ISSN:
1420-908X
Keywords:
IL-1
;
Acute inflammation
;
Oedema
;
Anti-inflammatory
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To evaluate any inhibitory effect of a single dose of human recombinant interleukin-1β (hrIL-1β) on the severity of carrageenan-induced oedema in rats (a commonly used model of acute inflammation), we first injected 0.1 ml of carrageenan (0.2%, 0.5%, or 2%) to induce mild, moderate, or severe inflammation, respectively into the right rear footpad. Then we promptly injected the interleukin (0.02, 0.2, or 2 μg) subcutaneously into the flank. The initial rapid increase in volume of the injected paw (within 2 h of the subplantar injection) was independent of the dose of carrageenan, whereas the increase in volume by 6 to 10 h was dose-dependent, All doses of HrIL-1β inhibited the carrageenan-induced swelling at the 6th hour. In the moderate and severe carrageenan-induced oedemas, the higher dose of HrIL-1β induced a delayed inflammation peaking at 10 h instead at 6 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01986393
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