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  • 1
    Electronic Resource
    Electronic Resource
    Contrast-enhanced ultrasonography of native and transplanted kidney diseases (1999)
    Springer
    European radiology 9 (1999), S. S394 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014082
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  • 2
    Electronic Resource
    Electronic Resource
    Imaging of obstructive azoospermia (1997)
    Springer
    European radiology 7 (1997), S. 1079-1085 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Obstructive azoospermia ; Scrotal ultrasonography ; TRUS ; Endorectal MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Obstructive azoospermia represents approximately 10 % of cases of male hypofertility. It is classified according to the volume of ejaculate. When the latter is normal a proximal obstruction is suspected. Scrotal sonography can help to detect dilation of the epididymal head when clinical findings are equivocal. Ejaculatory duct obstruction (EDO) is suspected when the volume of ejaculate is low. The use of transrectal ultrasonography (TRUS) plays a major role in the investigation of these patients, and endorectal MRI is a very useful adjunct in selected cases. The most common cause of EDO is congenital bilateral absence of vas deferens, which is now thought to be a genital form of cystic fibrosis in 80 % of cases. Consequently, a definitive diagnosis must be made before any attempt at in vitro fertilization. TRUS accurately visualizes abnormalities of the caudal junction of the vas deferens and seminal vesicles, yielding a definitive diagnosis without scrototomy. Other causes of EDO are congenital cysts compressing the distal part of the ejaculatory ducts and inflammatory distal stenosis. The former are accurately identified by TRUS, but the latter give more or less marked signs of obstruction which are only of value in azoospermic patients with a low-volume ejaculate. More invasive imaging is required to diagnose partial obstruction of the ED. Surgical vasography is still the reference, but puncture of the seminal vesicles under TRUS guidance is an attractive alternative, as it permits aspiration of seminal fluid (to seek motile sperm) and vasography without scrototomy. Lastly, endorectal MRI well assesses the relationships between the proximal prostatic urethra and the posterior wall of the ejaculatory ducts, which need to be precisely known when endoscopic resection of the ejaculatory ducts is planned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050258
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  • 3
    Electronic Resource
    Electronic Resource
    Varicocele: strategies in diagnosis and treatment (1999)
    Springer
    European radiology 9 (1999), S. 536-545 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Varicocele ; Continuous Doppler ; Pulsed Doppler ; B mode sonography ; Color Doppler sonography ; Spermatic veins ; embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Varicocele can be very easily diagnosed by physical examination and subsequently treated when it is painful or associated with testicular hypotrophy. However, palpability of the spermatic vein and reflux in low grade or even questionable varicoceles can be difficult to assess without imaging modalities. This can be a common problem for all physicians treating hypofertile men to decide whether the varicele needs to be treated or not. However, a gold standard that defines the presence of a subclinical varicocele has not yet been established. The different diagnostic tools based on ultrasonography investigated these past years to define a flow reversal in incontinent spermatic veins are presented in the first part of this review, with emphasis on subclinical varicocele. In the second part, we present our experience, together with a review of the literature concerning embolization of the spermatic veins as an alternative to surgery to treat varicoceles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050706
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  • 4
    Electronic Resource
    Electronic Resource
    Distinct presentations of radiocontrast-induced sialadenitis in renal insufficients and in patients with normal renal function (1994)
    Springer
    European radiology 4 (1994), S. 254-257 
    Details
    ISSN: 1432-1084
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two incide ntal observations of radiocontrast-induced sialadenitis which occurred in a patient with normal renal function and in another patient undergoing chronic haemodialysis. Our first observation consisted of parotid gland, enlargement noted 1 h after contrast injection and which presaged anaphy lactoid shock. In the second cast salivary gland enlargement developed 3 days after administration of iodinated agent. A review of the literature based on 27 published observations. In dicates that two different presentations of iodide-induced sialadenitis canbe recognisedaccording totheirpathogenesis. In patients with normally functioning kidneys, the occurrence of sialadenitis after a shortdelay(5 min to 24 h) evokes an anaphylactoidmechanism. Conversely, in patients with impaired renal function, the delayed onset (1–5 days) of this adverse reaction suggest a toxic effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606456
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  • 5
    Electronic Resource
    Electronic Resource
    Vascular rupture complicating transluminal angioplasty applied on a failed dialysis vascular access in a patient under chronic steroid therapy (1997)
    Springer
    European radiology 7 (1997), S. 313-315 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Veins ; Transluminal angioplasty ; Dialysis ; Shunt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report a case of venous rupture complicating percutaneous transluminal angioplasty (PTA) applied on a failed dialysis vascular access (VA) in a patient on chronic steroid therapy. This complication resulted in a rapidly growing hematoma which was successfully controlled by a prolonged reinflation of the balloon catheter at the angioplasty site. The absence of oversizing of the balloon catheter and the low inflation pressure at which the perforation occurred suggest a vessel fragility which was probably induced by a long-standing steroid therapy. In dialysis patients in whom steroid therapy does not represent an infrequent therapeutic modality, this potential risk of vascular rupture should be carefully weighted while treating VA stenoses with the use of PTA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050156
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular mimicry of erythropoietin by the spleen focus-forming virus gp55 glycoprotein: the first stage of Friend virus-induced erythroleukemia
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Reviews on Cancer 1114 (1992), S. 31-41 
    Details
    ISSN: 0304-419X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0304-419X(92)90004-I
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  • 7
    Electronic Resource
    Electronic Resource
    Immunogenicity of HILDA/LIF either in a Soluble or in a Membrane Anchored Form expressed In Vivo by Recombinant Vaccinia Viruses (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 38 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Insertion of various cDN As in the genome of the vaccinia virus (VV) enables the in vivo and in vitro study of the functional role and/or the immunogenicity of the virally encoded recombinant proteins. We have prepared a recombinant VV expressing the cDNA of the human cytokine HILDA/LTF (human interleukin for DA cells/leukaemia inhibitory factor), and used this virus to immunize mice against this protein, which is very homologous to its murine counterpart (∼80% homology). We also constructed and expressed by the same system a chimeric gene encoding the HILDA/LIF protein fused to the 37 COOH-terminal amino-acids of the human decay accelerating factor (DAF). This sequence proved to be sufficient for the targeting of the fusion protein to the cell membrane, where it is linked to the phosphatidylinositols. Both recombinant VVs induced cytokine-specific antibodies in mice as analysed with an FLISA where the recombinant HILDA/LIF was plastic-coated and a cytofluorometric assay where the LIF-DAF molecule was present at the cell surface of stably transfected PS15. In the latter case HILDA/LIF remained biologically active suggesting that it was expressed in its native form. The LIF-DAF fusion protein was found to exhibit a better capacity to elicit an antibody response against the native form of the cytokine as detected in cytofluorometric assays. Whatever the recombinant virus used to immunize the mice, the MoAbs obtained were positive either in the ELISA or in the cytofluorometric assays but one, which suggested that the plastic coating induced a conformationa1 change of HILDA/LIF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb01728.x
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  • 8
    Electronic Resource
    Electronic Resource
    0.5 T MRI of small renal masses: value of T2-weighted and Gd-DOTA-enhanced images (1993)
    Springer
    European radiology 3 (1993), S. 447-452 
    Details
    ISSN: 1432-1084
    Keywords: Gadolinium ; Kidney, benign tumours ; Kidney, cysts ; Kidney, MRI studies ; Kidney, neoplasms ; MRI, contrast enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the value of T2-weighted and Gd-DOTA-enhanced T1-weighted images for the detection and characterisation of 33 small renal masses (14 clear cell carcinomas, 6 angiomyolipomas, 3 angiomyomas, 4 adenomas, 3 papillary carcinomas, 3 oncocytomas, 1 haemorrhagic cyst). Dynamic enhanced MRI was performed to study the tumoral vascular supply (19 cases). MRI depicted all the masses more than 1 cm in diameter, but missed all the lesions less than 1 cm (4 false-negative). The results of T2-weighted images and Gd-DOTA-enhanced images were similar as regards detection; however, Gd-DOTA-enhanced images depicted more clearly the tumours smaller than 2 cm (11 cases). MRI enabled the characterisation of only 3 masses (2 angiomyolipomas, 1 haemorrhagic cyst). New MRI features are described for oncocytomas (low signal intensity on T1-weighted images, high signal intensity on T2-weighted images, early and marked enhancement on dynamic enhanced MRI). Dynamic enhanced MRI did not contribute to the differentiation of benign from malignant tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221422
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  • 9
    Electronic Resource
    Electronic Resource
    Sequential production of leukaemia inhibitory factor by blood cell culture in patients with ARDS (1998)
    Springer
    Intensive care medicine 24 (1998), S. 366-368 
    Details
    ISSN: 1432-1238
    Keywords: Key words Acute respiratory distress syndrome ; Leukaemia inhibitory factor ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Leukaemia inhibitory factor (LIF) is a polyfunctional cytokine integrated in cytokine networks and its concentration has been shown to be elevated in bronchoalveolar lavage fluid of patients with the acute respiratory distress syndrome (ARDS). The aim of our study was to evaluate the production of LIF by culturing blood cells from patients with ARDS. Patients: 8 patients with ARDS, 8 patients with pneumonia and 5 healthy subjects. Measurements and results: The blood samples were taken on day 1 after onset of ARDS. LIF was measured, in the cell-free supernatant, with an enzyme-linked immunosorbent assay after 24 h, 48 h and 72 h of blood cell culture. LIF was detectable in some patients in the ARDS group: at i) at 24 h and 48 h: in 2 patients ii) at 72 h in 4/5 patients (140 ± 231 pg/ml). Only in the 4 patients in whom LIF was measured at 72 h was ARDS associated with the multiple organ dysfunction syndrome. Furthermore, among the 5 patients with ARDS who subsequently died, 4 had a detectable LIF. Conclusions: We have observed that LIF was produced only in ARDS, but not in all patients. The production of LIF seems to be a good indicator of the severity of ARDS. These preliminary results must be confirmed by a larger study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050582
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  • 10
    Electronic Resource
    Electronic Resource
    Immune repertoire of graft-invading T cells (1990)
    Springer
    Transplant international 3 (1990), S. 176-180 
    Details
    ISSN: 1432-2277
    Keywords: T-cell repertoire ; Organ transplantation, T-cell repertoire ; Rejection, T-cell repertoire
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The immune repertoire of T lymphocytes invading human allografts is of fundamental importance both at the operational level, in order to achieve relevant matching, and at the functional level, since the unique capacity of T and B cells to specifically recognize allogeneic components restricts the origin of the signals leading to rejection by these cells. In this paper, the authors review their own work, as well as other contributions in this domain, with special reference to the frequency and function of donor-committed cells among the infiltrate and the relationship between T-cell receptor gene rearrangements and repertoire.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355467
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