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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 113 (1997), S. 431-442 
    ISSN: 1432-1106
    Keywords: Key words Corticocortical relationships ; Area 17 ; Area 18 ; Spatial frequency ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this investigation was to understand the functions of long horizontal connections projecting from area 17 to area 18 in cats. The animals were anesthetized and prepared for recording single-cell responses to sine-wave gratings in area 18. Neuronal activity was analyzed under three conditions: prior to, during, and after inactivation of a circumscribed region of area 17. The latter was depressed with micro-injections of GABA. Cells in both areas were in close retinotopic correspondence. Cells were classified as simple and complex types. Globally, simple cells were less affected than complex units, and those which were affected shifted their optimal spatial frequency to higher values. Complex neurons were more often influenced by the interruption of area 17 input. Namely, the peaks of the tuning curves were displaced on the x-axis to a new optimal spatial frequency. This effect was obtained by a dual change: a decline in the discharge strength to the optimal spatial frequency and an enhancement to nonoptimal spatial frequency. Contrast sensitivity function disclosed similar shifts of optimal spatial frequencies. Likewise bandwith, spatial resolution, high cutoff, and low cutoff were modified to a greater extent in complex cells. It appears that there is no relationship between areas 17/18 orientation difference and the modifications observed in tuning curves to spatial frequencies. The results suggest that neurons of area 18 may carry multiple-frequency channels and that area 17 facilitates the emergence of one particular spatial frequency.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 50 (1983), S. 392-396 
    ISSN: 1432-1106
    Keywords: Corpus callosum ; Visual cortex ; Optic tract section ; Binocular cells ; Cats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cells in area 17 of the cortex are generally activated either directly through a retino-thalamic pathway or indirectly via a contralateral hemispherecallosal pathway. The aim of the present experiment was to evaluate the effects of eliminating this second pathway on the binocular activation of cells in the primary visual cortex. The optic tract was sectioned on one side in 18 cats and unit activity was recorded in the contralateral hemisphere. This hemisphere should receive normal thalamo-cortical inputs but no visual callosal input. These animals were compared to 21 normal cats. Extracellular electrophysiological recordings were carried out in the conventional way using tungsten microelectrodes and N2O anaesthesia. Results indicated that the proportion of binocular cells found in the cortex of tract sectioned animals was lower than that found in normal animals. However, this decrease in binocularity could be essentially attributed to cells having receptive fields situated to within 4 ° of the vertical meridian of the visual field. These results are interpreted as being congruent with the demonstrated anatomo-physiological projections of the callosal system.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 40 (1980), S. 221-228 
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Superior colliculus ; Rabbits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anesthetized and paralyzed rabbits, unit responses of lateral geniculate nucleus (LGN) cells to focal electrical stimulation of the superior colliculus were studied. Geniculate responses to collicular stimulation (SCS) were compared with responses to optic nerve shock (ONS). A weak correlation coefficient suggested that collicular stimulation did not fire geniculate cells through collateral activation. Further differentiation between collicular and retinofugal inputs to LGN was made possible by repetitive stimulation. Geniculate cells which responded to collicular stimulation were relay cells as they were antidromically invaded from the visual cortex. This ruled out recordings from the ventral geniculate, since this area does not project to the visual cortex. A direct colliculo-geniculate pathway was revealed by antidromic activation of collicular cells by stimulation of the dorsal LGN. Finally, triggering flashes by collicular firing resulted in a marked modification of the geniculate test response. The results suggest that the superior colliculus sends fibers to the LGN and is capable of modulating the retino-cortical neuronal message at the level of the LGN.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 29 (1977), S. 527-530 
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Cortical depression ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Corticofugal influence upon lateral geniculate units was eveluated by inactivating the visual cortex with a topical application of 3 M KCL in rabbits. The results revealed a decrease of spontaneous firing in slow P cells following cortical depression suggesting a tonic corticofugal influence. The most consistently observed alteration was an enhancement of the ON response with a decrease of the response to the opposite stimulus (OFF); and vice versa: the short latency excitation being augmented. It is suggested that the visual cortex exerts a powerful influence on intra-geniculate inhibitory processes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 53 (1984), S. 223-232 
    ISSN: 1432-1106
    Keywords: Cortico-geniculate influence ; Lateral geniculate nucleus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unitary discharges of the lateral geniculate nucleus (LGN) were analyzed in anesthetized and paralyzed rats after inactivation of visual cortical areas (VC) by cryoblockade or by depositing a cotton wick soaked in KCl (3 M). The receptive fields were mapped prior to and following the interruption of the cortico-geniculate feedback. The responsiveness of the VC was controlled by monitoring evoked potentials and the EEG. In most off-center and about half on-center cells the surround excitatory responses were markedly reduced and even totally abolished. In contrast, the center excitation remained unchanged or increased suggesting a parallel decline of the inhibitory surround. This differential influence of cortical blockade on on- or off-responses failed to appear in on-off cells whose receptive field was nonconcentrically organized. It is proposed that the VC exerts a complex influence upon geniculate physiology while the spatial center-surround relationships are under the control of the VC. The results of this investigation are comparable to those obtained in rabbits and cats.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Superior colliculus ; Rabbits ; Interactions between two stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study analyzes the interactions between two discrete stimuli located in the visual field of the rabbit at the lateral geniculate level. Single unit recordings were carried out simultaneously from the superior colliculus (SC) and lateral geniculate nucleus (LGN) in anesthetized and paralyzed rabbits. A first conditioning stimulus (most often a moving target) was positioned in the receptive field of the collicular cell to ensure activation of the retino-collicular path. A second test stimulus was introduced into the receptive field of the LGN cell. The presentation of this latter stimulus was timed so as to fire the geniculate cell at various delays after the collicular neuron had responded to its own stimulus. The spontaneous firing of each cell was unaffected by the stimulus appropriate to the complementary unit. The conditioning collicular stimulus produced increases or decreases in geniculate responses. This modulation may eventually reduce the direction specificity of a geniculate unit. The fluctuations of the geniculate responses peaked 200 to 300 ms after collicular cells had responded. In a separate series of experiments the influence of the conditioning stimulus on geniculate responses was abolished when the SC was locally inactivated. These results suggest that the well documented colliculo-geniculate system mediates the interactions of several stimuli in the visual field. The outcome of this processing results in a modulation of geniculate responses.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 6 (1994), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The goal of this study was to examine the role of horizontal connections in rabbit striate neurons. Anaesthetized rabbits were prepared in the usual fashion for single-cell recordings in area 17 of the visual cortex. We compared responses evoked by moving and stationary stimuli prior to, during and after recovery from lateral microinjection of either lidocaine (n= 61), γ-aminobutyric acid (GABA, n = 18) or bicuculline (n= 8) 2 mm from the recording site. This procedure allows evaluation of the contribution of neighbouring neurons in visual responses. Results showed that striate neurons are dependent on the adjacent cells1 excitability. Modification of responses to stationary targets suggests that lateral interactions play a role in the generation of discharges to fixed stimuli. Lateral inactivation preferentially influenced non-directional over direction-selective units. This influence usually resulted in the non-directional neuron becoming directional by attenuation of the visually driven response in one direction. Simple and complex cells tended to be influenced differently by lateral inactivation. Simple cells became less responsive, whereas complex cells became more responsive. This dichotomy among cellular types suggests that simple cells receive mainly excitatory horizontal influences, while complex cells are contacted mostly by lateral inhibitory inputs.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 89 (1992), S. 531-539 
    ISSN: 1432-1106
    Keywords: Visual cortex ; Response to motion ; Direction index (DI) ; Cortico-cortical relationships ; Rabbits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The described investigations study the influence of additional targets located well outside the classical receptive field on responses to motion of cortical cells in rabbits. Animals are anesthetized and prepared for acute single cells recordings in a conventional manner. The interactions between remote targets and central stimuli are abolished with microinjections of lidocaine hydrochloride or GABA at the site excited by remote stimuli. Results show that responses to motion of cortical cells are particularly sensitive to these manipulations. Although supplementary targets fail to influence spontaneous activity of all cells, they do influence responses to motion. Overall, the directionality indices (DI) declined. (53 to 45.) This decline may express itself either by a decrease of responses in the preferred direction or an enhancement of responses in the non-preferred direction or both. By contrast, responses to stationary stimuli are unaffected by additional targets in the visual field. Globally, cells whose directionality index was superior to 50% were significantly more affected then cells whose DI was less than 50%. This result suggests that similarly to cats, the directionality of cells in the striate cortex rests on a very fragile convergence of excitatory and inhibitory influences.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 33 (1977), S. 232-234 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In rabbits, simultaneous recordings of unitary activity of lateral geniculate nucleus and superior colliculus revealed that some neurons of these structures presented fluctuations in their firing pattern which are opposite in phase.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 80 (1990), S. 387-396 
    ISSN: 1432-1106
    Keywords: Lateral posterior nucleus ; Pulvinar ; Superior colliculus ; Tecto-LP pathway ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lateral posterior-pulvinar (LP-P) complex of mammals receives a major input from the superior colliculus (SC). We have studied the response properties of LP cells and investigated the effects of reversible inactivation of the colliculus on the visual responses of LP units in anesthetized and paralyzed rabbits. Cells in LP had large receptive fields responsive to either stationary or moving stimuli. One third of the motion-sensitive cells were direction selective. The size of the receptive fields increased with eccentricity and there was a retinotopic organization along the dorso-ventral axis. Comparison of the LP and superior colliculus properties revealed substantial differences in visual response characteristics of these two structures such as the size of the receptive fields and the number of direction-selective cells. Electrical stimulation of the LP evoked antidromic action potentials in tectal cells that were motion sensitive. We found a dorsoventral gradient in the projections of collicular cells. Units located more dorsally in the colliculus sent their axons to LP while cells lying more ventrally sent axons toward the region lying posterior to LP. A micropipette filled with lidocaine hydrochloride was lowered into the superficial layers of the superior colliculus in order to reversibly inactivate a small population of collicular cells. Rendering the superior colliculus inactive produced a sharp attenuation of visual responses in the majority of LP cells. Some neurons ceased all stimulus-driven activity after collicular blockade while a few cells exhibited increased excitability following collicular inactivation. These experiments also indicate that the tecto-LP path is topographically organized. An injection in the colliculus failed to influence the thalamic response when it was not in retinotopic register with the LP cells being recorded. Our results demonstrate that the superior colliculus input to LP is mainly excitatory in nature.
    Type of Medium: Electronic Resource
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