ISSN:
1434-0879
Keywords:
Kidney transplantatioon
;
Rat
;
PUVA therapy
;
Ultraviolet irradiation
;
Azathioprine
;
Prednisolone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pretreatment of the kidney donor with 8-methoxy-psoralen (8-MOP) and direct longwave ultraviolet (UVA) irradiation of the kidney graft (PUVA therapy) significantly prolonged survival in allogeneic recipients. 40% of the recipients survived more than 100 days with normal transplant function. The addition of standard clinical immunosuppressive agents azathioprine and prednisolone (both at dosages of 15 mg/kg body weight/day for 21 days) to the PUVA therapy further improved graft survival rate, with a recipient survival rate of 62.5%. The two drugs alone were less effective in prolonging graft survival rate (28.5%). A synergistic effect of PUVA therapy and standard immunosuppressive treatment with azathioprine and prednisolone was demonstrated. This suggested a possible clinical application of this type of immunosuppression and immunoregulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00255528
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