Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Platelet survival determined with51Cr Versus111In (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 84-89 
    Details
    ISSN: 1432-1440
    Keywords: Thrombocytopenia ; Platelet survival ; 51Cr ; 111In
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Optimal labelling conditions of human platelets with111In-oxine were determined in vitro. Based on this optimized technique, platelet mean life span (MLS) and platelet sequestration site were comparatively evaluated in 79 patients with two labels,51Cr (n=26) and111In (n=53). Patients were subgrouped according to clinical criteria as autoimmune thrombocytopenic purpura (AITP) (group 1;n=49), hypersplenism (2;n=12), impaired thrombopoiesis (3;n=3), unclassified thrombocytopenia (4;n=6), and nonthrombocytopenic patients (5;n=9). In patients with AITP and hypersplenism the mean values for the MLS determined either with51Cr or with111In were lowered but the difference was not statistically significant, neither for group 1 (18.6 h vs 17.3 h;P〉0.2) nor for group 2 (94.7 vs 122.3 h;P〉0.2). The correlation between MLS and platelet counts in patients with AITP was significant for both labels (P〈0.001). The 15 min recovery tended to be higher with111In in all groups, but the difference was significant (P〈0.05) only for group 1. The sequestration sites were similar with both labels. We conclude that, contrary to previous reports, platelet survival studies yield similar results with both the51Cr and111In methods. Due to its distinct advantages111In is the label of choice for investigation of platelet kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733073
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    HLA-B27, antinuclear antibodies and drug-induced agranulocytosis (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 1189-1191 
    Details
    ISSN: 1432-1440
    Keywords: HLA-B27 ; Antinukleäre Antikörper ; Agranulozytose ; Rheumatoide Arthritis ; HLA-B27 ; Antinuclear Antibodies ; Agranulocytosis ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Eight female patients with drug-induced agranulocytosis (five patients with definite seropositive rheumatoid arthritis (RA), three patients with upper respiratory infections) were studied for the presence of HLA-B27 and antinuclear antibodies (ANA). Five of eight patients were found to be HLA-B27 positive and all RA patients had ANA in their serum. The frequency of HLA-B27 and ANA was found to be significantly different from control groups. It is concluded that the occurrence of HLA-B27 in female patients with seropositive RA (especially in those with ANA) and of HLA-B27 alone in other individuals could reflect an increased risk for drug-induced agranulocytosis.
    Notes: Zusammenfassung Acht weibliche Patienten mit medikamentös ausgelöster Agranulozytose (fünf Patienten mit definitiver seropositiver rheumatoider Arthritis (RA), drei Patienten mit Infekten der oberen Luftwege) wurden auf das Vorliegen des HLA-Antigens B27 und von antinukleären Antikörpern (ANA) untersucht. Fünf von acht Patienten waren B27-positiv; alle Patienten mit RA hatten ANA in ihrem Serum. Die Frequenz von HLA-B27 und ANA war signifikant gegenüber Kontrollgruppen erhöht. Wir vermuten, daß das Vorkommen von HLA-B27 bei Frauen mit seropositiver RA (besonders bei jenen mit ANA) und von HLA-B27 allein bei anderen Personen Ausdruck eines erhöhten Risikos für eine medikamentös ausgelöste Agranulozytose sein könnte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476864
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Posttransfusion purpura (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 1198-1203 
    Details
    ISSN: 1432-1440
    Keywords: Posttransfusion purpura ; Thrombocytopenia ; Blood transfusion ; Platelet antibodies ; HLA antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen cases of posttransfusion purpura (PTP) which were diagnosed in Germany and Austria from 1977–1985 are described. All patients were women with a mean age of 58.6 years (range, 36–77 years). All but one had been pregnant and received blood transfusions 2 to 12 days prior to the onset of PTP. The thrombocytopenic purpura was always severe with a nadir of platelet counts below 10×109/l and lasted between 3 and 60 days. All patients recovered from PTP. Optimal therapy consisted of administration of high-dose IgG. Twelve of the 13 patients had developed platelet-specific Zwa antibodies (eight of them together with HLA antibodies), in one Zwa positive individual only HLA antibodies were detectable. Five of six HLA-DR typed patients carried DR3 which is considered an immunogenetic risk factor in PTP. Clinical awareness of this rare, but serious iatrogenic transfusion complication is prerequisite for prompt diagnosis and improved therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728461
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Kälteagglutininkrankheit (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 1041-1042 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733454
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Treatment of childhood idiopathic thrombocytopenic purpura with Rhesus antibodies (anti-D) (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 166-169 
    Details
    ISSN: 1432-1076
    Keywords: Idiopathic thrombocytopenic purpura ; Immunoglobulin Anti-D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently reported that a rise of platelet numbers in ITP can be induced by blockade of the RES with antibody-coated red blood cells. We now present a collaborative study in which 15 Rhesus-positive children with ITP (nine boys and six girls aged 1–15 years) were treated with low-dose anti-D. Ten patients had chronic ITP (duration 6–47 months), five had acute ITP. Doses of 28–50 μg anti-D/kg bodyweight per course were given intravenously. In all patients clinical signs of bleeding ceased and platelet counts were elevated. An excellent, good or fair response with platelet increments of 〉100, 50–100, or 20–50×109/l, respectively, was observed in 19, 7, and 12 out of 45 courses in chronic ITP, and in 4, 1, and 2 out of 8 courses in acute ITP. The platelet increase (〉40×109/l) persisted for 10 to over 360 days in chronic ITP. There were no untoward side reactions. Haemoglobin values remained stable in all patients but laboratory signs of mild, compensated haemolysis ensued. The direct antiglobulin test became positive in all cases due to anti-D IgG. Previous therapy of patients with chronic ITP included high-dose immunoglobulins and prednisone. These regimens were both effective but remissions were short. We conclude that anti-D therapy is an effective and safe form of treatment in childhood ITP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446055
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    May-Hegglin anomaly: A rare cause of thrombocytopenia (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 668-671 
    Details
    ISSN: 1432-1076
    Keywords: Thrombocytopenia ; Giant platelets ; Leucocytes ; May-Hegglin anomaly ; Hereditary thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A family with four and an unrelated family with three individuals affected by the May-Hegglin anomaly are described. Platelet counts were markedly reduced and were correctly determined only in the counting chamber. Bleeding time and platelet aggregation were always normal, but platelet nucleotide concentrations (ATP and ADP) were elevated. The platelet glyco-protein complexes Ib/IX, IIb/IIIa and Ia/IIa were quantitatively normal. Platelet-associated IgG was slightly elevated, although thrombocytopenia was presumably not caused by an immunological mechanism. Morphological investigations showed giant platelets and spindle-shaped inclusion bodies in the granulocytes, while their function (phagocytic capacity, radical production) was normal. To exclude hereditary types of thrombocytopenia, morphological and family investigations are required to avoid misdiagnosis with far-reaching diagnostic and therapeutic consequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957570
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 413-415 
    Details
    ISSN: 1432-1440
    Keywords: Ibuprofen thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute thrombocytopenic purpura temporally related to the oral administration of ibuprofen developed in a patient with ankylosing spondylitis. Clinical manifestations, with sudden onset occurring within t2 h of drug ingestion and rapid increase of platelet counts following discontinuation of the drug, were characteristic of an antibody-mediated immune pathomechanism. Immunological studies demonstrated IgM and IgG antibodies in the patient's serum that were capable of binding to allogenic platelets in the presence of a metabolite preparation. This finding suggested that an ibuprofen metabolite, rather then the drug itself, was the antigenic agent responsible for the immune reaction. Despite its widespread therapeutic use, ibuprofen has not been described previously as causing immune-mediated thrombocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186632
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Significance of complement activation in autoimmune haemolytic anaemia of “Warm type” (1977)
    Springer
    Annals of hematology 35 (1977), S. 447-455 
    Details
    ISSN: 1432-0584
    Keywords: Autoimmune haemolytic anaemia ; Complement fixation ; Serum levels of C3 and C4 ; AutoimmunhÄmolytische AnÄmie ; Komplementbeladung ; C3 und C4 Serumkonzentrationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 79 Patienten mit autoimmunhÄmolytischer AnÄmie vom WÄrmetyp (AIHA) und 7 Patienten mit positivem direkten Antiglobulintest ohne HÄmolyse wurden untersucht, um mögliche ZusammenhÄnge zwischen den Serumkonzentrationen von C3 und C4 und der Komplementbeladung der Erythrozyten zu erkennen. 23 der 79 Patienten mit AIHA wurden mehrfach wÄhrend des klinischen Verlaufs kontrolliert. Die verschiedenen klinischen Formen zeigten keine signifikanten Unterschiede der Serumkomplementwerte. Dagegen wiesen die FÄlle mit Komplementbeladung der Erythrozyten signifikant hÄufiger erniedrigte C3 und C4 Konzentrationen im Serum auf als solche mit alleiniger Immunglobulinlagerung. Die VerÄnderungen von C4 waren ausgeprÄgter als von C3, die Mittelwerte von C4 lagen signifikant niedriger in der Gruppe mit Komplementbindung. Bei gleichzeitiger Nachweisbarkeit von inkompletten WÄrmehÄmolysinen waren die Serumspiegel von C4 wesentlich niedriger als bei FÄllen ohne WÄrmehÄmolysine. WÄhrend des klinischen Verlaufs zeigten die C3 und C4 Konzentrationen eine enge Korrelation zur StÄrke der HÄmolyse.
    Notes: Summary To study possible relationships between serum C3 and C4 levels and fixation of complement components (C) on red cells, 79 patients with autoimmune haemolytic anaemia of warm type (AIHA) and 7 patients of various diseases with positive direct antiglobulintest (DAT) but without haemolysis were investigated. 23 out of 79 patients with AIHA were analyzed repeatedly during the course of the disease. There were no significant differences of C levels between the various clinical types. However, the number of patients with reduced levels of C3 and C4 was significantly higher among cases with C fixation on the red cells than among those with fixation of immunoglobulins alone. Changes were more pronounced for C4 than C3 and mean values of serum C4 were significantly lower in the group with C fixation. If incomplete warm haemolysins were demonstrable, C4 levels were lower than in cases without warm haemolysins. During the clinical course, C3 and C4 concentrations showed a close correlation to the severity of haemolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00996691
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Stimulation of lymphocytes by platelet-antibody-complexes and their role in the pathogenesis of idiopathic thrombocytopenia (1979)
    Springer
    Annals of hematology 39 (1979), S. 53-60 
    Details
    ISSN: 1432-0584
    Keywords: Thrombozyten ; Allo- und Autoantikörper ; Lymphozytenproliferation ; ITP ; Platelets ; Allo- and autoantibodies ; Lymphocyte proliferation ; ITP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of washed human platelets, platelet lysates, and platelet antibody complexes on14C-thymidine incorporation by human lymphocytes was studied. For sensitization of platelets, HLA-specific alloantibodies as well as platelet autoantibodies were used. Lymphocytes for in vitro cultures were collected from unsensitized individuals, healthy women with proven fetomaternal immunization against HLA antigens and patients with idiopathic thrombocytopenic purpura (ITP). Unsensitized platelets have a dose-dependent inhibitory effect on the in vitro proliferation of normal lymphocytes induced by mitogens (PHA, ConA, PWM). Platelet antibody complexes (allo- and autoantibodies; allogenic and autologous lymphocyte-platelet combinations) did not stimulate14C-thymidine incorporation. Lymphocytes from ITP patients showed a significantly reduced stimulatory response toward PHA compared to normal persons. These findings are discussed in the light of our present knowledge regarding the role of cellular immune reactions in the pathogenesis of ITP.
    Notes: Zusammenfassung Es wurde der Einfluß von gewaschenen menschlichen Thrombozyten, von lysierten Thrombozyten und von Thrombozyten-Antikörper-Komplexen auf den14C-Thymidineinbau menschlicher Lymphozyten untersucht. Zur Sensibilisierung der Thrombozyten wurden HLA-spezifische Alloantikörper, wie auch thrombozytäre Autoantikörper verwendet. Die Lymphozyten wurden gewonnen von unsensibilisierten Personen, von gesunden Frauen mit nachgewiesener feto-maternaler Sensibilisierung gegen HLA-Antigene und von Patienten mit idiopathischer, thrombozytopenischer Purpura (ITP). Unsensibilisierte Thrombozyten hatten einen dosisabhängigen Hemmeffekt auf die in vitro Proliferation normaler, mitogenstimulierter (PHA, ConA, PWM) Lymphozyten. Thrombozyten-Antikörper-Komplexe (Allo- und Autoantikörper; allogene und autologe Lymphozyten-Thrombozytenkombinationen) stimulierten den14C-Thymidineinbau nicht. Lymphozyten von ITP-Patienten zeigten eine deutlich verminderte Stimulation durch PHA im Vergleich zu Normalpersonen. Diese Ergebnisse werden diskutiert im Hinblick auf den gegenwärtigen Wissensstand zellulärer Immunreaktionen bei der Pathogenese der ITP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008075
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Post-transfusion thrombocytopenic purpura: Immunological and clinical studies in two cases and review of the literature (1980)
    Springer
    Annals of hematology 40 (1980), S. 249-257 
    Details
    ISSN: 1432-0584
    Keywords: Posttransfusionelle Purpura ; Thrombozytenantikörper ; Post-transfusion purpura ; Platelet antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Two patients with post-transfusion thrombocytopenic purpura are described, the first cases recognized in Austria and Germany. Both patients were female, 51 and 60 years of age. The purpura was evoked by blood transfusions with a latent period of 2 and 7 days. The thrombocytopenic episode lasted for 22 and over 60 days. In one case, thrombocytopenia was associated with agranulocytosis due to transient bone marrow failure. Both patients were negative for the platelet-specific antigen PlA1 (= Zwa). Their sera contained PlA1 as well as potent HLA antibodies. Detailed clinical and serological data are presented. The literature with a total of 25 cases so far reported is surveyed.
    Notes: Zusammenfassung Es werden die ersten beiden Patienten mit posttransfusioneller thrombozytopenischer Purpura beschrieben, die in Österreich und in Deutschland diagnostiziert werden konnten. Beide Patienten waren Frauen im Alter von 51 und 60 Jahren. Die Purpura wurde durch Bluttransfusionen ausgelöst mit einer Latenzzeit von zwei bzw. sieben Tagen. Die thrombozytopenische Phase dauerte 22 bzw. länger als 60 Tage. In einem Fall bestand neben der Thrombozytopenie eine Agranulozytose infolge einer vorübergehenden Knochenmarksinsuffizienz. Beide Patienten waren negativ für das thrombozytenspezifische Antigen PlA1 (= Zwa). Ihr Serum enthielt sowohl PlA1- als auch starke HLA-Antikörper. Die klinischen und serologischen Befunde beider Patienten werden eingehend dargestellt. Eine Literaturübersicht mit bisher 25 beschriebenen Fällen ist angefügt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01080184
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...