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  • 1
    Electronic Resource
    Electronic Resource
    IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease (1999)
    Springer
    Immunogenetics 49 (1999), S. 527-531 
    Details
    ISSN: 1432-1211
    Keywords: Key words Inflammatory bowel disease ; IL1B gene polymorphism ; Crohn's disease ; Ulcerative colitis ; Disease susceptibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  There is evidence of a disbalance in the inflammatory regulation of patients with inflammatory bowel diseases (IBD). Interleukin-1β plays an important role in the pro-inflammatory response. Our aim was to study the influence which IL1B gene polymorphisms may have on the severity and course of these diseases. Ninety-six patients with ulcerative colitis (UC), 98 patients with Crohn's disease (CD), and 132 ethnically matched healthy individuals (HC) were typed for the polymorphic sites in the promoter region (position –511) and in exon 5 (position +3953) of the IL1B gene, using polymerase chain reaction (PCR)-based methods. In the CD group a significant association (P=0.009) was found in this pair of genes. Homozygotes for allele 1 at position +3953 were more often present (69% vs 31%) in the subgroup of patients carrying at least one copy of allele 2 at position –511. This association was significant in patients with non-perforating disease (P=0.002), but was not present in patients with perforating-fistulizing disease. The distribution of both allelic pairs in the non-fistulizing group proved to be significantly different from HC (P〈0.05), UC (P〈0.03), and the fistulizing group (P〈0.05). There was a similar association in non-operated patients (P=0.024), whereas no such association was found in surgically treated patients. Among carriers of allele 2 at position –511, UC patients with more severe bleeding symptoms (P=0.006) were less frequently found. These results suggest that IL1B gene polymorphisms participate in determining the course and severity of inflammatory bowel disease and contribute to explain the heterogeneity of these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050530
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  • 2
    Electronic Resource
    Electronic Resource
    Following the Artificially Induced Eel Maturation Process by Means of In Vivo CT Scanning (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the World Aquaculture Society 35 (2004), S. 0 
    Details
    ISSN: 1749-7345
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Artificially induced maturation of 10 male eels Anguilla anguilla L. weighing 170 ± 30-3 g was followed for 6 wk with in vivo CT scanning in a repeated manner. Since testis tissue has a well defined X-ray density value, the volumetric development could be described. Parallel with this process, a strong decrease of the abdominal fat volume was measured and depicted with the applied surface smoothing method. As an affect of the hCG treatment (250 IU/week per eel) at the third wk, the testis could clearly be recognized on the images. From that time the average testis volume values of the 10 eels were 4,975, 6345, 11,583 and 14,553 mmJ respectively. At the sixth wk, the relative testis volume in the abdomen was 25%. In the fillet a characteristic shift (from -10 to -20 Hounsfield units) of the density histogram towards the fat interval was detected. The average density value of the fillet was found to be zero; this was supported furthermore by the histological analysis of the fillet (fat to muscle rate 0.35-0.40). On the basis of the above findings, the applied CT scanning method was proven to be suitable to follow in vivo the maturation process of male eels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-7345.2004.tb01077.x
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  • 3
    Electronic Resource
    Electronic Resource
    Measurement of total body composition changes of common carp by computer tomography (2003)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 34 (2003), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The crude fat and protein content of the total body was estimated by X-ray computer tomography (CT) and determined by chemical analyses during a feeding experiment with sexually matured common carp. Between 21 and 35 serial scans were taken of altogether 41 fish and samples from the homogenized body were prepared for chemical analyses. Experimental fish with an average body weight of 1453 g originated from a commercial stock of mirror carp. Two feeding regimes (carp feed and carp feed+ad libitum maize) were applied for 57 days and followed by a fasting period of 27 days. Both feeding regimes significantly increased the crude fat content of the whole body that did not decrease during fasting in spite of high water temperature (22°C). No significant changes were observed in crude protein content. The variables used for producing the prediction equations were taken from the density values of the Hounsfield scale, on a range between −90 and +160, by summing the frequencies within each interval of 10 values. Whole body fat content could be estimated with R2=0.89−0.91 accuracy with the principal component analysis using data of all (seven) body regions and only dorsal fin region respectively. Adequate linear regression model could not be calculated by the same procedure for crude protein. Three-dimensional ‘volumetric’ estimation of fat tissue was also carried out on the basis of fat index showing high correlation with measured fat content. The changes of body composition of individual fish can be followed by sequential CT scanning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.2003.00900.x
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