource
    Electronic Resource
    High energy electron disinfection of sewage wastewater in flow systems
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part C, 35 (1990), S. 440-444 
    Details
    ISSN: 1359-0197
    Keywords: Disinfection ; batch systems ; coliforms ; depth effect ; electron beam ; flow system ; flowrate effect ; wastewater
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1359-0197(90)90135-5
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  • 8
    Electronic Resource
    Electronic Resource
    Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: Direct evidence for liberation of bradykinin by rat glandular kallikreins
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 127 (1985), S. 289-295 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(85)80157-1
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  • 9
    Electronic Resource
    Electronic Resource
    Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: Direct evidence for liberation of bradykinin by rat glandular kallikreins
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 127 (1985), S. 289-295 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(85)80157-1
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  • 10
    Electronic Resource
    Electronic Resource
    β"2-Microglobulin Modified with Advanced Glycation End Products Induces Interleukin-6 from Human Macrophages: Role in the Pathogenesis of Hemodialysis-Associated Amyloidosis
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 201 (1994), S. 1235-1241 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1994.1837
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