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  • 1
    Electronic Resource
    Electronic Resource
    The cost associated with intraperitoneal versus subcutaneous administration of erythropoietin (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 377-377 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956759
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 850-854 
    Details
    ISSN: 1432-1076
    Keywords: CAPD ; Children Erythropoietin ; Pharmacokinetics Intraperitoneal administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In children treated by continuous ambulatory peritoneal dialysis (CAPD) renal anaemia is preferably treated by intraperitoneal administration of erythropoietin, since subcutaneous administration is painful and frightening for the child. Pharmacokinetics of erythropoietin were studied in three groups of children treated by CAPD. In group subcutaneous (SC) (n=5) erythropoietin was administered subcutaneously, whereas in group intraperitoneal 1 (IP1) (n=8) and intraperitoneal 2 (IP2) (n=8) erythropoietin was given intraperitoneally during a 12-h dwell. Group IP1 received erythropoietin in 20 ml/kg of dialysis fluid, while in group IP2 the hormone was added to only 50 ml of dialysate, irrespective of body weight. The median area under the curve (AUC) was 4064 mU·h/ml (range 2647–24357) in group SC, 1698 (570–5514) in group IP1 and 3577 (1225–6555) in group IP2. In comparison to group SC the AUC was significantly lower in group IP1 (Wilcoxon;P=0.02). The difference between group SC and group IP2 was not statistically significant. In children on CAPD the resorption of erythropoietin after intraperitoneal administration, measured as AUC, is similar to subcutaneous administration, when erythropoietin is administered in 50 ml of dialysate. The dose needed to treat renal anaemia with erythropoietin administered intraperitoneally this way will have to be established in a therapeutic study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972896
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reduction of potassium in drinks by pre-treatment with calcium polystyrene sulphonate (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 263-264 
    Details
    ISSN: 1432-1076
    Keywords: Potassium restriction ; Calcium polystyrene sulphonate ; Chronic renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dietary potassium intake in patients with chronic renal failure is generally reduced by oral administration of potassium-binding resins. These drugs may cause disturbances of bowel function and have an unpleasant taste. Pre-treatment of drinks with these resins and their subsequent removal may prevent these inconveniences. In four formulas (whole milk, humanised infant formula, apple juice, and orange juice) we were able to lower the potassium content by 50% with calcium polystyrene sulphonate. No important increase of sodium content was observed, as was reported with the use of sodium polystyrene sulphonate. There was a, potentially beneficial, increase of the calcium concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956159
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for intact V1-vasopressin receptors in congenital nephrogenic diabetes insipidus (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 381-383 
    Details
    ISSN: 1432-1076
    Keywords: Nephrogenic diabetes insipidus ; Platelets ; Vasopressin receptor-Kd-Bmax
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The binding of tritium-labelled arginine vasopressin to human platelet vasopressin receptors was investigated in patients with congenital nephrogenic diabetes insipidus. Binding characteristics, that is receptor affinity and the maximum number of binding sites, were not significantly different from those found in normal control individuals. The findings confirm the concept of intact V1 receptors in congenital nephrogenic diabetes insipidus. The defect in nephrogenic diabetes insipidus apparently only affects the cyclic adenosine monophosphate dependent V2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113263
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  • 5
    Electronic Resource
    Electronic Resource
    Infectious and surgical complications of childhood continuous ambulatory peritoneal dialysis (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 377-380 
    Details
    ISSN: 1432-1076
    Keywords: Continuous ambulatory peritoneal dialysis ; Surgical complications ; Peritonitis ; Hernias ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 10-year retrospective study was performed with respect to the incidence of infectious and surgical complications in a young paediatric continuous ambulatory peritoneal dialysis population of 43 children (mean age 4.5 years [range 2.5 months-15.8 years]). The incidence of infectious complications such as peritonitis and catheter-related infections correlated well with the results of other studies. A relatively high incidence of hernias (53%) was seen in our population, probably caused by the lower mean age of the children. Obstructions were caused by omental wrapping, peritonitis, or operative procedures and did not correlate with the period of cathter function. Early leakage occurred within 5 days after catheter implantation. Later leakages were preceeded by another complication, such as infection or obstruction. In early leakage, in contrast to later leakage, the catheter could be maintained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113262
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 850-854 
    Details
    ISSN: 1432-1076
    Keywords: Key words     CAPD ; Children ; Erythropoietin ; Pharmacokinetics ; Intraperitoneal administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      In children treated by continuous ambulatory peritoneal dialysis (CAPD) renal anaemia is preferably treated by intraperitoneal administration of erythropoietin, since subcutaneous administration is painful and frightening for the child. Pharmacokinetics of erythropoietin were studied in three groups of children treated by CAPD. In group subcutaneous (SC) (n = 5) erythropoietin was administered subcutaneously, whereas in group intraperitoneal 1 (IP1) (n = 8) and intraperitoneal 2 (IP2) (n = 8) erythropoietin was given intraperitoneally during a 12-h dwell. Group IP1 received erythropoietin in 20 ml/kg of dialysis fluid, while in group IP2 the hormone was added to only 50 ml of dialysate, irrespective of body weight. The median area under the curve (AUC) was 4064 mU ·h/ ml (range 2647–24357) in group SC, 1698 (570–5514) in group IP1 and 3577 (1225–6555) in group IP2. In comparison to group SC the AUC was significantly lower in group IP1 (Wilcoxon; P = 0.02). The difference between group SC and group IP2 was not statistically significant. Conclusion     In children on CAPD the resorption of erythropoietin after intraperitoneal administration, measured as AUC, is similar to subcutaneous administration, when erythropoietin is administered in 50 ml of dialysate. The dose needed to treat renal anaemia with erythropoietin administered intraperitoneally this way will have to be established in a therapeutic study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050229
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Intraperitoneal administration of recombinant human erythropoietin in children on continuous ambulatory peritoneal dialysis (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 540-542 
    Details
    ISSN: 1432-1076
    Keywords: CAPD ; Children ; Erythropoietin ; Intraperitoneal administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 16 children treated by continuous ambulatory peritoneal dialysis (CAPD) recombinant human erythropoietin was administered intraperitoneally for the treatment of renal anaemia. The mean treatment period was 8.3 months. Mean haemoglobin values increased from 4.9 mmol/l at start of therapy to 6.2 after 6 months. While 11 out of 16 children needed a total of 22 transfusions during the 6 months prior to therapy, no transfusions were needed after initiation of therapy. Patients started with a dose of 300 units/kg per week. After 6 months of therapy, the mean dose was 370 and after 12 months 279 units/kg per week. No major side-effects were observed. The incidence of peritonitis was not increased. We conclude that intraperitoneal administration of erythropoietin is effective in the treatment of renal anaemia in children treated by CAPD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957764
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  • 8
    Electronic Resource
    Electronic Resource
    A variant of nephrogenic diabetes insipidus: V2 receptor abnormality restricted to the kidney (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 370-373 
    Details
    ISSN: 1432-1076
    Keywords: Nephrogenic diabetes insipidus ; Heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In congenital nephrogenic diabetes insipidus (NDI) blunted responses of plasma factor VIII, von Willebrand factor, and plasminogen activator to the synthetic V2 analogue 1-desamino-8-d-arginine vasopressin (DDAVP) have been reported. In addition, vasodilatory responses to DDAVP appear to be absent in NDI. We describe a boy, who presented shortly after birth with the typical features of NDI, but who showed normal coagulation, fibrinolytic and vasodilatory responses to DDAVP. We conclude that in this patient the defect is confined to the kidney, while in other NDI patients there may be a general V2 receptor abnormality. These findings point to heterogeneity in NDI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955943
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Contribution to scientific research in paediatrics in The Netherlands: evaluation according to subspeciality over a 10-year period (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 870-872 
    Details
    ISSN: 1432-1076
    Keywords: Scientific research ; Paediatrics ; The Netherlands ; Quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The board of the Dutch Paediatric Association requested a survey of the scientific research performed in all academic and non-academic paediatric hospitals, authorized to train medical doctors in paediatrics in the Netherlands. Contributions to the international and the Dutch scientific literature, in the form of regular publications, chapters in books, contributions to proceedings and Ph.D. theses were counted over two 5-year periods, i.e. 1981–1985 and 1986–1990. The quality of publications in the international journals was assessed using the average impact factor of the journals over the 10-year period. The number of publications in the international literature doubled during the observation period 1986–1990 compared to the period 1981–1985. Nevertheless, the quality of the publications remained the same. Metabolism, oncology/ haematology, immunology/infectious diseases and cardiology are the subspecialisations in which scientific research takes place in four or more academic paediatric hospitals. In total, 84 Ph.D. theses were produced in which a paediatrician was either the project leader (mostly a professor in paediatrics) or the investigator-in-charge. Insight into structure and major research efforts of paediatric hospitals in other countries of Europe may lead to exchange of views and, maybe, profitable co-operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957518
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Furosemide versus thiazide in Gordon syndrome (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 621-621 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957921
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    Paper (German National Licenses)
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